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A genome-wide assoc...
A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33
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Petersen, Gloria M (author)
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Amundadottir, Laufey (author)
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Fuchs, Charles S (author)
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show more...
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Kraft, Peter (author)
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Stolzenberg-Solomon, Rachael Z (author)
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Jacobs, Kevin B (author)
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Arslan, Alan A (author)
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Bueno-de-Mesquita, H Bas (author)
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Gallinger, Steven (author)
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Gross, Myron (author)
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Helzlsouer, Kathy (author)
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Holly, Elizabeth A (author)
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Jacobs, Eric J (author)
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Klein, Alison P (author)
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LaCroix, Andrea (author)
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Li, Donghui (author)
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Mandelson, Margaret T (author)
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Olson, Sara H (author)
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Risch, Harvey A (author)
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Zheng, Wei (author)
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Albanes, Demetrius (author)
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Bamlet, William R (author)
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Berg, Christine D (author)
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Boutron-Ruault, Marie-Christine (author)
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Buring, Julie E (author)
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Bracci, Paige M (author)
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Canzian, Federico (author)
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Clipp, Sandra (author)
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Cotterchio, Michelle (author)
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de Andrade, Mariza (author)
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Duell, Eric J (author)
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Gaziano, J Michael (author)
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Giovannucci, Edward L (author)
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Goggins, Michael (author)
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- Hallmans, Göran, 1947- (author)
- Umeå universitet,Institutionen för folkhälsa och klinisk medicin,Näringsforskning
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Hankinson, Susan E (author)
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Hassan, Manal (author)
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Howard, Barbara (author)
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Hunter, David J (author)
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Hutchinson, Amy (author)
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Jenab, Mazda (author)
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Kaaks, Rudolf (author)
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Kooperberg, Charles (author)
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Krogh, Vittorio (author)
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Kurtz, Robert C (author)
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Lynch, Shannon M (author)
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McWilliams, Robert R (author)
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Mendelsohn, Julie B (author)
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Michaud, Dominique S (author)
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Parikh, Hemang (author)
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Patel, Alpa V (author)
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Peeters, Petra H M (author)
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Rajkovic, Aleksandar (author)
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Riboli, Elio (author)
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Rodriguez, Laudina (author)
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Seminara, Daniela (author)
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Shu, Xiao-Ou (author)
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Thomas, Gilles (author)
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Tjønneland, Anne (author)
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Tobias, Geoffrey S (author)
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Trichopoulos, Dimitrios (author)
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Van Den Eeden, Stephen K (author)
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Virtamo, Jarmo (author)
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Wactawski-Wende, Jean (author)
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Wang, Zhaoming (author)
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Wolpin, Brian M (author)
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Yu, Herbert (author)
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Yu, Kai (author)
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Zeleniuch-Jacquotte, Anne (author)
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Fraumeni, Joseph F (author)
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Hoover, Robert N (author)
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Hartge, Patricia (author)
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Chanock, Stephen J (author)
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(creator_code:org_t)
- 2010-01-24
- 2010
- English.
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In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 42:3, s. 224-228
- Related links:
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https://europepmc.or...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- We conducted a genome-wide association study of pancreatic cancer in 3,851 affected individuals (cases) and 3,934 unaffected controls drawn from 12 prospective cohort studies and 8 case-control studies. Based on a logistic regression model for genotype trend effect that was adjusted for study, age, sex, self-described ancestry and five principal components, we identified eight SNPs that map to three loci on chromosomes 13q22.1, 1q32.1 and 5p15.33. Two correlated SNPs, rs9543325 (P = 3.27 x 10(-11), per-allele odds ratio (OR) 1.26, 95% CI 1.18-1.35) and rs9564966 (P = 5.86 x 10(-8), per-allele OR 1.21, 95% CI 1.13-1.30), map to a nongenic region on chromosome 13q22.1. Five SNPs on 1q32.1 map to NR5A2, and the strongest signal was at rs3790844 (P = 2.45 x 10(-10), per-allele OR 0.77, 95% CI 0.71-0.84). A single SNP, rs401681 (P = 3.66 x 10(-7), per-allele OR 1.19, 95% CI 1.11-1.27), maps to the CLPTM1L-TERT locus on 5p15.33, which is associated with multiple cancers. Our study has identified common susceptibility loci for pancreatic cancer that warrant follow-up studies.
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- By the author/editor
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Petersen, Gloria ...
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Amundadottir, La ...
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Fuchs, Charles S
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Kraft, Peter
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Stolzenberg-Solo ...
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Jacobs, Kevin B
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show more...
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Arslan, Alan A
-
Bueno-de-Mesquit ...
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Gallinger, Steve ...
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Gross, Myron
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Helzlsouer, Kath ...
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Holly, Elizabeth ...
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Jacobs, Eric J
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Klein, Alison P
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LaCroix, Andrea
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Li, Donghui
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Mandelson, Marga ...
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Olson, Sara H
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Risch, Harvey A
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Zheng, Wei
-
Albanes, Demetri ...
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Bamlet, William ...
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Berg, Christine ...
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Boutron-Ruault, ...
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Buring, Julie E
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Bracci, Paige M
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Canzian, Federic ...
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Clipp, Sandra
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Cotterchio, Mich ...
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de Andrade, Mari ...
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Duell, Eric J
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Gaziano, J Micha ...
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Giovannucci, Edw ...
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Goggins, Michael
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Hallmans, Göran, ...
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Hankinson, Susan ...
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Hassan, Manal
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Howard, Barbara
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Hunter, David J
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Hutchinson, Amy
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Jenab, Mazda
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Kaaks, Rudolf
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Kooperberg, Char ...
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Krogh, Vittorio
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Kurtz, Robert C
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Lynch, Shannon M
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McWilliams, Robe ...
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Mendelsohn, Juli ...
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Michaud, Dominiq ...
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Parikh, Hemang
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Patel, Alpa V
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Peeters, Petra H ...
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Rajkovic, Aleksa ...
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Riboli, Elio
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Rodriguez, Laudi ...
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Seminara, Daniel ...
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Shu, Xiao-Ou
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Thomas, Gilles
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Tjønneland, Anne
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Tobias, Geoffrey ...
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Trichopoulos, Di ...
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Van Den Eeden, S ...
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Virtamo, Jarmo
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Wactawski-Wende, ...
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Wang, Zhaoming
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Wolpin, Brian M
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Yu, Herbert
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Yu, Kai
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Zeleniuch-Jacquo ...
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Fraumeni, Joseph ...
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Hoover, Robert N
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Hartge, Patricia
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Chanock, Stephen ...
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show less...
- Articles in the publication
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Nature Genetics
- By the university
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Umeå University