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H63D polymorphism i...
H63D polymorphism in HFE is not associated with amyotrophic lateral sclerosis
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van Rheenen, Wouter (author)
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Diekstra, Frank P (author)
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van Doormaal, Perry TC (author)
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Seelen, Meinie (author)
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Kenna, Kevin (author)
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McLaughlin, Russell (author)
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Shatunov, Aleksey (author)
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Czell, David (author)
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van Es, Michael A (author)
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van Vught, Paul WJ (author)
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van Damme, Philip (author)
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Smith, Bradley N (author)
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Waibel, Stefan (author)
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Schelhaas, H Jurgen (author)
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van der Kooi, Anneke J (author)
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de Visser, Marianne (author)
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Weber, Markus (author)
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Robberecht, Wim (author)
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Hardiman, Orla (author)
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Shawi, Pamela J (author)
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Shaw, Christopher E (author)
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Morrison, Karen E (author)
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Al-Chalabi, Ammar (author)
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- Andersen, Peter M (author)
- Umeå universitet,Klinisk neurovetenskap
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Ludolph, Albert C (author)
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Veldink, Jan H (author)
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van den Berg, Leonard H (author)
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(creator_code:org_t)
- Elsevier BV, 2013
- 2013
- English.
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In: Neurobiology of Aging. - : Elsevier BV. - 0197-4580 .- 1558-1497. ; 34:5, s. 1517.e5-1517.e7
- Related links:
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https://lirias.kuleu...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- The H63D polymorphism in HFE has frequently been associated with susceptibility to amyotrophic lateral sclerosis (ALS). Regarding the role of HFE in iron homeostasis, iron accumulation is considered an important process in ALS. Furthermore, novel therapeutic strategies are being developed targeting this process. Evidence for this genetic association is, however, limited to several small studies. For this reason we studied the H63D polymorphism in a large European cohort including 3962 ALS patients and 5072 control subjects from 7 countries. After meta-analysis of previous studies and current findings we conclude that the H63D polymorphism in HFE is not associated with susceptibility to ALS, age at disease onset, or survival. (C) 2013 Elsevier Inc. All rights reserved.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Geriatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Geriatrics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- Amyotrophic lateral sclerosis (ALS)
- Motor neuron disease (MND)
- HFE
- H63D
- rs1799945
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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van Rheenen, Wou ...
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Diekstra, Frank ...
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van Doormaal, Pe ...
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Seelen, Meinie
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Kenna, Kevin
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McLaughlin, Russ ...
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show more...
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Shatunov, Alekse ...
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Czell, David
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van Es, Michael ...
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van Vught, Paul ...
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van Damme, Phili ...
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Smith, Bradley N
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Waibel, Stefan
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Schelhaas, H Jur ...
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van der Kooi, An ...
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de Visser, Maria ...
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Weber, Markus
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Robberecht, Wim
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Hardiman, Orla
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Shawi, Pamela J
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Shaw, Christophe ...
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Morrison, Karen ...
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Al-Chalabi, Amma ...
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Andersen, Peter ...
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Ludolph, Albert ...
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Veldink, Jan H
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van den Berg, Le ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Geriatrics
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
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Neurobiology of ...
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Umeå University