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LPL is the stronges...
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Kaderi, Mohd ArifinUppsala universitet,Hematologi och immunologi,Molecular Haematology
(author)
LPL is the strongest prognostic factor in a comparative analysis of RNA-based markers in early chronic lymphocytic leukemia
- Article/chapterEnglish2011
Publisher, publication year, extent ...
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2011-04-20
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Ferrata Storti Foundation (Haematologica),2011
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-111078
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-111078URI
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https://doi.org/10.3324/haematol.2010.039396DOI
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https://lup.lub.lu.se/record/2186949URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:123199769URI
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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BACKGROUND:The expression levels of LPL, ZAP70, TCL1A, CLLU1 and MCL1 have recently been proposed as prognostic factors in chronic lymphocytic leukemia. However, few studies have systematically compared these different RNA-based markers.DESIGN AND METHODS:Using real-time quantitative PCR, we measured the mRNA expression levels of these genes in unsorted samples from 252 newly diagnosed chronic lymphocytic leukemia patients and correlated our data with established prognostic markers (for example Binet stage, CD38, IGHV gene mutational status and genomic aberrations) and clinical outcome.RESULTS:High expression levels of all RNA-based markers, except MCL1, predicted shorter overall survival and time to treatment, with LPL being the most significant. In multivariate analysis including the RNA-based markers, LPL expression was the only independent prognostic marker for overall survival and time to treatment. When studying LPL expression and the established markers, LPL expression retained its independent prognostic strength for overall survival. All of the RNA-based markers, albeit with varying ability, added prognostic information to established markers, with LPL expression giving the most significant results. Notably, high LPL expression predicted a worse outcome in good-prognosis subgroups, such as patients with mutated IGHV genes, Binet stage A, CD38 negativity or favorable cytogenetics. In particular, the combination of LPL expression and CD38 could further stratify Binet stage A patients.CONCLUSIONS:LPL expression is the strongest RNA-based prognostic marker in chronic lymphocytic leukemia that could potentially be applied to predict outcome in the clinical setting, particularly in the large group of patients with favorable prognosis.
Subject headings and genre
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Kanduri, MeenaUppsala universitet,Hematologi och immunologi,Molecular Haematology(Swepub:uu)meenkand
(author)
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Buhl, Anne MetteDepartment of Hematology, Leukemia Laboratory, Rigshospitalet, Copenhagen, Denmark
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Sevov, MarieUppsala universitet,Hematologi och immunologi,Molecular Haematology(Swepub:uu)masev498
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Cahill, NicolaUppsala universitet,Hematologi och immunologi,Molecular Haematology(Swepub:uu)nicca470
(author)
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Gunnarsson, RebeqaLund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine,Department of Laboratory Medicine, Stem Cell Center, Hematology and Transplantation, Lund University, Lund, Sweden(Swepub:lu)stem-rgu
(author)
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Jansson, MattiasUppsala universitet,Hematologi och immunologi(Swepub:uu)mattjans
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Ekström Smedby, KarinKarolinska Institutet,Department of Medicine, Clinical Epidemiology Unit, Karolinska Institutet, Stockholm, Sweden
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Hjalgrim, HendrikDepartment of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark
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Juliusson, GunnarLund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine,Department of Laboratory Medicine, Stem Cell Center, Hematology and Transplantation, Lund University, Lund, Sweden(Swepub:lu)stem-gju
(author)
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Jurlander, JesperDepartment of Hematology, Leukemia Laboratory, Rigshospitalet, Copenhagen, Denmark
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Mansouri, LarryUppsala universitet,Hematologi och immunologi,Molecular Haematology(Swepub:uu)maman377
(author)
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Rosenquist, RichardUppsala universitet,Hematologi och immunologi,Molecular Haematology(Swepub:uu)richrose
(author)
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Uppsala universitetHematologi och immunologi
(creator_code:org_t)
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In:Haematologica: Ferrata Storti Foundation (Haematologica)96:8, s. 1153-11600390-60781592-8721
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Kaderi, Mohd Ari ...
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Kanduri, Meena
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Buhl, Anne Mette
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Sevov, Marie
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Cahill, Nicola
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Gunnarsson, Rebe ...
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Jansson, Mattias
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Ekström Smedby, ...
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