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LPL is the stronges...
LPL is the strongest prognostic factor in a comparative analysis of RNA-based markers in early chronic lymphocytic leukemia
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- Kaderi, Mohd Arifin (author)
- Uppsala universitet,Hematologi och immunologi,Molecular Haematology
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- Kanduri, Meena (author)
- Uppsala universitet,Hematologi och immunologi,Molecular Haematology
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- Buhl, Anne Mette (author)
- Department of Hematology, Leukemia Laboratory, Rigshospitalet, Copenhagen, Denmark
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- Sevov, Marie (author)
- Uppsala universitet,Hematologi och immunologi,Molecular Haematology
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- Cahill, Nicola (author)
- Uppsala universitet,Hematologi och immunologi,Molecular Haematology
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- Gunnarsson, Rebeqa (author)
- Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine,Department of Laboratory Medicine, Stem Cell Center, Hematology and Transplantation, Lund University, Lund, Sweden
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- Jansson, Mattias (author)
- Uppsala universitet,Hematologi och immunologi
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- Ekström Smedby, Karin (author)
- Karolinska Institutet,Department of Medicine, Clinical Epidemiology Unit, Karolinska Institutet, Stockholm, Sweden
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- Hjalgrim, Hendrik (author)
- Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark
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- Juliusson, Gunnar (author)
- Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine,Department of Laboratory Medicine, Stem Cell Center, Hematology and Transplantation, Lund University, Lund, Sweden
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- Jurlander, Jesper (author)
- Department of Hematology, Leukemia Laboratory, Rigshospitalet, Copenhagen, Denmark
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- Mansouri, Larry (author)
- Uppsala universitet,Hematologi och immunologi,Molecular Haematology
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- Rosenquist, Richard (author)
- Uppsala universitet,Hematologi och immunologi,Molecular Haematology
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(creator_code:org_t)
- 2011-04-20
- 2011
- English.
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In: Haematologica. - : Ferrata Storti Foundation (Haematologica). - 0390-6078 .- 1592-8721. ; 96:8, s. 1153-1160
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Abstract
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- BACKGROUND:The expression levels of LPL, ZAP70, TCL1A, CLLU1 and MCL1 have recently been proposed as prognostic factors in chronic lymphocytic leukemia. However, few studies have systematically compared these different RNA-based markers.DESIGN AND METHODS:Using real-time quantitative PCR, we measured the mRNA expression levels of these genes in unsorted samples from 252 newly diagnosed chronic lymphocytic leukemia patients and correlated our data with established prognostic markers (for example Binet stage, CD38, IGHV gene mutational status and genomic aberrations) and clinical outcome.RESULTS:High expression levels of all RNA-based markers, except MCL1, predicted shorter overall survival and time to treatment, with LPL being the most significant. In multivariate analysis including the RNA-based markers, LPL expression was the only independent prognostic marker for overall survival and time to treatment. When studying LPL expression and the established markers, LPL expression retained its independent prognostic strength for overall survival. All of the RNA-based markers, albeit with varying ability, added prognostic information to established markers, with LPL expression giving the most significant results. Notably, high LPL expression predicted a worse outcome in good-prognosis subgroups, such as patients with mutated IGHV genes, Binet stage A, CD38 negativity or favorable cytogenetics. In particular, the combination of LPL expression and CD38 could further stratify Binet stage A patients.CONCLUSIONS:LPL expression is the strongest RNA-based prognostic marker in chronic lymphocytic leukemia that could potentially be applied to predict outcome in the clinical setting, particularly in the large group of patients with favorable prognosis.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Keyword
- MEDICINE
- MEDICIN
- Clinical genetics
- Klinisk genetik
- Oncology
- Onkologi
- Klinisk genetik
- Clinical Genetics
- Medicinsk genetik
- Medical Genetics
- Oncology
- Onkologi
- LPL
- RNA-based markers
- chronic lymphocytic leukemia
- prognosis
Publication and Content Type
- ref (subject category)
- art (subject category)
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Kaderi, Mohd Ari ...
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Kanduri, Meena
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Buhl, Anne Mette
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Sevov, Marie
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Cahill, Nicola
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Gunnarsson, Rebe ...
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show more...
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Jansson, Mattias
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Ekström Smedby, ...
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Hjalgrim, Hendri ...
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Juliusson, Gunna ...
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Jurlander, Jespe ...
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Mansouri, Larry
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Rosenquist, Rich ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
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MEDICAL AND HEAL ...
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and Cancer and Oncol ...
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MEDICAL AND HEAL ...
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and Hematology
- Articles in the publication
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Haematologica
- By the university
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Uppsala University
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Lund University
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Karolinska Institutet