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A Multi-Breed Genom...
A Multi-Breed Genome-Wide Association Analysis for Canine Hypothyroidism Identifies a Shared Major Risk Locus on CFA12
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- Bianchi, Matteo (author)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Uppsala University
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Dahlgren, Stina (author)
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Massey, Jonathan (author)
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Dietschi, Elisabeth (author)
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- Kierczak, Marcin (author)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
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Lund-Ziener, Martine (author)
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- Sundberg, Katarina (author)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för husdjursgenetik (HGEN),Department of Animal Breeding and Genetics
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Thoresen, Stein Istre (author)
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- Kampe, Olle (author)
- Karolinska Institutet
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- Andersson, Göran (author)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för husdjursgenetik (HGEN),Department of Animal Breeding and Genetics
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Ollier, William E. R. (author)
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- Hedhammar, Åke (author)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för kliniska vetenskaper (KV),Department of Clinical Sciences
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Leeb, Tosso (author)
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Lindblad-Toh, Kerstin (author)
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Kennedy, Lorna J. (author)
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Lingaas, Frode (author)
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- Pielberg, Gerli Rosengren (author)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
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(creator_code:org_t)
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- 2015-08-11
- 2015
- English.
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In: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 10:8
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Abstract
Subject headings
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- Hypothyroidism is a complex clinical condition found in both humans and dogs, thought to be caused by a combination of genetic and environmental factors. In this study we present a multi-breed analysis of predisposing genetic risk factors for hypothyroidism in dogs using three high-risk breeds-the Gordon Setter, Hovawart and the Rhodesian Ridgeback. Using a genome-wide association approach and meta-analysis, we identified a major hypothyroidism risk locus shared by these breeds on chromosome 12 (p = 2.1x10(-11)). Further characterisation of the candidate region revealed a shared similar to 167 kb risk haplotype (4,915,018-5,081,823 bp), tagged by two SNPs in almost complete linkage disequilibrium. This breed-shared risk haplotype includes three genes (LHFPL5, SRPK1 and SLC26A8) and does not extend to the dog leukocyte antigen (DLA) class II gene cluster located in the vicinity. These three genes have not been identified as candidate genes for hypothyroid disease previously, but have functions that could potentially contribute to the development of the disease. Our results implicate the potential involvement of novel genes and pathways for the development of canine hypothyroidism, raising new possibilities for screening, breeding programmes and treatments in dogs. This study may also contribute to our understanding of the genetic etiology of human hypothyroid disease, which is one of the most common endocrine disorders in humans.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
- LANTBRUKSVETENSKAPER -- Bioteknologi med applikationer på växter och djur -- Genetik och förädling inom lantbruksvetenskap (hsv//swe)
- AGRICULTURAL SCIENCES -- Agricultural Biotechnology -- Genetics and Breeding in Agricultural Sciences (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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PLOS ONE
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- By the author/editor
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Bianchi, Matteo
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Dahlgren, Stina
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Massey, Jonathan
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Dietschi, Elisab ...
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Kierczak, Marcin
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Lund-Ziener, Mar ...
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show more...
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Sundberg, Katari ...
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Thoresen, Stein ...
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Kampe, Olle
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Andersson, Göran
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Ollier, William ...
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Hedhammar, Åke
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Leeb, Tosso
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Lindblad-Toh, Ke ...
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Kennedy, Lorna J ...
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Lingaas, Frode
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Pielberg, Gerli ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
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- AGRICULTURAL SCIENCES
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AGRICULTURAL SCI ...
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and Agricultural Bio ...
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and Genetics and Bre ...
- Articles in the publication
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PLOS ONE
- By the university
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Uppsala University
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Karolinska Institutet
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Swedish University of Agricultural Sciences