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Longitudinal associ...
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Gorbach, Tetiana,1991-Umeå universitet,Institutionen för integrativ medicinsk biologi (IMB),Umeå centrum för funktionell hjärnavbildning (UFBI)
(author)
Longitudinal association between hippocampus atrophy and episodic-memory decline in non-demented APOE ε4 carriers
- Article/chapterEnglish2020
Publisher, publication year, extent ...
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2020-09-28
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John Wiley & Sons,2020
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electronicrdacarrier
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LIBRIS-ID:oai:DiVA.org:umu-175957
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-175957URI
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https://doi.org/10.1002/dad2.12110DOI
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Introduction: The apolipoprotein E (APOE) ε4 allele is the main genetic risk factor for Alzheimer's disease (AD), accelerated cognitive aging, and hippocampal atrophy, but its influence on the association between hippocampus atrophy and episodic-memory decline in non-demented individuals remains unclear.Methods: We analyzed longitudinal (two to six observations) magnetic resonance imaging (MRI)–derived hippocampal volumes and episodic memory from 748 individuals (55 to 90 years at baseline, 50% female) from the European Lifebrain consortium.Results: The change-change association for hippocampal volume and memory was significant only in ε4 carriers (N = 173, r = 0.21, P = .007; non-carriers: N = 467, r = 0.073,P = .117). The linear relationship was significantly steeper for the carriers [t(629) =2.4, P = .013]. A similar trend toward a stronger change-change relation for carriers was seen in a subsample with more than two assessments.Discussion: These findings provide evidence for a difference in hippocampus-memory association between ε4 carriers and non-carriers, thus highlighting how genetic factors modulate the translation of the AD-related pathophysiological cascade into cognitive deficits.
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Pudas, Sara,Fil. Dr.1983-Umeå universitet,Institutionen för integrativ medicinsk biologi (IMB),Umeå centrum för funktionell hjärnavbildning (UFBI)(Swepub:umu)saatus02
(author)
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Bartrés-Faz, David
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Brandmaier, Andreas M.Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany; Max Planck UCL Centre for Computational Psychiatry and Ageing Research, Berlin, Germany
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Düzel, SandraCenter for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany; Max Planck UCL Centre for Computational Psychiatry and Ageing Research, Berlin, Germany
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Henson, Richard N.MRC Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, UK
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Idland, Ane-VictoriaOslo Delirium Research Group, Department of Geriatric Medicine, University of Oslo,Oslo, Norway
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Lindenberger, UlmanCenter for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany; Max Planck UCL Centre for Computational Psychiatry and Ageing Research, Berlin, Germany
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Macià Bros, DídacDepartment of Medicine, Faculty of Medicine and Health Sciences, University of Barcelona, Barcelona, Spain
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Mowinckel, Athanasia M.Center for Lifespan Changes in Brain and Cognition, University of Oslo,Oslo, Norway
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Solé-Padullés, CristinaDepartment of Medicine, Faculty of Medicine and Health Sciences, University of Barcelona, Barcelona, Spain
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Sørensen, ØysteinCenter for Lifespan Changes in Brain and Cognition, University of Oslo,Oslo, Norway
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Walhovd, Kristine B.Center for Lifespan Changes in Brain and Cognition, University of Oslo, Oslo, Norway; Department of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway
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Watne, Leiv OttoMRC Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, UK
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Westerhausen, RenéCenter for Lifespan Changes in Brain and Cognition, University of Oslo,Oslo, Norway
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Fjell, Anders M.Center for Lifespan Changes in Brain and Cognition, University of Oslo, Oslo, Norway; Department of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway
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Nyberg, Lars,1966-Umeå universitet,Diagnostisk radiologi,Institutionen för integrativ medicinsk biologi (IMB),Umeå centrum för funktionell hjärnavbildning (UFBI)(Swepub:umu)lany0001
(author)
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Umeå universitetInstitutionen för integrativ medicinsk biologi (IMB)
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In:Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring: John Wiley & Sons12:12352-8729
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