Identification of Candidate Serum Proteins for Classifying Well-Differentiated Small Intestinal Neuroendocrine Tumors

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Darmanis, SpyrosUppsala universitet,Molekylära verktyg,Science for Life Laboratory, SciLifeLab (author)

Identification of Candidate Serum Proteins for Classifying Well-Differentiated Small Intestinal Neuroendocrine Tumors

Article/chapterEnglish2013

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2013-11-25
Public Library of Science (PLoS),2013
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LIBRIS-ID:oai:DiVA.org:uu-205549
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-205549URI
https://doi.org/10.1371/journal.pone.0081712DOI
https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-139205URI

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Language:English
Summary in:English

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QC 20140113
BackgroundPatients with well-differentiated small intestine neuroendocrine tumors (WD-SI-NET) are most often diagnosed at a metastatic stage of disease, which reduces possibilities for a curative treatment. Thus new approaches for earlier detection and improved monitoring of the disease are required.Materials and methodsSuspension bead arrays targeting 124 unique proteins with antibodies from the Human Protein Atlas were used to profile biotinylated serum samples. Discoveries from a cohort of 77 individuals were followed up in a cohort of 132 individuals both including healthy controls as well as patients with untreated primary WD-SI-NETs, lymph node metastases and liver metastases.Results A set of 20 antibodies suggested promising proteins for further verification based on technically verified statistical significance. Proceeding, we assessed the classification performance in an independent cohort of patient serum, achieving, classification accuracy of up to 85% with different subsets of antibodies in respective pairwise group comparisons. The protein profiles of nine targets, namely IGFBP2, IGF1, SHKBP1, ETS1, IL1α, STX2, MAML3, EGR3 and XIAP were verified as significant contributors to tumor classification.ConclusionsWe propose new potential protein biomarker candidates for classifying WD-SI-NET at different stage of disease. Further evaluation of these proteins in larger sample sets and with alternative approaches is needed in order to further improve our understanding of their functional relation to WD-SI-NET and their eventual use in diagnostics.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Medicinsk bioteknologi Medicinsk bioteknologi hsv//swe
MEDICAL AND HEALTH SCIENCES Medical Biotechnology Medical Biotechnology hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Cell- och molekylärbiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Cell and Molecular Biology hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Cancer och onkologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Cancer and Oncology hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Endokrinologi och diabetes hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Endocrinology and Diabetes hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Gastroenterologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Gastroenterology and Hepatology hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Medicinsk bioteknologi hsv//swe
MEDICAL AND HEALTH SCIENCES Medical Biotechnology hsv//eng
Endokrinologi och Diabetologi
Endocrinology and Diabetology
Molecular Biology
Molekylärbiologi
Molekylär bioteknik
Molecular Biotechnology
Oncology
Onkologi
Growth-Factor

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Cui, TaoUppsala universitet,Onkologisk endokrinologi(Swepub:uu)taocu332 (author)
Drobin, KimiKTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab,KTH - Royal Institute of Technology, Stockholm, Sweden,Science for Life Laboratory, School of Biotechnology(Swepub:kth)u130lrx0 (author)
Li, Su-ChenUppsala universitet,Onkologisk endokrinologi(Swepub:uu)suali171 (author)
Öberg, KjellUppsala universitet,Onkologisk endokrinologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)kjellob (author)
Nilsson, PeterKTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab,KTH - Royal Institute of Technology, Stockholm, Sweden,Science for Life Laboratory, School of Biotechnology(Swepub:kth)u1ws88sk (author)
Schwenk, Jochen M.KTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab,KTH - Royal Institute of Technology, Stockholm, Sweden,Science for Life Laboratory, School of Biotechnology(Swepub:kth)u1h7wtme (author)
Giandomenico, ValeriaUppsala universitet,Onkologisk endokrinologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)valegian (author)
Uppsala universitetMolekylära verktyg (creator_code:org_t)

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In:PLOS ONE: Public Library of Science (PLoS)8:11, s. e81712-1932-6203

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