Search: onr:"swepub:oai:DiVA.org:umu-96520" >
Genome-wide interac...
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Figueroa, Jonine D.
(author)
Genome-wide interaction study of smoking and bladder cancer risk
- Article/chapterEnglish2014
Publisher, publication year, extent ...
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2014-03-24
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Oxford University Press,2014
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:umu-96520
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-96520URI
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https://doi.org/10.1093/carcin/bgu064DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:129950353URI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Bladder cancer is a complex disease with known environmental and genetic risk factors. We performed a genome-wide interaction study (GWAS) of smoking and bladder cancer risk based on primary scan data from 3002 cases and 4411 controls from the National Cancer Institute Bladder Cancer GWAS. Alternative methods were used to evaluate both additive and multiplicative interactions between individual single nucleotide polymorphisms (SNPs) and smoking exposure. SNPs with interaction P values < 5 x 10(-5) were evaluated further in an independent dataset of 2422 bladder cancer cases and 5751 controls. We identified 10 SNPs that showed association in a consistent manner with the initial dataset and in the combined dataset, providing evidence of interaction with tobacco use. Further, two of these novel SNPs showed strong evidence of association with bladder cancer in tobacco use subgroups that approached genome-wide significance. Specifically, rs1711973 (FOXF2) on 6p25.3 was a susceptibility SNP for never smokers [combined odds ratio (OR) = 1.34, 95% confidence interval (CI) = 1.20-1.50, P value = 5.18 x 10(-7)]; and rs12216499 (RSPH3-TAGAP-EZR) on 6q25.3 was a susceptibility SNP for ever smokers (combined OR = 0.75, 95% CI = 0.67-0.84, P value = 6.35 x 10-7). In our analysis of smoking and bladder cancer, the tests for multiplicative interaction seemed to more commonly identify susceptibility loci with associations in never smokers, whereas the additive interaction analysis identified more loci with associations among smokers-including the known smoking and NAT2 acetylation interaction. Our findings provide additional evidence of gene-environment interactions for tobacco and bladder cancer.
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Han, Summer S.
(author)
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Garcia-Closas, Montserrat
(author)
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Baris, Dalsu
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Jacobs, Eric J.
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Kogevinas, Manolis
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Schwenn, Molly
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Malats, Nuria
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Johnson, Alison
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Purdue, Mark P.
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Caporaso, Neil
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Landi, Maria Teresa
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Prokunina-Olsson, Ludmila
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Wang, Zhaoming
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Hutchinson, Amy
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Burdette, Laurie
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Wheeler, William
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Vineis, Paolo
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Siddiq, Afshan
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Cortessis, Victoria K.
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Kooperberg, Charles
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Cussenot, Olivier
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Benhamou, Simone
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Prescott, Jennifer
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Porru, Stefano
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Bueno-de-Mesquita, H. Bas
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Trichopoulos, Dimitrios
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Ljungberg, BörjeUmeå universitet,Urologi och andrologi,Njurcancer(Swepub:umu)bolj0001
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Clavel-Chapelon, Françoise
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Weiderpass, ElisabeteKarolinska Institutet
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Krogh, Vittorio
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Dorronsoro, Miren
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Travis, Ruth
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Tjønneland, Anne
(author)
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Brenan, Paul
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Chang-Claude, Jenny
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Riboli, Elio
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Conti, David
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Gago-Dominguez, Manuela
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Stern, Mariana C.
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De Vivo, Immaculata
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Giovannucci, Edward
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Pavanello, Sofia
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Mastrangelo, Giuseppe
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Karagas, Margaret R.
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Schned, Alan
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Armenti, Karla R.
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Hosain, G. M. Monawar
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Haiman, Chris A.
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Fraumeni, Joseph F., Jr.
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Chanock, Stephen J.
(author)
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Chatterjee, Nilanjan
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Rothman, Nathaniel
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Silverman, Debra T.
(author)
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Umeå universitetUrologi och andrologi
(creator_code:org_t)
Related titles
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In:Carcinogenesis: Oxford University Press35:8, s. 1737-17440143-33341460-2180
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Figueroa, Jonine ...
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Han, Summer S.
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Garcia-Closas, M ...
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Baris, Dalsu
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Jacobs, Eric J.
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Kogevinas, Manol ...
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show more...
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Schwenn, Molly
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Malats, Nuria
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Johnson, Alison
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Purdue, Mark P.
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Caporaso, Neil
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Landi, Maria Ter ...
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Prokunina-Olsson ...
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Wang, Zhaoming
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Hutchinson, Amy
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Burdette, Laurie
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Wheeler, William
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Vineis, Paolo
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Siddiq, Afshan
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Cortessis, Victo ...
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Kooperberg, Char ...
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Cussenot, Olivie ...
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Benhamou, Simone
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Prescott, Jennif ...
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Porru, Stefano
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Bueno-de-Mesquit ...
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Trichopoulos, Di ...
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Ljungberg, Börje
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Clavel-Chapelon, ...
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Weiderpass, Elis ...
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Krogh, Vittorio
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Dorronsoro, Mire ...
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Travis, Ruth
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Tjønneland, Anne
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Brenan, Paul
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Chang-Claude, Je ...
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Riboli, Elio
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Conti, David
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Gago-Dominguez, ...
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Stern, Mariana C ...
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Pike, Malcolm C.
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Van den Berg, Da ...
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Yuan, Jian-Min
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Hohensee, Chance ...
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Rodabough, Rebec ...
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Cancel-Tassin, G ...
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Roupret, Morgan
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Comperat, Eva
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Chen, Constance
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De Vivo, Immacul ...
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Giovannucci, Edw ...
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Hunter, David J.
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Kraft, Peter
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Lindstrom, Sara
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Carta, Angela
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Pavanello, Sofia
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Arici, Cecilia
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Mastrangelo, Giu ...
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Karagas, Margare ...
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Schned, Alan
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Armenti, Karla R ...
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Hosain, G. M. Mo ...
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Haiman, Chris A.
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Fraumeni, Joseph ...
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Chanock, Stephen ...
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Chatterjee, Nila ...
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Silverman, Debra ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Urology and Neph ...
- Articles in the publication
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Carcinogenesis
- By the university
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Umeå University
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Karolinska Institutet