SwePub
Sök i LIBRIS databas

  Extended search

onr:"swepub:oai:DiVA.org:umu-185763"
 

Search: onr:"swepub:oai:DiVA.org:umu-185763" > The genetic organiz...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist
LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00008536naa a2200685 4500
001oai:DiVA.org:umu-185763
003SwePub
008210705s2021 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1857632 URI
0247 a https://doi.org/10.7554/eLife.664662 DOI
040 a (SwePub)umu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Fjell, Anders M.u Research Group for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Norway; Department of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway4 aut
2451 0a The genetic organization of longitudinal subcortical volumetric change is stable throughout the lifespan running title: Genetics of subcortical lifespan change
264 1b eLife Sciences Publications Ltd,c 2021
338 a electronic2 rdacarrier
520 a Development and aging of the cerebral cortex show similar topographic organization and are governed by the same genes. It is unclear whether the same is true for subcortical regions, which follow fundamentally different ontogenetic and phylogenetic principles. We tested the hypothesis that genetically governed neurodevelopmental processes can be traced throughout life by assessing to which degree brain regions that develop together continue to change together through life. Analyzing over 6000 longitudinal MRIs of the brain, we used graph theory to identify five clusters of coordinated development, indexed as patterns of correlated volumetric change in brain structures. The clusters tended to follow placement along the cranial axis in embryonic brain development, suggesting continuity from prenatal stages, and correlated with cognition. Across independent longitudinal datasets, we demonstrated that developmental clusters were conserved through life. Twin-based genetic correlations revealed distinct sets of genes governing change in each cluster. Single nucleotide polymorphisms-based analyses of 38127 cross-sectional MRIs showed a similar pattern of genetic volume-volume correlations. In conclusion, coordination of subcortical change adheres to fundamental principles of lifespan continuity and genetic organization.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng
653 a Aging
653 a Brain
653 a Development
653 a Genetics
653 a Hippocampus
653 a lifespan
653 a Subcortex
7001 a Grydeland, Håkonu Research Group for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Norway4 aut
7001 a Wang, Yunpengu Research Group for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Norway4 aut
7001 a Amlien, Ingeu Research Group for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Norway4 aut
7001 a Bartrés-Faz, Davidu Departament de Medicina, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona, and Institut de Neurociències, Universitat de Barcelona, Spain4 aut
7001 a Brandmaier, Andreas M.u Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany; Max Planck, UCL Centre for Computational Psychiatry and Ageing Research, Berlin, Germany; Max Planck, UCL Centre for Computational Psychiatry and Ageing Research, London, United Kingdom4 aut
7001 a Düzel, Sandrau Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany4 aut
7001 a Elman, Jeremyu Center for Behavioral Genomics Twin Research Laboratory, University of California, La Jolla, CA, San Diego, United States; Department of Psychiatry, University of California, La Jolla, San Diego, United States4 aut
7001 a Franz, Carolu Center for Behavioral Genomics Twin Research Laboratory, University of California, La Jolla, CA, San Diego, United States; Department of Psychiatry, University of California, La Jolla, San Diego, United States4 aut
7001 a Håberg, Asta K.u Department of Medical Imaging, St. Olav's Hospital, Trondheim, Norway; Department of Neuroscience, Norwegian University of Science and Technology (NTNU), Trondheim, Norway4 aut
7001 a Kietzmann, Tim C.u MRC Cognition and Brain Sciences Unit, University of Cambridge, United Kingdom; Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, Netherlands4 aut
7001 a Kievit, Rogier A.u MRC Cognition and Brain Sciences Unit, University of Cambridge, United Kingdom4 aut
7001 a Kremen, William S.u Center of Excellence for Stress and Mental Health, VA San Diego Healthcare System, La Jolla, CA, United States; Center for Behavioral Genomics Twin Research Laboratory, University of California, La Jolla, CA, San Diego, United States; Department of Psychiatry, University of California, La Jolla, San Diego, United States4 aut
7001 a Krogsrud, Stine K.u Research Group for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Norway4 aut
7001 a Kühn, Simoneu Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany; Lise Meitner Group for Environmental Neuroscience, Max Planck Institute for Human Development, Berlin, Germany4 aut
7001 a Lindenberger, Ulmanu Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany; Max Planck, UCL Centre for Computational Psychiatry and Ageing Research, Berlin, Germany; Max Planck, UCL Centre for Computational Psychiatry and Ageing Research, London, United Kingdom4 aut
7001 a Macià, Didacu Departament de Medicina, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona, and Institut de Neurociències, Universitat de Barcelona, Spain4 aut
7001 a Mowinckel, Athanasia M.u Research Group for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Norway4 aut
7001 a Nyberg, Lars,d 1966-u Umeå universitet,Umeå centrum för funktionell hjärnavbildning (UFBI),Institutionen för strålningsvetenskaper,Center for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway4 aut0 (Swepub:umu)lany0001
7001 a Panizzon, Matthew S.u Center for Behavioral Genomics Twin Research Laboratory, University of California, La Jolla, CA, San Diego, United States; Department of Psychiatry, University of California, La Jolla, San Diego, United States4 aut
7001 a Solé-Padullés, Cristinau Departament de Medicina, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona, and Institut de Neurociències, Universitat de Barcelona, Spain4 aut
7001 a Sørensen, Øysteinu Research Group for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Norway4 aut
7001 a Westerhausen, Renéu Research Group for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Norway4 aut
7001 a Walhovd, Kristine B.u Research Group for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Norway; Department of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway4 aut
7102 a Research Group for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Norway; Department of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norwayb Research Group for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Norway4 org
7730 t eLIFEd : eLife Sciences Publications Ltdg 10q 10x 2050-084X
8564 u https://doi.org/10.7554/eLife.66466y Fulltext
8564 u https://umu.diva-portal.org/smash/get/diva2:1577904/FULLTEXT02.pdfx primaryx Raw objecty fulltext:print
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-185763
8564 8u https://doi.org/10.7554/eLife.66466

Find in a library

  • eLIFE (Search for host publication in LIBRIS)

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view