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Baseline NT-proBNP ...
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van Diepen, Sean
(author)
Baseline NT-proBNP and biomarkers of inflammation and necrosis in patients with ST-segment elevation myocardial infarction : insights from the APEX-AMI trial
- Article/chapterEnglish2012
Publisher, publication year, extent ...
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2012-02-04
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Springer Science and Business Media LLC,2012
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-177573
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-177573URI
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https://doi.org/10.1007/s11239-012-0691-0DOI
Supplementary language notes
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Language:English
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Summary in:English
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Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Coronary plaque rupture is associated with a systemic inflammatory response. The relationship between baseline N-terminal pro B-type natriuretic peptide (NT-proBNP), a prognostic marker in patients with acute coronary syndromes, and systemic inflammatory mediators in patients with ST-segment elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (PCI) is not well described. Of 5,745 STEMI patients treated with primary PCI in the APEX-AMI trial, we evaluated the relationship between baseline NT-proBNP levels and baseline levels of inflammatory markers and markers of myonecrosis in a subset of 772 who were enrolled in a biomarker substudy. Spearman correlations (r (s)) were calculated between baseline NT-proBNP levels and a panel of ten systemic inflammatory biomarkers. Interleukin (IL)-6, a pro-inflammatory cytokine, was significantly positively correlated with NT-proBNP (r (s) = 0.317, P < 0.001). In a sensitivity analysis excluding all heart failure patients, the correlation between baseline IL-6 and NT-proBNP remained significant (n = 651, r (s) = 0.296, P < 0.001). A positive association was also observed with high sensitivity C-reactive protein (r (s) = 0.377, P < 0.001) and there was a weak negative correlation with the anti-inflammatory cytokine IL-10 (r (s) = -0.109, P = 0.003). No other significant correlations were observed among the other testes inflammatory cytokines and chemokines. In STEMI patients undergoing primary PCI, the pro-inflammatory cytokine IL-6 was modestly correlated with baseline NT-proBNP levels. This relationship remained significant in patients without heart failure. This finding is consistent with pre-clinical and clinical research suggesting that systemic inflammation may influence NT-proBNP expression independently of myocardial stretch.
Subject headings and genre
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N-terminal pro-brain natriuretic peptide
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Interleukin-6
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Interleukin-10
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C-reactive protein
Added entries (persons, corporate bodies, meetings, titles ...)
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Roe, Matthew T.
(author)
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Lopes, Renato D.
(author)
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Stebbins, Amanda
(author)
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James, StefanUppsala universitet,Uppsala kliniska forskningscentrum (UCR),kardiologi(Swepub:uu)stjam367
(author)
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Newby, L. Kristin
(author)
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Moliterno, David J.
(author)
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Neumann, Franz-Josef
(author)
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Ezekowitz, Justin A.
(author)
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Mahaffey, Kenneth W.
(author)
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Hochman, Judith S.
(author)
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Hamm, Christian W.
(author)
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Armstrong, Paul W.
(author)
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Theroux, Pierre
(author)
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Granger, Christopher B.
(author)
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Uppsala universitetUppsala kliniska forskningscentrum (UCR)
(creator_code:org_t)
Related titles
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In:Journal of Thrombosis and Thrombolysis: Springer Science and Business Media LLC34:1, s. 106-1130929-53051573-742X
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van Diepen, Sean
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Roe, Matthew T.
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Lopes, Renato D.
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Stebbins, Amanda
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James, Stefan
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Newby, L. Kristi ...
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Moliterno, David ...
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Neumann, Franz-J ...
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Ezekowitz, Justi ...
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Mahaffey, Kennet ...
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Hochman, Judith ...
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Hamm, Christian ...
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Armstrong, Paul ...
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Theroux, Pierre
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Granger, Christo ...
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Uppsala University