Search: onr:"swepub:oai:DiVA.org:uu-171357" >
Staging of neurofib...
Staging of neurofibrillary pathology in Alzheimer's disease : a study of the BrainNet Europe Consortium.
-
- Alafuzoff, Irina (author)
- Department of Neuroscience and Neurology, University of Kuopio Finland
-
Arzberger, Thomas (author)
-
Al-Sarraj, Safa (author)
-
show more...
-
Bodi, Istvan (author)
-
- Bogdanovic, Nenad (author)
- Karolinska Institutet
-
Braak, Heiko (author)
-
Bugiani, Orso (author)
-
Del-Tredici, Kelly (author)
-
Ferrer, Isidro (author)
-
Gelpi, Ellen (author)
-
Giaccone, Giorgio (author)
-
Graeber, Manuel B (author)
-
Ince, Paul (author)
-
Kamphorst, Wouter (author)
-
King, Andrew (author)
-
Korkolopoulou, Penelope (author)
-
Kovács, Gábor G (author)
-
Larionov, Sergey (author)
-
Meyronet, David (author)
-
Monoranu, Camelia (author)
-
Parchi, Piero (author)
-
Patsouris, Efstratios (author)
-
Roggendorf, Wolfgang (author)
-
Seilhean, Danielle (author)
-
Tagliavini, Fabrizio (author)
-
Stadelmann, Christine (author)
-
Streichenberger, Nathalie (author)
-
Thal, Dietmar R (author)
-
Wharton, Stephen B (author)
-
Kretzschmar, Hans (author)
-
show less...
-
(creator_code:org_t)
- 2008-03-27
- 2008
- English.
-
In: Brain Pathology. - : Wiley. - 1015-6305 .- 1750-3639. ; 18:4, s. 484-96
- Related links:
-
https://onlinelibrar...
-
show more...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
http://kipublication...
-
show less...
Abstract
Subject headings
Close
- It has been recognized that molecular classifications will form the basis for neuropathological diagnostic work in the future. Consequently, in order to reach a diagnosis of Alzheimer's disease (AD), the presence of hyperphosphorylated tau (HP-tau) and beta-amyloid protein in brain tissue must be unequivocal. In addition, the stepwise progression of pathology needs to be assessed. This paper deals exclusively with the regional assessment of AD-related HP-tau pathology. The objective was to provide straightforward instructions to aid in the assessment of AD-related immunohistochemically (IHC) detected HP-tau pathology and to test the concordance of assessments made by 25 independent evaluators. The assessment of progression in 7-microm-thick sections was based on assessment of IHC labeled HP-tau immunoreactive neuropil threads (NTs). Our results indicate that good agreement can be reached when the lesions are substantial, i.e., the lesions have reached isocortical structures (stage V-VI absolute agreement 91%), whereas when only mild subtle lesions were present the agreement was poorer (I-II absolute agreement 50%). Thus, in a research setting when the extent of lesions is mild, it is strongly recommended that the assessment of lesions should be carried out by at least two independent observers.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Klinisk laboratoriemedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Clinical Laboratory Medicine (hsv//eng)
Keyword
- Pathology
- Patologi
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Alafuzoff, Irina
-
Arzberger, Thoma ...
-
Al-Sarraj, Safa
-
Bodi, Istvan
-
Bogdanovic, Nena ...
-
Braak, Heiko
-
show more...
-
Bugiani, Orso
-
Del-Tredici, Kel ...
-
Ferrer, Isidro
-
Gelpi, Ellen
-
Giaccone, Giorgi ...
-
Graeber, Manuel ...
-
Ince, Paul
-
Kamphorst, Woute ...
-
King, Andrew
-
Korkolopoulou, P ...
-
Kovács, Gábor G
-
Larionov, Sergey
-
Meyronet, David
-
Monoranu, Cameli ...
-
Parchi, Piero
-
Patsouris, Efstr ...
-
Roggendorf, Wolf ...
-
Seilhean, Daniel ...
-
Tagliavini, Fabr ...
-
Stadelmann, Chri ...
-
Streichenberger, ...
-
Thal, Dietmar R
-
Wharton, Stephen ...
-
Kretzschmar, Han ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Clinical Laborat ...
- Articles in the publication
-
Brain Pathology
- By the university
-
Uppsala University
-
Karolinska Institutet