Search: onr:"swepub:oai:DiVA.org:su-79795" > The interface of pr...
Fältnamn | Indikatorer | Metadata |
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000 | 04474naa a2200793 4500 | |
001 | oai:DiVA.org:su-79795 | |
003 | SwePub | |
008 | 120911s2012 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-797952 URI |
024 | 7 | a https://doi.org/10.1002/pro.20712 DOI |
040 | a (SwePub)su | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a for2 swepub-publicationtype |
100 | 1 | a Liberles, David A.4 aut |
245 | 1 0 | a The interface of protein structure, protein biophysics, and molecular evolution |
264 | c 2012-04-23 | |
264 | 1 | b Wiley,c 2012 |
338 | a electronic2 rdacarrier | |
520 | a The interface of protein structural biology, protein biophysics, molecular evolution, and molecular population genetics forms the foundations for a mechanistic understanding of many aspects of protein biochemistry. Current efforts in interdisciplinary protein modeling are in their infancy and the state-of-the art of such models is described. Beyond the relationship between amino acid substitution and static protein structure, protein function, and corresponding organismal fitness, other considerations are also discussed. More complex mutational processes such as insertion and deletion and domain rearrangements and even circular permutations should be evaluated. The role of intrinsically disordered proteins is still controversial, but may be increasingly important to consider. Protein geometry and protein dynamics as a deviation from static considerations of protein structure are also important. Protein expression level is known to be a major determinant of evolutionary rate and several considerations including selection at the mRNA level and the role of interaction specificity are discussed. Lastly, the relationship between modeling and needed high-throughput experimental data as well as experimental examination of protein evolution using ancestral sequence resurrection and in vitro biochemistry are presented, towards an aim of ultimately generating better models for biological inference and prediction. | |
650 | 7 | a NATURVETENSKAPx Biologix Biokemi och molekylärbiologi0 (SwePub)106022 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Biochemistry and Molecular Biology0 (SwePub)106022 hsv//eng |
653 | a evolutionary modeling | |
653 | a domain evolution | |
653 | a sequence-structure-function relationships | |
653 | a protein dynamics | |
653 | a protein thermodynamics | |
653 | a gene duplication | |
653 | a protein expression | |
653 | a ancestral sequence reconstruction | |
700 | 1 | a Teichmann, Sarah A.4 aut |
700 | 1 | a Bahar, Ivet4 aut |
700 | 1 | a Bastolla, Ugo4 aut |
700 | 1 | a Bloom, Jesse4 aut |
700 | 1 | a Bornberg-Bauer, Erich4 aut |
700 | 1 | a Colwell, Lucy J.4 aut |
700 | 1 | a de Koning, A. P. Jason4 aut |
700 | 1 | a Dokholyan, Nikolay V.4 aut |
700 | 1 | a Echave, Julian4 aut |
700 | 1 | a Elofsson, Arneu Stockholms universitet,Institutionen för biokemi och biofysik,Science for Life Laboratory (SciLifeLab)4 aut0 (Swepub:su)aelof |
700 | 1 | a Gerloff, Dietlind L.4 aut |
700 | 1 | a Goldstein, Richard A.4 aut |
700 | 1 | a Grahnen, Johan A.4 aut |
700 | 1 | a Holder, Mark T.4 aut |
700 | 1 | a Lakner, Clemens4 aut |
700 | 1 | a Lartillot, Nicholas4 aut |
700 | 1 | a Lovell, Simon C.4 aut |
700 | 1 | a Naylor, Gavin4 aut |
700 | 1 | a Perica, Tina4 aut |
700 | 1 | a Pollock, David D.4 aut |
700 | 1 | a Pupko, Tal4 aut |
700 | 1 | a Regan, Lynne4 aut |
700 | 1 | a Roger, Andrew4 aut |
700 | 1 | a Rubinstein, Nimrod4 aut |
700 | 1 | a Shakhnovich, Eugene4 aut |
700 | 1 | a Sjölander, Kimmen4 aut |
700 | 1 | a Sunyaev, Shamil4 aut |
700 | 1 | a Teufel, Ashley I.4 aut |
700 | 1 | a Thorne, Jeffrey L.4 aut |
700 | 1 | a Thornton, Joseph W.4 aut |
700 | 1 | a Weinreich, Daniel M.4 aut |
700 | 1 | a Whelan, Simon4 aut |
710 | 2 | a Stockholms universitetb Institutionen för biokemi och biofysik4 org |
773 | 0 | t Protein Scienced : Wileyg 21:6, s. 769-785q 21:6<769-785x 0961-8368x 1469-896X |
856 | 4 | u https://su.diva-portal.org/smash/get/diva2:551573/FULLTEXT02.pdfx primaryx Raw objecty fulltext:postprint |
856 | 4 | u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/pro.2071 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-79795 |
856 | 4 8 | u https://doi.org/10.1002/pro.2071 |
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