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Genome-wide association analysis identifies six new loci associated with forced vital capacity

Loth, Daan W (author)
Artigas, María Soler (author)
Gharib, Sina A (author)
show more...
Wain, Louise V (author)
Franceschini, Nora (author)
Koch, Beate (author)
Pottinger, Tess D (author)
Smith, Albert Vernon (author)
Duan, Qing (author)
Oldmeadow, Chris (author)
Lee, Mi Kyeong (author)
Strachan, David P (author)
James, Alan L (author)
Huffman, Jennifer E (author)
Vitart, Veronique (author)
Ramasamy, Adaikalavan (author)
Wareham, Nicholas J (author)
Kaprio, Jaakko (author)
Wang, Xin-Qun (author)
Trochet, Holly (author)
Kähönen, Mika (author)
Flexeder, Claudia (author)
Albrecht, Eva (author)
Lopez, Lorna M (author)
de Jong, Kim (author)
Thyagarajan, Bharat (author)
Alves, Alexessander Couto (author)
Enroth, Stefan (author)
Uppsala universitet,Institutionen för immunologi, genetik och patologi,Science for Life Laboratory, SciLifeLab,Gyllensten
Omenaas, Ernst (author)
Joshi, Peter K (author)
Fall, Tove (author)
Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab
Viñuela, Ana (author)
Launer, Lenore J (author)
Loehr, Laura R (author)
Fornage, Myriam (author)
Li, Guo (author)
Wilk, Jemma B (author)
Tang, Wenbo (author)
Manichaikul, Ani (author)
Lahousse, Lies (author)
Harris, Tamara B (author)
North, Kari E (author)
Rudnicka, Alicja R (author)
Hui, Jennie (author)
Gu, Xiangjun (author)
Lumley, Thomas (author)
Wright, Alan F (author)
Hastie, Nicholas D (author)
Campbell, Susan (author)
Kumar, Rajesh (author)
Pin, Isabelle (author)
Scott, Robert A (author)
Pietiläinen, Kirsi H (author)
Surakka, Ida (author)
Liu, Yongmei (author)
Holliday, Elizabeth G (author)
Schulz, Holger (author)
Heinrich, Joachim (author)
Davies, Gail (author)
Vonk, Judith M (author)
Wojczynski, Mary (author)
Pouta, Anneli (author)
Johansson, Åsa (author)
Uppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för immunologi, genetik och patologi,Uppsala kliniska forskningscentrum (UCR)
Wild, Sarah H (author)
Ingelsson, Erik (author)
Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab
Rivadeneira, Fernando (author)
Völzke, Henry (author)
Hysi, Pirro G (author)
Eiriksdottir, Gudny (author)
Morrison, Alanna C (author)
Rotter, Jerome I (author)
Gao, Wei (author)
Postma, Dirkje S (author)
White, Wendy B (author)
Rich, Stephen S (author)
Hofman, Albert (author)
Aspelund, Thor (author)
Couper, David (author)
Smith, Lewis J (author)
Psaty, Bruce M (author)
Lohman, Kurt (author)
Burchard, Esteban G (author)
Uitterlinden, André G (author)
Garcia, Melissa (author)
Joubert, Bonnie R (author)
McArdle, Wendy L (author)
Musk, A Bill (author)
Hansel, Nadia (author)
Heckbert, Susan R (author)
Zgaga, Lina (author)
van Meurs, Joyce B J (author)
Navarro, Pau (author)
Rudan, Igor (author)
Oh, Yeon-Mok (author)
Redline, Susan (author)
Jarvis, Deborah L (author)
Zhao, Jing Hua (author)
Rantanen, Taina (author)
O'Connor, George T (author)
Ripatti, Samuli (author)
Scott, Rodney J (author)
Karrasch, Stefan (author)
Grallert, Harald (author)
Gaddis, Nathan C (author)
Starr, John M (author)
Wijmenga, Cisca (author)
Minster, Ryan L (author)
Lederer, David J (author)
Pekkanen, Juha (author)
Gyllensten, Ulf (author)
Uppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för immunologi, genetik och patologi
Campbell, Harry (author)
Morris, Andrew P (author)
Gläser, Sven (author)
Hammond, Christopher J (author)
Burkart, Kristin M (author)
Beilby, John (author)
Kritchevsky, Stephen B (author)
Gudnason, Vilmundur (author)
Hancock, Dana B (author)
Williams, O Dale (author)
Polasek, Ozren (author)
Zemunik, Tatijana (author)
Kolcic, Ivana (author)
Petrini, Marcy F (author)
Wjst, Matthias (author)
Kim, Woo Jin (author)
Porteous, David J (author)
Scotland, Generation (author)
Smith, Blair H (author)
Viljanen, Anne (author)
Heliövaara, Markku (author)
Attia, John R (author)
Sayers, Ian (author)
Hampel, Regina (author)
Gieger, Christian (author)
Deary, Ian J (author)
Boezen, H Marike (author)
Newman, Anne (author)
Jarvelin, Marjo-Riitta (author)
Wilson, James F (author)
Lind, Lars (author)
Uppsala universitet,Kardiovaskulär epidemiologi
Stricker, Bruno H (author)
Teumer, Alexander (author)
Spector, Timothy D (author)
Melén, Erik (author)
Karolinska Institutet
Peters, Marjolein J (author)
Lange, Leslie A (author)
Barr, R Graham (author)
Bracke, Ken R (author)
Verhamme, Fien M (author)
Sung, Joohon (author)
Hiemstra, Pieter S (author)
Cassano, Patricia A (author)
Sood, Akshay (author)
Hayward, Caroline (author)
Dupuis, Josée (author)
Hall, Ian P (author)
Brusselle, Guy G (author)
Tobin, Martin D (author)
London, Stephanie J (author)
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 (creator_code:org_t)
2014-06-15
2014
English.
In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 46, s. 669-677
  • Journal article (peer-reviewed)
Abstract Subject headings
Close  
  • Forced vital capacity (FVC), a spirometric measure of pulmonary function, reflects lung volume and is used to diagnose and monitor lung diseases. We performed genome-wide association study meta-analysis of FVC in 52,253 individuals from 26 studies and followed up the top associations in 32,917 additional individuals of European ancestry. We found six new regions associated at genome-wide significance (P < 5 × 10(-8)) with FVC in or near EFEMP1, BMP6, MIR129-2-HSD17B12, PRDM11, WWOX and KCNJ2. Two loci previously associated with spirometric measures (GSTCD and PTCH1) were related to FVC. Newly implicated regions were followed up in samples from African-American, Korean, Chinese and Hispanic individuals. We detected transcripts for all six newly implicated genes in human lung tissue. The new loci may inform mechanisms involved in lung development and the pathogenesis of restrictive lung disease.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Medical Genetics (hsv//eng)

Publication and Content Type

ref (subject category)
art (subject category)

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By the author/editor
Loth, Daan W
Artigas, María S ...
Gharib, Sina A
Wain, Louise V
Franceschini, No ...
Koch, Beate
show more...
Pottinger, Tess ...
Smith, Albert Ve ...
Duan, Qing
Oldmeadow, Chris
Lee, Mi Kyeong
Strachan, David ...
James, Alan L
Huffman, Jennife ...
Vitart, Veroniqu ...
Ramasamy, Adaika ...
Wareham, Nichola ...
Kaprio, Jaakko
Wang, Xin-Qun
Trochet, Holly
Kähönen, Mika
Flexeder, Claudi ...
Albrecht, Eva
Lopez, Lorna M
de Jong, Kim
Thyagarajan, Bha ...
Alves, Alexessan ...
Enroth, Stefan
Omenaas, Ernst
Joshi, Peter K
Fall, Tove
Viñuela, Ana
Launer, Lenore J
Loehr, Laura R
Fornage, Myriam
Li, Guo
Wilk, Jemma B
Tang, Wenbo
Manichaikul, Ani
Lahousse, Lies
Harris, Tamara B
North, Kari E
Rudnicka, Alicja ...
Hui, Jennie
Gu, Xiangjun
Lumley, Thomas
Wright, Alan F
Hastie, Nicholas ...
Campbell, Susan
Kumar, Rajesh
Pin, Isabelle
Scott, Robert A
Pietiläinen, Kir ...
Surakka, Ida
Liu, Yongmei
Holliday, Elizab ...
Schulz, Holger
Heinrich, Joachi ...
Davies, Gail
Vonk, Judith M
Wojczynski, Mary
Pouta, Anneli
Johansson, Åsa
Wild, Sarah H
Ingelsson, Erik
Rivadeneira, Fer ...
Völzke, Henry
Hysi, Pirro G
Eiriksdottir, Gu ...
Morrison, Alanna ...
Rotter, Jerome I
Gao, Wei
Postma, Dirkje S
White, Wendy B
Rich, Stephen S
Hofman, Albert
Aspelund, Thor
Couper, David
Smith, Lewis J
Psaty, Bruce M
Lohman, Kurt
Burchard, Esteba ...
Uitterlinden, An ...
Garcia, Melissa
Joubert, Bonnie ...
McArdle, Wendy L
Musk, A Bill
Hansel, Nadia
Heckbert, Susan ...
Zgaga, Lina
van Meurs, Joyce ...
Navarro, Pau
Rudan, Igor
Oh, Yeon-Mok
Redline, Susan
Jarvis, Deborah ...
Zhao, Jing Hua
Rantanen, Taina
O'Connor, George ...
Ripatti, Samuli
Scott, Rodney J
Karrasch, Stefan
Grallert, Harald
Gaddis, Nathan C
Starr, John M
Wijmenga, Cisca
Minster, Ryan L
Lederer, David J
Pekkanen, Juha
Gyllensten, Ulf
Campbell, Harry
Morris, Andrew P
Gläser, Sven
Hammond, Christo ...
Burkart, Kristin ...
Beilby, John
Kritchevsky, Ste ...
Gudnason, Vilmun ...
Hancock, Dana B
Williams, O Dale
Polasek, Ozren
Zemunik, Tatijan ...
Kolcic, Ivana
Petrini, Marcy F
Wjst, Matthias
Kim, Woo Jin
Porteous, David ...
Scotland, Genera ...
Smith, Blair H
Viljanen, Anne
Heliövaara, Mark ...
Attia, John R
Sayers, Ian
Hampel, Regina
Gieger, Christia ...
Deary, Ian J
Boezen, H Marike
Newman, Anne
Jarvelin, Marjo- ...
Wilson, James F
Lind, Lars
Stricker, Bruno ...
Teumer, Alexande ...
Spector, Timothy ...
Melén, Erik
Peters, Marjolei ...
Lange, Leslie A
Barr, R Graham
Bracke, Ken R
Verhamme, Fien M
Sung, Joohon
Hiemstra, Pieter ...
Cassano, Patrici ...
Sood, Akshay
Hayward, Carolin ...
Dupuis, Josée
Hall, Ian P
Brusselle, Guy G
Tobin, Martin D
London, Stephani ...
show less...
About the subject
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Basic Medicine
and Medical Genetics
Articles in the publication
Nature Genetics
By the university
Uppsala University
Karolinska Institutet

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