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High cyclin B1 expr...
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Aaltonen, Kirsimari
(author)
High cyclin B1 expression is associated with poor survival in breast cancer
- Article/chapterEnglish2009
Publisher, publication year, extent ...
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2009-03-17
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Springer Science and Business Media LLC,2009
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-105531
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-105531URI
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https://doi.org/10.1038/sj.bjc.6604874DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:118532857URI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Cyclin B1 regulates the G(2)-M transition of the cell cycle. Cyclin B1 expression is higher in premalignant and malignant than normal breast lesions. Correlation of cyclin B1 expression with other histopathological variables and prognostic role in breast cancer are not fully understood. Traditionally used prognostic criteria identify large subset of patients to receive adjuvant chemotherapy and to be exposed to adverse effects. A reliable and simple method helping prognostic evaluation in breast cancer is needed. We analysed cyclin B1 expression on 1348 invasive breast cancers and studied correlations with other histopathological variables and survival. High cyclin B1 correlated with high tumour grade, large tumour size and positive nodal status, oestrogen and progesterone receptor negativity, positive HER2 and p53 status, young age at diagnosis, and high cyclin E, cyclin A and Ki67 expression. Among patients not given adjuvant chemotherapy high cyclin B1 was a strong predictor of shorter overall and metastasis-free survival (RR 3.74, P<0.0005 and RR 3.51, P<0.0005, respectively), and remained as an independent prognostic factor also in multivariate analysis (RR 1.80, P=0.04 and RR 2.31, P=0.02, respectively). This study suggests high cyclin B1 associates with aggressive phenotype and is an independent prognostic factor in breast cancer.
Subject headings and genre
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breast cancer
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cyclin B1
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survival
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prognosis
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MEDICINE
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MEDICIN
Added entries (persons, corporate bodies, meetings, titles ...)
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Amini, Rose-MarieKarolinska Institutet,Uppsala universitet,Institutionen för immunologi, genetik och patologi(Swepub:uu)roseamin
(author)
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Heikkilä, Päivi
(author)
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Aittomäki, Kristiina
(author)
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Tamminen, A.
(author)
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Nevanlinna, Heli
(author)
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Blomqvist, CarlUppsala universitet,Enheten för onkologi
(author)
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Uppsala universitetInstitutionen för immunologi, genetik och patologi
(creator_code:org_t)
Related titles
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In:British Journal of Cancer: Springer Science and Business Media LLC100:7, s. 1055-600007-09201532-1827
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