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Polymorphisms in th...
Polymorphisms in the genes of the urokinase plasminogen activation system in relation to colorectal cancer
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Försti, A (author)
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Lei, H (author)
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- Tavelin, Björn (author)
- Norrlands University Hospital
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- Enquist, K (author)
- Umeå universitet,Näringsforskning
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- Palmqvist, Richard (author)
- Umeå universitet,Patologi
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Altieri, A (author)
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- Hallmans, Göran, 1947- (author)
- Umeå universitet,Näringsforskning
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Hemminki, K (author)
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- Lenner, Per (author)
- Norrlands University Hospital
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(creator_code:org_t)
- Oxford University Press, 2007
- 2007
- English.
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In: Annals of Oncology. - : Oxford University Press. - 0923-7534 .- 1569-8041. ; 18:12, s. 1990-1994
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
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- Background: Extracellular matrix degradation, mediated by the urokinase plasminogen activation (uPA) system, is a critical step in tumor invasion and metastasis. High tumor levels of uPA and its inhibitor PAI-1 have been correlated with poor cancer prognosis. We examined four single nucleotide polymorphisms (SNPs) with a potential effect on expression of genes in the uPA system for their role in colorectal cancer susceptibility and prognosis.Patients and methods: We genotyped the SNPs in 308 Swedish incident colorectal cancer patients with up to 16 years of follow-up and in 585 age- and sex-matched controls. We evaluated the associations between genotypes and colorectal cancer and Dukes' stage. Survival probabilities were compared between different subgroups.Results: Patients with PAI-1 –675 5G/5G genotype had better survival than patients with 4G/4G or 4G/5G genotypes when they had Dukes' stage A or B tumors (P = 0.023 and P = 0.015, respectively). No statistically significant association was observed between the SNPs and the risk of colorectal cancer or Dukes' stage.Conclusions: Our results suggest a role for the PAI-1 genotype in colorectal cancer prognosis, but further studies are needed to evaluate the impact of our finding in the clinic.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- colorectal cancer
- PAI-1
- prognostic biomarker
- single nucleotide polymorphism
- uPA system
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Försti, A
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Lei, H
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Tavelin, Björn
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Enquist, K
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Palmqvist, Richa ...
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Altieri, A
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show more...
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Hallmans, Göran, ...
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Hemminki, K
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Lenner, Per
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Annals of Oncolo ...
- By the university
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Umeå University
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Karolinska Institutet