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Ischemic stroke is ...
Ischemic stroke is associated with the ABO locus : the EuroCLOT study
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Williams, Frances M. K. (author)
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Carter, Angela M. (author)
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Hysi, Pirro G. (author)
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Surdulescu, Gabriela (author)
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Hodgkiss, Dylan (author)
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Soranzo, Nicole (author)
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Traylor, Matthew (author)
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Bevan, Steve (author)
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Dichgans, Martin (author)
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Rothwell, Peter M. W. (author)
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Sudlow, Cathie (author)
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Farrall, Martin (author)
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Silander, Kaisa (author)
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Kaunisto, Mari (author)
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Wagner, Peter (author)
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Saarela, Olli (author)
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Kuulasmaa, Kari (author)
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Virtamo, Jarmo (author)
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Salomaa, Veikko (author)
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Amouyel, Philippe (author)
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Arveiler, Dominique (author)
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Ferrieres, Jean (author)
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- Wiklund, Per-Gunnar (author)
- Umeå universitet,Medicin
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Ikram, M. Arfan (author)
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Hofman, Albert (author)
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Boncoraglio, Giorgio B. (author)
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Parati, Eugenio A. (author)
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Helgadottir, Anna (author)
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Gretarsdottir, Solveig (author)
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Thorsteinsdottir, Unnur (author)
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Thorleifsson, Gudmar (author)
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Stefansson, Kari (author)
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Seshadri, Sudha (author)
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DeStefano, Anita (author)
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Gschwendtner, Andreas (author)
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Psaty, Bruce (author)
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Longstreth, Will (author)
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Mitchell, Braxton D. (author)
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Cheng, Yu-Ching (author)
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Clarke, Robert (author)
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Ferrario, Marco (author)
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Bis, Joshua C. (author)
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Levi, Christopher (author)
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Attia, John (author)
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Holliday, Elizabeth G. (author)
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Scott, Rodney J. (author)
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Fornage, Myriam (author)
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Sharma, Pankaj (author)
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Furie, Karen L. (author)
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Rosand, Jonathan (author)
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Nalls, Mike (author)
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Meschia, James (author)
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Mosely, Thomas H. (author)
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Evans, Alun (author)
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Palotie, Aarno (author)
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Markus, Hugh S. (author)
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Grant, Peter J. (author)
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Spector, Tim D. (author)
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(creator_code:org_t)
- 2013-02-04
- 2013
- English.
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In: Annals of Neurology. - : Wiley-Blackwell. - 0364-5134 .- 1531-8249. ; 73:1, s. 16-31
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https://onlinelibrar...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Objective: End-stage coagulation and the structure/function of fibrin are implicated in the pathogenesis of ischemic stroke. We explored whether genetic variants associated with end-stage coagulation in healthy volunteers account for the genetic predisposition to ischemic stroke and examined their influence on stroke subtype. Methods: Common genetic variants identified through genome-wide association studies of coagulation factors and fibrin structure/function in healthy twins (n = 2,100, Stage 1) were examined in ischemic stroke (n = 4,200 cases) using 2 independent samples of European ancestry (Stage 2). A third clinical collection having stroke subtyping (total 8,900 cases, 55,000 controls) was used for replication (Stage 3). Results: Stage 1 identified 524 single nucleotide polymorphisms (SNPs) from 23 linkage disequilibrium blocks having significant association (p < 5 x 10(-8)) with 1 or more coagulation/fibrin phenotypes. The most striking associations included SNP rs5985 with factor XIII activity (p = 2.6 x 10(-186)), rs10665 with FVII (p = 2.4 x 10(-47)), and rs505922 in the ABO gene with both von Willebrand factor (p = 4.7 x 10(-57)) and factor VIII (p = 1.2 x 10(-36)). In Stage 2, the 23 independent SNPs were examined in stroke cases/noncases using MOnica Risk, Genetics, Archiving and Monograph (MORGAM) and Wellcome Trust Case Control Consortium 2 collections. SNP rs505922 was nominally associated with ischemic stroke (odds ratio = 0.94, 95% confidence interval = 0.88-0.99, p = 0.023). Independent replication in Meta-Stroke confirmed the rs505922 association with stroke, beta (standard error, SE) = 0.066 (0.02), p = 0.001, a finding specific to large-vessel and cardioembolic stroke (p = 0.001 and p = < 0.001, respectively) but not seen with small-vessel stroke (p = 0.811). Interpretation: ABO gene variants are associated with large-vessel and cardioembolic stroke but not small-vessel disease. This work sheds light on the different pathogenic mechanisms underpinning stroke subtype.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Williams, France ...
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Carter, Angela M ...
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Hysi, Pirro G.
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Surdulescu, Gabr ...
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Hodgkiss, Dylan
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Soranzo, Nicole
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show more...
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Traylor, Matthew
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Bevan, Steve
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Dichgans, Martin
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Rothwell, Peter ...
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Sudlow, Cathie
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Farrall, Martin
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Silander, Kaisa
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Kaunisto, Mari
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Wagner, Peter
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Saarela, Olli
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Kuulasmaa, Kari
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Virtamo, Jarmo
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Salomaa, Veikko
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Amouyel, Philipp ...
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Arveiler, Domini ...
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Ferrieres, Jean
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Wiklund, Per-Gun ...
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Ikram, M. Arfan
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Hofman, Albert
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Boncoraglio, Gio ...
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Parati, Eugenio ...
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Helgadottir, Ann ...
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Gretarsdottir, S ...
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Thorsteinsdottir ...
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Thorleifsson, Gu ...
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Stefansson, Kari
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Seshadri, Sudha
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DeStefano, Anita
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Gschwendtner, An ...
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Psaty, Bruce
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Longstreth, Will
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Mitchell, Braxto ...
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Cheng, Yu-Ching
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Clarke, Robert
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Ferrario, Marco
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Bis, Joshua C.
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Levi, Christophe ...
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Attia, John
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Holliday, Elizab ...
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Scott, Rodney J.
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Fornage, Myriam
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Sharma, Pankaj
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Furie, Karen L.
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Rosand, Jonathan
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Nalls, Mike
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Meschia, James
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Mosely, Thomas H ...
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Evans, Alun
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Palotie, Aarno
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Markus, Hugh S.
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Grant, Peter J.
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Spector, Tim D.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
- Articles in the publication
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Annals of Neurol ...
- By the university
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Umeå University