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Impact of Age and G...
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Vishram, Julie K. K.
(author)
Impact of Age and Gender on the Prevalence and Prognostic Importance of the Metabolic Syndrome and Its Components in Europeans. The MORGAM Prospective Cohort Project
- Article/chapterEnglish2014
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2014-09-22
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Public Library of Science (PLoS),2014
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electronicrdacarrier
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LIBRIS-ID:oai:DiVA.org:umu-96832
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-96832URI
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https://doi.org/10.1371/journal.pone.0107294DOI
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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Errata PLoS ONE (2015) 10(5), e0128848 DOI: 10.1371/journal.pone.0128848
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Objective: To investigate the influence of age and gender on the prevalence and cardiovascular disease (CVD) risk in Europeans presenting with the Metabolic Syndrome (MetS). Methods: Using 36 cohorts from the MORGAM-Project with baseline between 1982-1997, 69094 men and women aged 19-78 years, without known CVD, were included. During 12.2 years of follow-up, 3.7%/2.1% of men/women died due to CVD. The corresponding percentages for fatal and nonfatal coronary heart disease (CHD) and stroke were 8.3/3.8 and 3.1/2.5. Results: The prevalence of MetS, according to modified definitions of the International Diabetes Federation (IDF) and the revised National Cholesterol Education Program-Adult Treatment Panel III (NCEP-ATPIII), increased across age groups for both genders (P<0.0001); with a 5-fold increase in women from ages 19-39 years to 60-78 years (7.4%/7.6% to 35.4%/37.6% for IDF/NCEP-ATPIII) and a 2-fold increase in men (5.3%/10.5% to 11.5%/21.8%). Using multivariate-adjusted Cox regressions, the associations between MetS and all three CVD events were significant (P<0.0001). For IDF/NCEP-ATPIII in men and women, hazard ratio (HR) for CHD was 1.60/1.62 and 1.93/2.03, for CVD mortality 1.73/1.65 and 1.77/2.06, and for stroke 1.51/1.53 and 1.58/1.77. Whereas in men the HRs for CVD events were independent of age (MetS*age, P>0.05), in women the HRs for CHD declined with age (HRs 3.23/3.98 to 1.55/1.56; MetS*age, P = 0.01/P = 0.001 for IDF/NCEP-ATPIII) while the HRs for stroke tended to increase (HRs 1.31/1.25 to 1.55/1.83; MetS*age, P>0.05). Conclusion: In Europeans, both age and gender influenced the prevalence of MetS and its prognostic significance. The present results emphasise the importance of being critical of MetS in its current form as a marker of CVD especially in women, and advocate for a redefinition of MetS taking into account age especially in women.
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Borglykke, Anders
(author)
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Andreasen, Anne H.
(author)
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Jeppesen, Jorgen
(author)
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Ibsen, Hans
(author)
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Jorgensen, Torben
(author)
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Palmieri, Luigi
(author)
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Giampaoli, Simona
(author)
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Donfrancesco, Chiara
(author)
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Kee, Frank
(author)
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Mancia, Giuseppe
(author)
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Cesana, Giancarlo
(author)
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Kuulasmaa, Kari
(author)
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Salomaa, Veikko
(author)
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Sans, Susana
(author)
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Ferrieres, Jean
(author)
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Dallongeville, Jean
(author)
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Söderberg, StefanUmeå universitet,Kardiologi(Swepub:umu)stso0001
(author)
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Arveiler, Dominique
(author)
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Wagner, Aline
(author)
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Tunstall-Pedoe, Hugh
(author)
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Drygas, Wojciech
(author)
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Olsen, Michael H.
(author)
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Umeå universitetKardiologi
(creator_code:org_t)
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In:PLOS ONE: Public Library of Science (PLoS)9:9, s. e107294-1932-6203
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