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  • Björkblom, BennyUmeå universitet,Kemiska institutionen (author)

Metabolic response patterns in brain microdialysis fluids and serum during interstitial cisplatin treatment of high-grade glioma

  • Article/chapterEnglish2020

Publisher, publication year, extent ...

  • 2019-12-10
  • Nature Publishing Group,2020
  • electronicrdacarrier

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  • LIBRIS-ID:oai:DiVA.org:umu-167291
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-167291URI
  • https://doi.org/10.1038/s41416-019-0652-xDOI

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  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • BACKGROUND: High-grade gliomas are associated with poor prognosis. Tumour heterogeneity and invasiveness create challenges for effective treatment and use of systemically administrated drugs. Furthermore, lack of functional predictive response-assays based on drug efficacy complicates evaluation of early treatment responses.METHODS: We used microdialysis to deliver cisplatin into the tumour and to monitor levels of metabolic compounds present in the tumour and non-malignant brain tissue adjacent to tumour, before and during treatment. In parallel, we collected serum samples and used multivariate statistics to analyse the metabolic effects.RESULTS: We found distinct metabolic patterns in the extracellular fluids from tumour compared to non-malignant brain tissue, including high concentrations of a wide range of amino acids, amino acid derivatives and reduced levels of monosaccharides and purine nucleosides. We found that locoregional cisplatin delivery had a strong metabolic effect at the tumour site, resulting in substantial release of glutamic acid, phosphate, and spermidine and a reduction of cysteine levels. In addition, patients with long-time survival displayed different treatment response patterns in both tumour and serum. Longer survival was associated with low tumour levels of lactic acid, glyceric acid, ketoses, creatinine and cysteine. Patients with longer survival displayed lower serum levels of ketohexoses, fatty acid methyl esters, glycerol-3-phosphate and alpha-tocopherol, while elevated phosphate levels were seen in both tumour and serum during treatment.CONCLUSION: We highlight distinct metabolic patterns associated with high-grade tumour metabolism, and responses to cytotoxic cisplatin treatment.

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  • Jonsson, PärUmeå universitet,Kemiska institutionen(Swepub:umu)parjon95 (author)
  • Tabatabaei, PedramUmeå universitet,Neurokirurgi(Swepub:umu)pemtae98 (author)
  • Bergström, PerUmeå universitet,Onkologi(Swepub:umu)pebe0049 (author)
  • Johansson, MikaelUmeå universitet,Onkologi(Swepub:umu)mijo0025 (author)
  • Asklund, ThomasUmeå universitet,Onkologi(Swepub:umu)thas0005 (author)
  • Bergenheim, A. TommyUmeå universitet,Neurokirurgi(Swepub:umu)tobe0004 (author)
  • Antti, Henrik,1970-Umeå universitet,Kemiska institutionen(Swepub:umu)hean0004 (author)
  • Umeå universitetKemiska institutionen (creator_code:org_t)

Related titles

  • In:British Journal of Cancer: Nature Publishing Group122:2, s. 221-2320007-09201532-1827

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