Search: onr:"swepub:oai:DiVA.org:umu-95215" >
Combined impact of ...
Combined impact of healthy lifestyle factors on colorectal cancer : a large European cohort study
-
Aleksandrova, Krasimira (author)
-
Pischon, Tobias (author)
-
Jenab, Mazda (author)
-
show more...
-
Bueno-de-Mesquita, H Bas (author)
-
Fedirko, Veronika (author)
-
Norat, Teresa (author)
-
Romaguera, Dora (author)
-
Knüppel, Sven (author)
-
Boutron-Ruault, Marie-Christine (author)
-
Dossus, Laure (author)
-
Dartois, Laureen (author)
-
Kaaks, Rudolf (author)
-
Li, Kuanrong (author)
-
Tjønneland, Anne (author)
-
Overvad, Kim (author)
-
Quirós, José Ramón (author)
-
Buckland, Genevieve (author)
-
Sánchez, María José (author)
-
Dorronsoro, Miren (author)
-
Chirlaque, Maria-Dolores (author)
-
Barricarte, Aurelio (author)
-
Khaw, Kay-Tee (author)
-
Wareham, Nicholas J (author)
-
Bradbury, Kathryn E (author)
-
Trichopoulou, Antonia (author)
-
Lagiou, Pagona (author)
-
Trichopoulos, Dimitrios (author)
-
Palli, Domenico (author)
-
Krogh, Vittorio (author)
-
Tumino, Rosario (author)
-
Naccarati, Alessio (author)
-
Panico, Salvatore (author)
-
Siersema, Peter D (author)
-
Peeters, Petra HM (author)
-
- Ljuslinder, Ingrid (author)
- Umeå universitet,Onkologi
-
- Johansson, Ingegerd (author)
- Umeå universitet,Institutionen för odontologi
-
- Ericson, Ulrika (author)
- Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups
-
- Ohlsson, Bodil (author)
- Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups
-
- Weiderpass, Elisabete (author)
- Karolinska Institutet
-
Skeie, Guri (author)
-
Borch, Kristin (author)
-
Rinaldi, Sabina (author)
-
Romieu, Isabelle (author)
-
Kong, Joyce (author)
-
Gunter, Marc J (author)
-
Ward, Heather A (author)
-
Riboli, Elio (author)
-
Boeing, Heiner (author)
-
show less...
-
(creator_code:org_t)
- 2014-10-10
- 2014
- English.
-
In: BMC Medicine. - : BioMed Central. - 1741-7015. ; 12:1, s. 168-
- Related links:
-
https://umu.diva-por... (primary) (Raw object)
-
show more...
-
https://bmcmedicine....
-
https://portal.resea... (primary) (free)
-
http://dx.doi.org/10... (free)
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
https://lup.lub.lu.s...
-
http://kipublication...
-
show less...
Abstract
Subject headings
Close
- BACKGROUND: Excess body weight, physical activity, smoking, alcohol consumption and certain dietary factors are individually related to colorectal cancer (CRC) risk; however, little is known about their joint effects. The aim of this study was to develop a healthy lifestyle index (HLI) composed of five potentially modifiable lifestyle factors - healthy weight, physical activity, non-smoking, limited alcohol consumption and a healthy diet, and to explore the association of this index with CRC incidence using data collected within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. METHODS: In the EPIC cohort, a total of 347,237 men and women, 25- to 70-years old, provided dietary and lifestyle information at study baseline (1992 to 2000). Over a median follow-up time of 12 years, 3,759 incident CRC cases were identified. The association between a HLI and CRC risk was evaluated using Cox proportional hazards regression models and population attributable risks (PARs) have been calculated. RESULTS: After accounting for study centre, age, sex and education, compared with 0 or 1 healthy lifestyle factors, the hazard ratio (HR) for CRC was 0.87 (95% confidence interval (CI): 0.44 to 0.77) for two factors, 0.79 (95% CI: 0.70 to 0.89) for three factors, 0.66 (95% CI: 0.58 to 0.75) for four factors and 0.63 (95% CI: 0.54 to 0.74) for five factors; P-trend <0.0001. The associations were present for both colon and rectal cancers, HRs, 0.61 (95% CI: 0.50 to 0.74; P for trend <0.0001) for colon cancer and 0.68 (95% CI: 0.53 to 0.88; P-trend <0.0001) for rectal cancer, respectively (P-difference by cancer sub-site = 0.10). Overall, 16% of the new CRC cases (22% in men and 11% in women) were attributable to not adhering to a combination of all five healthy lifestyle behaviours included in the index. CONCLUSIONS: Combined lifestyle factors are associated with a lower incidence of CRC in European populations characterized by western lifestyles. Prevention strategies considering complex targeting of multiple lifestyle factors may provide practical means for improved CRC prevention.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Keyword
- acrylamide
- dietary questionnaires
- haemoglobin adducts
- biomarkers
- smoking
- measurement errors
- lifestyle factors
- combined impact
- population attributable risks
- colorectal cancer
- European Prospective Investigation into Cancer and Nutrition (EPIC)
- lifestyle factors
- combined impact
- population attributable risks
- colorectal cancer
- European Prospective Investigation into Cancer and
- Nutrition (EPIC)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Aleksandrova, Kr ...
-
Pischon, Tobias
-
Jenab, Mazda
-
Bueno-de-Mesquit ...
-
Fedirko, Veronik ...
-
Norat, Teresa
-
show more...
-
Romaguera, Dora
-
Knüppel, Sven
-
Boutron-Ruault, ...
-
Dossus, Laure
-
Dartois, Laureen
-
Kaaks, Rudolf
-
Li, Kuanrong
-
Tjønneland, Anne
-
Overvad, Kim
-
Quirós, José Ram ...
-
Buckland, Genevi ...
-
Sánchez, María J ...
-
Dorronsoro, Mire ...
-
Chirlaque, Maria ...
-
Barricarte, Aure ...
-
Khaw, Kay-Tee
-
Wareham, Nichola ...
-
Bradbury, Kathry ...
-
Trichopoulou, An ...
-
Lagiou, Pagona
-
Trichopoulos, Di ...
-
Palli, Domenico
-
Krogh, Vittorio
-
Tumino, Rosario
-
Naccarati, Aless ...
-
Panico, Salvator ...
-
Siersema, Peter ...
-
Peeters, Petra H ...
-
Ljuslinder, Ingr ...
-
Johansson, Ingeg ...
-
Ericson, Ulrika
-
Ohlsson, Bodil
-
Weiderpass, Elis ...
-
Skeie, Guri
-
Borch, Kristin
-
Rinaldi, Sabina
-
Romieu, Isabelle
-
Kong, Joyce
-
Gunter, Marc J
-
Ward, Heather A
-
Riboli, Elio
-
Boeing, Heiner
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Health Sciences
-
and Public Health Gl ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Cancer and Oncol ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Endocrinology an ...
- Articles in the publication
-
BMC Medicine
- By the university
-
Umeå University
-
Lund University
-
Karolinska Institutet