Search: onr:"swepub:oai:DiVA.org:uu-260945" >
Prelabor cesarean d...
Prelabor cesarean delivery and early-onset acute childhood leukemia risk.
-
- Thomopoulos, Thomas P (author)
- Department of Hygiene, Epidemiology and Medical Statistics, School of Medicine
-
- Skalkidou, Alkistis, 1977- (author)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa,Reproduktiv hälsa/Sundström Poromaa
-
- Dessypris, Nick (author)
- Department of Hygiene, Epidemiology and Medical Statistics, School of Medicine
-
show more...
-
- Chrousos, George (author)
- First Department of Pediatrics, ‘Aghia Sophia’ Children’s Hospital, School of Medicine, University of Athens
-
- Karalexi, Maria A (author)
- Department of Hygiene, Epidemiology and Medical Statistics, School of Medicine
-
- Karavasilis, Theodoros G (author)
- Department of Hygiene, Epidemiology and Medical Statistics, School of Medicine
-
- Baka, Margarita (author)
- Department of Pediatric HematologyOncology, ‘Pan. & Agl. Kyriakou’ Children’s Hospital
-
- Hatzipantelis, Emmanuel (author)
- Second Department of Pediatrics, AHEPA General Hospital, Aristotelion University of Thessalonik
-
- Kourti, Maria (author)
- Department of Pediatric Hematology and Oncology, Hippokration Hospital, Thessalonik
-
- Polychronopoulou, Sophia (author)
- Department of Pediatric Haematology-Oncology, ‘Aghia Sophia’ Children’s Hospital
-
- Sidi, Vasiliki (author)
- Department of Pediatric Hematology and Oncology, Hippokration Hospital, Thessaloniki
-
- Stiakaki, Eftichia (author)
- Department of Pediatric HematologyOncology, University Hospital of Heraklion, Greece
-
- Moschovi, Maria (author)
- HaematologyOncology Unit, First Department of Pediatrics, Athens University Medical School, ‘Aghia Sophia’ Children’s Hospital
-
- Loutradis, Dimitrios (author)
- First Department of Obstetrics and Gynecology, ‘Alexandra’ Hospital, School of Medicine, University of Athens
-
- Petridou, Eleni Th (author)
- Department of Hygiene, Epidemiology and Medical Statistics, School of Medicine
-
show less...
-
(creator_code:org_t)
- 2016
- 2016
- English.
-
In: European Journal of Cancer Prevention. - 0959-8278 .- 1473-5709. ; 25:2, s. 155-161
- Related links:
-
https://urn.kb.se/re...
-
show more...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- The long-term impact of cesarean delivery (CD) on the health of the offspring is being explored methodically. We sought to investigate the effect of birth by (a) prelabor and (b) during-labor CD on the risk of early-onset (≤3 years) acute lymphoblastic leukemia (ALL), specifically of its prevailing precursor B (B-ALL) subtype. A total of 1099 incident cases of ALL (957 B-ALL), 131 of acute myeloid leukemia (AML), and their 1 : 1 age-matched and sex-matched controls, derived from the Nationwide Registry for Childhood Hematological Malignancies (1996-2013), were analyzed using multivariate regression models. A null association was found between prelabor and/or during labor CD and either ALL (B-ALL) or AML in the 0-14 age range. By contrast, birth by CD increased significantly the risk of early-onset ALL [odds ratioCD (ORCD)=1.57, 95% confidence interval (CI): 1.10-2.24] mainly on account of prelabor CD (ORprelaborCD=1.66, 95% CI: 1.13-2.43). The respective figures were even higher for the early-onset precursor B-ALL (ORCD=1.66, 95% CI: 1.15-2.40 and ORprelaborCD=1.79, 95% CI: 1.21-2.66), whereas no association emerged for early-onset AML. Prelabor CD, which deprives exposure of the fetus/infant to the presumably beneficial effect of stress hormones released in both vaginal labor and during labor CD, was associated exclusively with an increased risk of early-onset ALL, particularly the precursor B-ALL subtype. If confirmed, these adverse long-term outcomes of CD may point to re-evaluation of prelabor CD practices and prompt scientific discussion on the best ways to simulate the effects of vaginal delivery, such as a precesarean induction of labor.
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Thomopoulos, Tho ...
-
Skalkidou, Alkis ...
-
Dessypris, Nick
-
Chrousos, George
-
Karalexi, Maria ...
-
Karavasilis, The ...
-
show more...
-
Baka, Margarita
-
Hatzipantelis, E ...
-
Kourti, Maria
-
Polychronopoulou ...
-
Sidi, Vasiliki
-
Stiakaki, Eftich ...
-
Moschovi, Maria
-
Loutradis, Dimit ...
-
Petridou, Eleni ...
-
show less...
- Articles in the publication
-
European Journal ...
- By the university
-
Uppsala University