Search: onr:"swepub:oai:DiVA.org:umu-25443" >
Genome-wide associa...
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Amundadottir, Laufey
(author)
Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer.
- Article/chapterEnglish2009
Publisher, publication year, extent ...
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2009-08-02
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Springer Science and Business Media LLC,2009
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:umu-25443
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-25443URI
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https://doi.org/10.1038/ng.429DOI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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We conducted a two-stage genome-wide association study of pancreatic cancer, a cancer with one of the lowest survival rates worldwide. We genotyped 558,542 SNPs in 1,896 individuals with pancreatic cancer and 1,939 controls drawn from 12 prospective cohorts plus one hospital-based case-control study. We conducted a combined analysis of these groups plus an additional 2,457 affected individuals and 2,654 controls from eight case-control studies, adjusting for study, sex, ancestry and five principal components. We identified an association between a locus on 9q34 and pancreatic cancer marked by the SNP rs505922 (combined P = 5.37 x 10(-8); multiplicative per-allele odds ratio 1.20; 95% confidence interval 1.12-1.28). This SNP maps to the first intron of the ABO blood group gene. Our results are consistent with earlier epidemiologic evidence suggesting that people with blood group O may have a lower risk of pancreatic cancer than those with groups A or B.
Added entries (persons, corporate bodies, meetings, titles ...)
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Kraft, Peter
(author)
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Stolzenberg-Solomon, Rachael Z
(author)
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Fuchs, Charles S
(author)
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Petersen, Gloria M
(author)
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Arslan, Alan A
(author)
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Bueno-de-Mesquita, H Bas
(author)
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Gross, Myron
(author)
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Helzlsouer, Kathy
(author)
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Jacobs, Eric J
(author)
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Lacroix, Andrea
(author)
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Zheng, Wei
(author)
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Albanes, Demetrius
(author)
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Bamlet, William
(author)
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Berg, Christine D
(author)
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Berrino, Franco
(author)
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Bingham, Sheila
(author)
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Buring, Julie E
(author)
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Bracci, Paige M
(author)
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Canzian, Federico
(author)
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Clavel-Chapelon, Françoise
(author)
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Clipp, Sandra
(author)
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Cotterchio, Michelle
(author)
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de Andrade, Mariza
(author)
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Duell, Eric J
(author)
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Fox Jr, John W
(author)
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Gallinger, Steven
(author)
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Gaziano, J Michael
(author)
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Giovannucci, Edward L
(author)
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Goggins, Michael
(author)
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González, Carlos A
(author)
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Hallmans, GöranUmeå universitet,Näringsforskning(Swepub:umu)goha0001
(author)
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Hankinson, Susan E
(author)
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Hassan, Manal
(author)
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Holly, Elizabeth A
(author)
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Hunter, David J
(author)
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Hutchinson, Amy
(author)
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Jackson, Rebecca
(author)
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Jacobs, Kevin B
(author)
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Jenab, Mazda
(author)
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Kaaks, Rudolf
(author)
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Klein, Alison P
(author)
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Kooperberg, Charles
(author)
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Kurtz, Robert C
(author)
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Li, Donghui
(author)
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Lynch, Shannon M
(author)
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Mandelson, Margaret
(author)
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McWilliams, Robert R
(author)
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Mendelsohn, Julie B
(author)
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Michaud, Dominique S
(author)
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Olson, Sara H
(author)
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Overvad, Kim
(author)
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Patel, Alpa V
(author)
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Peeters, Petra H M
(author)
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Rajkovic, Aleksandar
(author)
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Riboli, Elio
(author)
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Risch, Harvey A
(author)
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Shu, Xiao-Ou
(author)
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Thomas, Gilles
(author)
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Tobias, Geoffrey S
(author)
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Trichopoulos, Dimitrios
(author)
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Van Den Eeden, Stephen K
(author)
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Virtamo, Jarmo
(author)
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Wactawski-Wende, Jean
(author)
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Wolpin, Brian M
(author)
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Yu, Herbert
(author)
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Yu, Kai
(author)
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Zeleniuch-Jacquotte, Anne
(author)
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Chanock, Stephen J
(author)
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Hartge, Patricia
(author)
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Hoover, Robert N
(author)
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Umeå universitetNäringsforskning
(creator_code:org_t)
Related titles
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In:Nature Genetics: Springer Science and Business Media LLC41, s. 986-9901061-40361546-1718
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- By the author/editor
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Kraft, Peter
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Nature Genetics
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Umeå University