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Genome-wide associa...
Genome-wide association study identifies multiple susceptibility loci for multiple myeloma
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- Mitchell, Jonathan S. (author)
- Inst Canc Res, Div Genet & Epidemiol, 15 Cotswold Rd, Sutton SM2 5NG, Surrey, England.
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- Li, Ni (author)
- Inst Canc Res, Div Genet & Epidemiol, 15 Cotswold Rd, Sutton SM2 5NG, Surrey, England.
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- Weinhold, Niels (author)
- Univ Arkansas Med Sci, Myeloma Inst Res & Therapy, Little Rock, AR 72205 USA.;Heidelberg Univ, Dept Internal Med, D-69117 Heidelberg, Germany.
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show more...
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- Försti, Asta (author)
- Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups,German Cancer Research Centre,German Canc Res Ctr, D-69120 Heidelberg, Germany.;Lund Univ, Ctr Primary Hlth Care Res, SE-20502 Malmo, Sweden.
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- Ali, Mina (author)
- Lund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine,Dept Lab Med, Hematol & Transfus Med, BMC B13, SE-22184 Lund, Sweden.
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- van Duin, Mark (author)
- Erasmus MC Canc Inst, Dept Hematol, NL-3075 EA Rotterdam, Netherlands.,Erasmus University Medical Center
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- Thorleifsson, Gudmar (author)
- deCODE Genet, Sturlugata 8, IS-101 Reykjavik, Iceland.,deCODE Genetics
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- Johnson, David C. (author)
- Inst Canc Res, Div Mol Pathol, Sutton SM2 5NG, Surrey, England.,German Canc Res Ctr, D-69120 Heidelberg, Germany.
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- Chen, Bowang (author)
- German Canc Res Ctr, D-69120 Heidelberg, Germany.,German Cancer Research Centre
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- Halvarsson, Britt-Marie (author)
- Lund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine,Dept Lab Med, Hematol & Transfus Med, BMC B13, SE-22184 Lund, Sweden.
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- Gudbjartsson, Daniel F. (author)
- deCODE Genet, Sturlugata 8, IS-101 Reykjavik, Iceland.;Univ Iceland, Sch Engn & Nat Sci, IS-101 Reykjavik, Iceland.
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- Kuiper, Rowan (author)
- Erasmus MC Canc Inst, Dept Hematol, NL-3075 EA Rotterdam, Netherlands.,Erasmus University Medical Center
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- Stephens, Owen W. (author)
- Univ Arkansas Med Sci, Myeloma Inst Res & Therapy, Little Rock, AR 72205 USA.
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- Bertsch, Uta (author)
- Heidelberg Univ, Dept Internal Med, D-69117 Heidelberg, Germany.;Natl Ctr Tumor Dis, D-69120 Heidelberg, Germany.
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- Broderick, Peter (author)
- Inst Canc Res, Div Genet & Epidemiol, 15 Cotswold Rd, Sutton SM2 5NG, Surrey, England.
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- Campo, Chiara (author)
- German Canc Res Ctr, D-69120 Heidelberg, Germany.
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- Einsele, Hermann (author)
- Univ Clin Wurzburg, D-97080 Wurzburg, Germany.
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- Gregory, Walter A. (author)
- Univ Leeds, Clin Trials Res Unit, Leeds LS2 9PH, W Yorkshire, England.
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- Gullberg, Urban (author)
- Lund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine,Dept Lab Med, Hematol & Transfus Med, BMC B13, SE-22184 Lund, Sweden.
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- Henrion, Marc (author)
- Inst Canc Res, Div Genet & Epidemiol, 15 Cotswold Rd, Sutton SM2 5NG, Surrey, England.
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- Hillengass, Jens (author)
- Heidelberg Univ, Dept Internal Med, D-69117 Heidelberg, Germany.
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- Hoffmann, Per (author)
- Univ Bonn, Inst Human Genet, D-53127 Bonn, Germany.;Univ Basel, Div Med Genet, Dept Biomed, CH-4003 Basel, Switzerland.
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- Jackson, Graham H. (author)
- Royal Victoria Infirm, Newcastle Upon Tyne NE1 4LP, Tyne & Wear, England.
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- Johnsson, Ellinor (author)
- Lund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine,Dept Lab Med, Hematol & Transfus Med, BMC B13, SE-22184 Lund, Sweden.
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- Jöud, Magnus (author)
- Lund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine,Dept Lab Med, Hematol & Transfus Med, BMC B13, SE-22184 Lund, Sweden.;Off Med Serv, Clin Immunol & Transfus Med, Lab Med, SE-22185 Lund, Sweden.
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- Kristinsson, Sigurjdur Y. (author)
- Karolinska Institutet,Natl Univ Hosp Iceland, Dept Hematol, Landspitali, IS-101 Reykjavik, Iceland.
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- Lenhoff, Stig (author)
- Lund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine,Skåne University Hospital,Skane Univ Hosp, Hematol Clin, SE-22185 Lund, Sweden.
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- Lenive, Oleg (author)
- Inst Canc Res, Div Genet & Epidemiol, 15 Cotswold Rd, Sutton SM2 5NG, Surrey, England.
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- Mellqvist, Ulf-Henrik (author)
- Sahlgrens Univ Hosp, Sect Hematol, S-41345 Gothenburg, Sweden.
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- Migliorini, Gabriele (author)
- Inst Canc Res, Div Genet & Epidemiol, 15 Cotswold Rd, Sutton SM2 5NG, Surrey, England.
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- Nahi, Hareth (author)
- Karolinska Institutet,Karolinska Inst, Ctr Hematol & Regenerat Med, SE-17177 Stockholm, Sweden.
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- Nelander, Sven (author)
- Uppsala universitet,Neuroonkologi
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- Nickel, Jolanta (author)
- Heidelberg Univ, Dept Internal Med, D-69117 Heidelberg, Germany.
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- Nöthen, Markus M. (author)
- Univ Bonn, Inst Human Genet, D-53127 Bonn, Germany.;Univ Bonn, Dept Genom, Life & Brain Ctr, D-53127 Bonn, Germany.
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- Rafnar, Thorunn (author)
- deCODE Genet, Sturlugata 8, IS-101 Reykjavik, Iceland.
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- Ross, Fiona M. (author)
- Univ Southampton, Wessex Reg Genet Lab, Salisbury SP2 8BJ, Wilts, England.
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- da Silva Filho, Miguel Inacio (author)
- German Canc Res Ctr, D-69120 Heidelberg, Germany.
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- Swaminathan, Bhairavi (author)
- Lund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine,Dept Lab Med, Hematol & Transfus Med, BMC B13, SE-22184 Lund, Sweden.
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- Thomsen, Hauke (author)
- German Canc Res Ctr, D-69120 Heidelberg, Germany.
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- Turesson, Ingemar (author)
- Lund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine,Skåne University Hospital,Skane Univ Hosp, Hematol Clin, SE-22185 Lund, Sweden.
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- Vangsted, Annette (author)
- Rigshosp, Univ Copenhagen Hosp, Dept Haematol, Blegdamsvej 9, DK-2100 Copenhagen, Denmark.
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- Vogel, Ulla (author)
- Natl Res Ctr Working Environm, DK-2100 Copenhagen, Denmark.
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- Waage, Anders (author)
- Norwegian Univ Sci & Technol, Dept Canc Res & Mol Med, Box 8905, N-7491 Trondheim, Norway.
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- Walker, Brian A. (author)
- Univ Arkansas Med Sci, Myeloma Inst Res & Therapy, Little Rock, AR 72205 USA.
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- Wihlborg, Anna-Karin (author)
- Lund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine,Dept Lab Med, Hematol & Transfus Med, BMC B13, SE-22184 Lund, Sweden.
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- Broyl, Annemiek (author)
- Erasmus MC Canc Inst, Dept Hematol, NL-3075 EA Rotterdam, Netherlands.
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- Davies, Faith E. (author)
- Univ Arkansas Med Sci, Myeloma Inst Res & Therapy, Little Rock, AR 72205 USA.
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- Thorsteinsdottir, Unnur (author)
- deCODE Genet, Sturlugata 8, IS-101 Reykjavik, Iceland.;Univ Iceland, Fac Med, IS-101 Reykjavik, Iceland.
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- Langer, Christian (author)
- Univ Ulm, Dept Internal Med 3, D-89081 Ulm, Germany.
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- Hansson, Markus (author)
- Lund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine,Skåne University Hospital,Dept Lab Med, Hematol & Transfus Med, BMC B13, SE-22184 Lund, Sweden.;Skane Univ Hosp, Hematol Clin, SE-22185 Lund, Sweden.
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- Kaiser, Martin (author)
- Inst Canc Res, Div Mol Pathol, Sutton SM2 5NG, Surrey, England.
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- Sonneveld, Pieter (author)
- Erasmus MC Canc Inst, Dept Hematol, NL-3075 EA Rotterdam, Netherlands.
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- Stefansson, Kari (author)
- deCODE Genet, Sturlugata 8, IS-101 Reykjavik, Iceland.
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- Morgan, Gareth J. (author)
- Univ Arkansas Med Sci, Myeloma Inst Res & Therapy, Little Rock, AR 72205 USA.
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- Goldschmidt, Hartmut (author)
- Heidelberg Univ, Dept Internal Med, D-69117 Heidelberg, Germany.;Natl Ctr Tumor Dis, D-69120 Heidelberg, Germany.
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- Hemminki, Kari (author)
- Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups,German Cancer Research Centre,German Canc Res Ctr, D-69120 Heidelberg, Germany.;Lund Univ, Ctr Primary Hlth Care Res, SE-20502 Malmo, Sweden.
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- Nilsson, Björn (author)
- Lund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine,Broad Institute,Dept Lab Med, Hematol & Transfus Med, BMC B13, SE-22184 Lund, Sweden.;Off Med Serv, Clin Immunol & Transfus Med, Lab Med, SE-22185 Lund, Sweden.;Broad Inst, 7 Cambridge Ctr, Cambridge, MA 02142 USA.
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- Houlston, Richard S. (author)
- Inst Canc Res, Div Genet & Epidemiol, 15 Cotswold Rd, Sutton SM2 5NG, Surrey, England.
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Inst Canc Res, Div Genet & Epidemiol, 15 Cotswold Rd, Sutton SM2 5NG, Surrey, England Univ Arkansas Med Sci, Myeloma Inst Res & Therapy, Little Rock, AR 72205 USA.;Heidelberg Univ, Dept Internal Med, D-69117 Heidelberg, Germany. (creator_code:org_t)
- 2016-07-01
- 2016
- English.
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In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 7
- Related links:
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Abstract
Subject headings
Close
- Multiple myeloma (MM) is a plasma cell malignancy with a significant heritable basis. Genome-wide association studies have transformed our understanding of MM predisposition, but individual studies have had limited power to discover risk loci. Here we perform a meta-analysis of these GWAS, add a new GWAS and perform replication analyses resulting in 9,866 cases and 239,188 controls. We confirm all nine known risk loci and discover eight new loci at 6p22.3 (rs34229995, P = 1.31 x 10(-8)), 6q21 (rs9372120, P = 9.09 x 10(-15)), 7q36.1 (rs7781265, P = 9.71 x 10(-9)), 8q24.21 (rs1948915, P = 4.20 x 10(-11)), 9p21.3 (rs2811710, P = 1.72 x 10(-13)), 10p12.1 (rs2790457, P = 1.77 x 10(-8)), 16q23.1 (rs7193541, P = 5.00 x 10(-12)) and 20q13.13 (rs6066835, P = 1.36 x 10(-13)), which localize in or near to JARID2, ATG5, SMARCD3, CCAT1, CDKN2A, WAC, RFWD3 and PREX1. These findings provide additional support for a polygenic model of MM and insight into the biological basis of tumour development.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Mitchell, Jonath ...
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Li, Ni
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Weinhold, Niels
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Försti, Asta
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Ali, Mina
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van Duin, Mark
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show more...
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Thorleifsson, Gu ...
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Johnson, David C ...
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Chen, Bowang
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Halvarsson, Brit ...
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Gudbjartsson, Da ...
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Kuiper, Rowan
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Stephens, Owen W ...
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Bertsch, Uta
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Broderick, Peter
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Campo, Chiara
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Einsele, Hermann
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Gregory, Walter ...
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Gullberg, Urban
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Henrion, Marc
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Hillengass, Jens
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Hoffmann, Per
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Jackson, Graham ...
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Johnsson, Ellino ...
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Jöud, Magnus
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Kristinsson, Sig ...
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Lenhoff, Stig
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Lenive, Oleg
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Mellqvist, Ulf-H ...
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Migliorini, Gabr ...
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Nahi, Hareth
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Nelander, Sven
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Nickel, Jolanta
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Nöthen, Markus M ...
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Rafnar, Thorunn
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Ross, Fiona M.
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da Silva Filho, ...
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Swaminathan, Bha ...
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Thomsen, Hauke
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Turesson, Ingema ...
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Vangsted, Annett ...
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Vogel, Ulla
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Waage, Anders
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Walker, Brian A.
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Wihlborg, Anna-K ...
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Broyl, Annemiek
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Davies, Faith E.
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Thorsteinsdottir ...
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Langer, Christia ...
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Hansson, Markus
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Kaiser, Martin
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Sonneveld, Piete ...
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Stefansson, Kari
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Morgan, Gareth J ...
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Goldschmidt, Har ...
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Hemminki, Kari
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Nilsson, Björn
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Houlston, Richar ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Nature Communica ...
- By the university
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Uppsala University
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Lund University
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Karolinska Institutet