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The Role of Genetic...
The Role of Genetic Variation Near Interferon-Kappa in Systemic Lupus Erythematosus
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Harley, Isaac T. W. (author)
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Niewold, Timothy B. (author)
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Stormont, Rebecca M. (author)
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Kaufman, Kenneth M. (author)
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Glenn, Stuart B. (author)
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Franek, Beverly S. (author)
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Kelly, Jennifer A. (author)
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Kilpatrick, Jeffrey R. (author)
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Hutchings, David (author)
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Divers, Jasmin (author)
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Bruner, Gail R. (author)
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Edberg, Jeffrey C. (author)
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McGwin, Gerald, Jr. (author)
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Petri, Michelle A. (author)
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Ramsey-Goldman, Rosalind (author)
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Reveille, John D. (author)
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Vila-Perez, Luis M. (author)
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Merrill, Joan T. (author)
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Gilkeson, Gary S. (author)
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Vyse, Timothy J. (author)
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- Alarcón-Riquelme, Marta E. (author)
- Uppsala universitet,Institutionen för genetik och patologi
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Cho, Soo-Kyung (author)
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Jacob, Chaim O. (author)
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Alarcon, Graciela S. (author)
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Moser, Kathy L. (author)
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Gaffney, Patrick M. (author)
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Kimberly, Robert P. (author)
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Bae, Sang-Cheol (author)
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Langefeld, Carl D. (author)
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Harley, John B. (author)
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Guthridge, Joel M. (author)
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James, Judith A. (author)
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(creator_code:org_t)
- Hindawi Limited, 2010
- 2010
- English.
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In: Journal of Biomedicine and Biotechnology. - : Hindawi Limited. - 1110-7243 .- 1110-7251. ; , s. 706825-
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by increased type I interferons (IFNs) and multiorgan inflammation frequently targeting the skin. IFN-kappa is a type I IFN expressed in skin. A pooled genome-wide scan implicated the IFNK locus in SLE susceptibility. We studied IFNK single nucleotide polymorphisms (SNPs) in 3982 SLE cases and 4275 controls, composed of European (EA), African-American (AA), and Asian ancestry. rs12553951C was associated with SLE in EA males (odds ratio = 1.93, P = 2.5 x 10(-4)), but not females. Suggestive associations with skin phenotypes in EA and AA females were found, and these were also sex-specific. IFNK SNPs were associated with increased serum type I IFN in EA and AA SLE patients. Our data suggest a sex-dependent association between IFNK SNPs and SLE and skin phenotypes. The serum IFN association suggests that IFNK variants could influence type I IFN producing plasmacytoid dendritic cells in affected skin.
Keyword
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Harley, Isaac T. ...
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Niewold, Timothy ...
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Stormont, Rebecc ...
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Kaufman, Kenneth ...
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Glenn, Stuart B.
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Franek, Beverly ...
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show more...
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Kelly, Jennifer ...
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Kilpatrick, Jeff ...
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Hutchings, David
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Divers, Jasmin
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Bruner, Gail R.
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Edberg, Jeffrey ...
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McGwin, Gerald, ...
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Petri, Michelle ...
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Ramsey-Goldman, ...
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Reveille, John D ...
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Vila-Perez, Luis ...
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Merrill, Joan T.
-
Gilkeson, Gary S ...
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Vyse, Timothy J.
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Alarcón-Riquelme ...
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Cho, Soo-Kyung
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Jacob, Chaim O.
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Alarcon, Graciel ...
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Moser, Kathy L.
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Gaffney, Patrick ...
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Kimberly, Robert ...
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Bae, Sang-Cheol
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Langefeld, Carl ...
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Harley, John B.
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Guthridge, Joel ...
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James, Judith A.
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show less...
- Articles in the publication
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Journal of Biome ...
- By the university
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Uppsala University