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Analysis of the DNA...
Analysis of the DNA sequence and duplication history of human chromosome 15
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- Zody, Michael, 1968- (author)
- Broad Institute
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- Garber, Manuel (author)
- Broad Institute
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- Sharpe, Ted (author)
- Broad Institute
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- Young, Sarah (author)
- Broad Institute
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- Rowen, Lee (author)
- Institute for Systems Biology
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- O'Neill, Keith (author)
- Broad Institute
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- Whittaker, Charles (author)
- Broad Institute
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- Kamal, Michael (author)
- Broad Institute
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- Chang, Jean (author)
- Broad Institute
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- Cuomo, Christina (author)
- Broad Institute
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- Dewar, Ken (author)
- Broad Institute
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- FitzGerald, Michael (author)
- Broad Institute
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- Kodira, Chinnappa (author)
- Broad Institute
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- Madan, Anup (author)
- Institute for Systems Biology
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- Qin, Shizhen (author)
- Institute for Systems Biology
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- Yang, Xiaoping (author)
- Broad Institute
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- Abbasi, Nissa (author)
- Institute for Systems Biology
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- Abouelleil, Amr (author)
- Broad Institute
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- Arachchi, Harindra (author)
- Broad Institute
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- Baradarani, Lida (author)
- Institute for Systems Biology
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- Birditt, Brian (author)
- Institute for Systems Biology
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- Bloom, Scott (author)
- Institute for Systems Biology
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- Bloom, Toby (author)
- Broad Institute
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- Borowsky, Mark (author)
- Broad Institute
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- Burke, Jeremy (author)
- Institute for Systems Biology
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- Butler, Jonathan (author)
- Broad Institute
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- Cook, April (author)
- Broad Institute
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- DeArellano, Kurt (author)
- Broad Institute
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- DeCaprio, David (author)
- Broad Institute
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- Dorris, Lester (author)
- Broad Institute
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- Dors, Monica (author)
- Institute for Systems Biology
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- Eichler, Evan (author)
- University of Washington, Department of Genome Sciences
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- Engels, Reinhard (author)
- Broad Institute
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- Fahey, Jessica (author)
- Institute for Systems Biology
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- Fleetwood, Peter (author)
- Institute for Systems Biology
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- Friedman, Cynthia (author)
- Fred Hutchinson Cancer Research Center, Division of Human Biology
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- Gearin, Gary (author)
- Broad Institute
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- Hall, Jennifer (author)
- Broad Institute
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- Hensley, Grace (author)
- Institute for Systems Biology
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- Johnson, Ericka (author)
- Institute for Systems Biology
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- Jones, Charlien (author)
- Broad Institute
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- Kamat, Asha (author)
- Broad Institute
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- Kaur, Amardeep (author)
- Institute for Systems Biology
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- Locke, Devin (author)
- University of Washington, Department of Genome Sciences
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- Madan, Anuradha (author)
- Institute for Systems Biology
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- Munson, Glen (author)
- Broad Institute
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- Jaffe, David (author)
- Broad Institute
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- Lui, Annie (author)
- Broad Institute
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- Macdonald, Pendexter (author)
- Broad Institute
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- Mauceli, Evan (author)
- Broad Institute
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- Naylor, Jerome (author)
- Broad Institute
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- Nesbitt, Ryan (author)
- Institute for Systems Biology
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- Nicol, Robert (author)
- Broad Institute
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- O'Leary, Sinéad (author)
- Broad Institute
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- Ratcliffe, Amber (author)
- Institute for Systems Biology
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- Rounsley, Steven (author)
- Broad Institute
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- She, Xinwei (author)
- University of Washington, Department of Genome Sciences
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- Sneddon, Katherine (author)
- University College London, Department of Biology,HUGO Gene Nomenclature Committee
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- Stewart, Sandra (author)
- Institute for Systems Biology
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- Sougnez, Carrie (author)
- Broad Institute
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- Stone, Sabrina (author)
- Broad Institute
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- Topham, Kerri (author)
- Broad Institute
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- Vincent, Dascena (author)
- Institute for Systems Biology
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- Wang, Shunguang (author)
- Broad Institute
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- Zimmer, Andrew (author)
- Broad Institute
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- Birren, Bruce (author)
- Broad Institute
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- Hood, Leroy (author)
- Institute for Systems Biology
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- Lander, ic (author)
- Broad Institute
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- Nusbaum, Chad (author)
- Broad Institute
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(creator_code:org_t)
- Springer Science and Business Media LLC, 2006
- 2006
- English.
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In: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 440:7084, s. 671-675
- Related links:
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https://www.nature.c...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
Close
- Here we present a finished sequence of human chromosome 15, together with a high-quality gene catalogue. As chromosome 15 is one of seven human chromosomes with a high rate of segmental duplication, we have carried out a detailed analysis of the duplication structure of the chromosome. Segmental duplication in chromosome 15 are largely clustered in two regions, on proximal and distal 15q; the proximal region is notable because recombination among the segmental duplications can result in deletions causing Prader-Willi and Angelman syndromes. Sequence analysis shows that the proximal and distal regions of 15q share extensive ancient similarity. Using a simple approach, we have been able to reconstruct many of the events by which the current duplication structure arose. We find that most of the intrachromosomal duplications seem to share a common ancestry. Finally, we demonstrate that some remaining gaps in the genome sequence are probably due to structural polymorphisms between haplotypes; this may explain a significant fraction of the gaps remaining in the human genome.
Subject headings
- NATURVETENSKAP -- Biologi -- Genetik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Genetics (hsv//eng)
Keyword
- Genetics
- Genetik
- Genetics
- Genetik
Publication and Content Type
- ref (subject category)
- art (subject category)
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Nature
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To the university's database
- By the author/editor
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Zody, Michael, 1 ...
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Garber, Manuel
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Sharpe, Ted
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Young, Sarah
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Rowen, Lee
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O'Neill, Keith
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show more...
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Whittaker, Charl ...
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Kamal, Michael
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Chang, Jean
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Cuomo, Christina
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Dewar, Ken
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FitzGerald, Mich ...
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Kodira, Chinnapp ...
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Madan, Anup
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Qin, Shizhen
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Yang, Xiaoping
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Abbasi, Nissa
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Abouelleil, Amr
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Arachchi, Harind ...
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Baradarani, Lida
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Birditt, Brian
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Bloom, Scott
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Bloom, Toby
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Borowsky, Mark
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Burke, Jeremy
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Butler, Jonathan
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Cook, April
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DeArellano, Kurt
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DeCaprio, David
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Dorris, Lester
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Dors, Monica
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Eichler, Evan
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Engels, Reinhard
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Fahey, Jessica
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Fleetwood, Peter
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Friedman, Cynthi ...
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Gearin, Gary
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Hall, Jennifer
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Hensley, Grace
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Johnson, Ericka
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Jones, Charlien
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Kamat, Asha
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Kaur, Amardeep
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Locke, Devin
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Madan, Anuradha
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Munson, Glen
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Jaffe, David
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Lui, Annie
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Macdonald, Pende ...
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Mauceli, Evan
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Naylor, Jerome
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Nesbitt, Ryan
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Nicol, Robert
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O'Leary, Sinéad
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Ratcliffe, Amber
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Rounsley, Steven
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She, Xinwei
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Sneddon, Katheri ...
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Stewart, Sandra
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Sougnez, Carrie
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Stone, Sabrina
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Topham, Kerri
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Vincent, Dascena
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Wang, Shunguang
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Zimmer, Andrew
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Birren, Bruce
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Hood, Leroy
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Lander, ic
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Nusbaum, Chad
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Genetics
- Articles in the publication
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Nature
- By the university
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Uppsala University