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Human Enterovirus S...
Human Enterovirus Species B in Ileocecal Crohn's Disease
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- Nyström, Niklas (author)
- Uppsala universitet,Pediatrik,Uppsala University, Sweden
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- Berg, Tove (author)
- Karolinska Institutet,Karolinska Institute, Sweden
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- Lundin, Elin, 1983- (author)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi,Uppsala University, Sweden
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- Skog, Oskar (author)
- Uppsala universitet,Klinisk immunologi,Uppsala University, Sweden
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- Hansson, Inga (author)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi,Uppsala University, Sweden
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- Frisk, Gun (author)
- Uppsala universitet,Klinisk immunologi,Uppsala University, Sweden
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- Juko-Pecirep, Ivana (author)
- Uppsala universitet,Genomik,Uppsala University, Sweden
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- Nilsson, Mats (author)
- Uppsala universitet,Molekylära verktyg,Uppsala University, Sweden
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- Gyllensten, Ulf (author)
- Uppsala universitet,Genomik,Uppsala University, Sweden
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- Finkel, Yigael (author)
- Karolinska Institutet,Karolinska Institute, Sweden
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- Fuxe, Jonas (author)
- Karolinska Institutet,Karolinska Institute, Sweden
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- Wanders, Alkwin (author)
- Uppsala universitet,Molekylär och morfologisk patologi,Uppsala University, Sweden
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(creator_code:org_t)
- Ovid Technologies (Wolters Kluwer Health), 2013
- 2013
- English.
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In: Clinical and Translational Gastroenterology. - : Ovid Technologies (Wolters Kluwer Health). - 2155-384X. ; 4:6
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Abstract
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- OBJECTIVES: Advanced ileocecal Crohn's disease (ICD) is characterized by strictures, inflammation in the enteric nervous system (myenteric plexitis), and a high frequency ofNOD2mutations. Recent findings implicate a role ofNOD2and another CD susceptibility gene,ATG16L1, in the host response against single-stranded RNA (ssRNA) viruses. However, the role of viruses in CD is unknown. We hypothesized that human enterovirus species B (HEV-B), which are ssRNA viruses with dual tropism both for the intestinal epithelium and the nervous system, could play a role in ICD.METHODS:We used immunohistochemistry andin situhybridization to study the general presence of HEV-B and the presence of the two HEV-B subspecies, Coxsackie B virus (CBV) and Echovirus, in ileocecal resections from 9 children with advanced, stricturing ICD and 6 patients with volvulus, and in intestinal biopsies from 15 CD patients at the time of diagnosis.RESULTS:All patients with ICD had disease-associated polymorphisms inNOD2orATG16L1. Positive staining for HEV-B was detected both in the mucosa and in myenteric nerve ganglia in all ICD patients, but in none of the volvulus patients. Expression of the cellular receptor for CBV, CAR, was detected in nerve cell ganglia.CONCLUSIONS:The common presence of HEV-B in the mucosa and enteric nervous system of ICD patients in this small cohort is a novel finding that warrants further investigation to analyze whether HEV-B has a role in disease onset or progress. The presence of CAR in myenteric nerve cell ganglia provides a possible route of entry for CBV into the enteric nervous system.
Subject headings
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine (hsv//eng)
Keyword
- Inflammatory bowel disease
- enterovirus
- biokemi
- Biochemistry
- Patologi
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Nyström, Niklas
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Berg, Tove
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Lundin, Elin, 19 ...
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Skog, Oskar
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Hansson, Inga
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Frisk, Gun
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show more...
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Juko-Pecirep, Iv ...
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Nilsson, Mats
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Gyllensten, Ulf
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Finkel, Yigael
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Fuxe, Jonas
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Wanders, Alkwin
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show less...
- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Biochemistry and ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Gastroenterology ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
- Articles in the publication
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Clinical and Tra ...
- By the university
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Stockholm University
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Umeå University
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Karolinska Institutet
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Uppsala University