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Caesarean delivery and risk of childhood leukaemia : a pooled analysis from the Childhood Leukemia International Consortium (CLIC)

Marcotte, Erin L. (författare)
Univ Minnesota, Dept Pediat, Minneapolis, MN 55455 USA.
Thomopoulos, Thomas P. (författare)
Univ Athens, Sch Med, Dept Hyg Epidemiol & Med Stat, Athens 11528, Greece.
Infante-Rivard, Claire (författare)
McGill Univ, Fac Med, Dept Epidemiol Biostat & Occupat Hlth, Montreal, PQ, Canada.
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Clavel, Jacqueline (författare)
Epidemiol & Biostat Sorbonne Paris Cite Ctr, Epidemiol Childhood & Adolescent Canc Team, INSERM, U1153, Villejuif, France.;Paris Descartes Univ, Epidemiol & Biostat Sorbonne Paris Cite Ctr, UMRS 1153, Paris, France.
Petridou, Eleni Th (författare)
Univ Athens, Sch Med, Dept Hyg Epidemiol & Med Stat, Athens 11528, Greece.
Schuz, Joachim (författare)
Int Agcy Res Canc, Sect Environm & Radiat, 150 Cours Albert Thomas, F-69372 Lyon, France.
Ezzat, Sameera (författare)
Menoufia Univ, Natl Liver Inst, Menoufia, Egypt.
Dockerty, John D. (författare)
Univ Otago, Dunedin Sch Med, Deans Dept, Dunedin, New Zealand.;Univ Otago, Dunedin Sch Med, Dept Prevent & Social Med, Dunedin, New Zealand.
Metayer, Catherine (författare)
Univ Calif Berkeley, Sch Publ Hlth, Berkeley, CA 94720 USA.
Magnani, Corrado (författare)
Univ Piemonte Orientale, SCDU Epidemiol Tumori, Dipartimento Med Traslaz, Novara, Italy.
Scheurer, Michael E. (författare)
Baylor Coll Med, Dept Pediat, Sect Hematol Oncol, Houston, TX 77030 USA.;Texas Childrens Canc Ctr, Houston, TX USA.
Mueller, Beth A. (författare)
Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA.;Univ Washington, Sch Publ Hlth, Dept Epidemiol, Seattle, WA 98195 USA.
Mora, Ana M. (författare)
Univ Nacl, Cent Amer Inst Studies Tox Subst, Heredia, Costa Rica.;Boston Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA USA.
Wesseling, Catharina (författare)
Univ Nacl, Cent Amer Inst Studies Tox Subst, Heredia, Costa Rica.
Skalkidou, Alkistis (författare)
Uppsala universitet,Obstetrik & gynekologi
Rashed, Wafaa M. (författare)
Childrens Canc Hosp Egypt 57357, Res Dept, Cairo, Egypt.
Francis, Stephen S. (författare)
Univ Calif Berkeley, Sch Publ Hlth, Berkeley, CA 94720 USA.;Univ Calif San Francisco, Neuro & Mol Epidemiol Lab, San Francisco, CA 94143 USA.
Ajrouche, Roula (författare)
Epidemiol & Biostat Sorbonne Paris Cite Ctr, Epidemiol Childhood & Adolescent Canc Team, INSERM, U1153, Villejuif, France.;Paris Descartes Univ, Epidemiol & Biostat Sorbonne Paris Cite Ctr, UMRS 1153, Paris, France.
Erdmann, Friederike (författare)
Int Agcy Res Canc, Sect Environm & Radiat, 150 Cours Albert Thomas, F-69372 Lyon, France.
Orsi, Laurent (författare)
Epidemiol & Biostat Sorbonne Paris Cite Ctr, Epidemiol Childhood & Adolescent Canc Team, INSERM, U1153, Villejuif, France.;Paris Descartes Univ, Epidemiol & Biostat Sorbonne Paris Cite Ctr, UMRS 1153, Paris, France.
Spector, Logan G. (författare)
Univ Minnesota, Dept Pediat, Minneapolis, MN 55455 USA.
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Univ Minnesota, Dept Pediat, Minneapolis, MN 55455 USA Univ Athens, Sch Med, Dept Hyg Epidemiol & Med Stat, Athens 11528, Greece. (creator_code:org_t)
2016
2016
Engelska.
Ingår i: The Lancet Haematology. - 2352-3026. ; 3:4, s. E176-E185
Relaterad länk:
https://urn.kb.se/re...
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https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Background Results from case-control studies have shown an increased risk of acute lymphoblastic leukaemia (ALL) in young children born by caesarean delivery, and prelabour caesarean delivery in particular; however, an association of method of delivery with childhood leukaemia subtypes has yet to be established. We therefore did a pooled analysis of data to investigate the association between childhood leukaemia and caesarean delivery. Methods We pooled data from 13 case-control studies from the Childhood Leukemia International Consortium done in nine countries (Canada, Costa Rica, Egypt, France, Germany, Greece, Italy, New Zealand, and the USA) for births from 1970-2013. We analysed caesarean delivery overall and by indications that probably resulted in prelabour caesarean delivery or emergency caesarean delivery. We used multivariable logistic regression models, adjusted for child's birthweight, sex, age, ethnic origin, parental education, maternal age, and study, to estimate odds ratios (ORs) and 95% CIs for the risk of ALL and acute myeloid leukaemia (AML) in children aged 0-14 years at diagnosis. Findings The studies provided data for 8780 ALL cases, 1332 AML cases, and 23 459 controls, of which the birth delivery method was known for 8655 (99%) ALL cases, 1292 (97%) AML cases, and 23 351 (> 99%) controls. Indications for caesarean delivery were available in four studies (there were caesarean deliveries for 1061 of 4313 ALL cases, 138 of 664 AML cases, and 1401 of 5884 controls). The OR for all indications of caesarean delivery and ALL was 1.06 (95% CI 0.99-1.13), and was significant for prelabour caesarean delivery and ALL (1.23 [1.04-1.47]; p= 0.018). Emergency caesarean delivery was not associated with ALL (OR 1.02 [95% CI 0.81-1.30]). AML was not associated with caesarean delivery (all indications OR 0.99 [95% CI 0.84-1.17]; prelabour caesarean delivery 0.83 [0.54-1.26]; and emergency caesarean delivery 1.05 [0.63-1.77]). Interpretation Our results suggest an increased risk of childhood ALL after prelabour caesarean delivery. If this association is causal, maladaptive immune activation due to an absence of stress response before birth in children born by prelabour caesarean delivery could be considered as a potential mechanism.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Hematologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Hematology (hsv//eng)

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