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Genome-wide associa...
Genome-wide association meta-analysis of circulating odd-numbered chain saturated fatty acids : Results from the CHARGE Consortium
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- Otto, Marcia C. de Oliveira (author)
- Univ Texas Hlth Sci Ctr Houston, Sch Publ Hlth, Div Epidemiol Human Genet & Environm Sci, Houston, TX USA
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- Lemaitre, Rozenn N. (author)
- Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA USA
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- Sun, Qi (author)
- Harvard TH Chan Sch Publ Hlth, Dept Nutr & Epidemiol, Boston, MA USA; Channing Div Network Med, Boston, MA USA; Harvard Med Sch, Boston, MA USA
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- King, Irena B. (author)
- Univ New Mexico, Albuquerque, NM USA
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- Wu, Jason H. Y. (author)
- Univ New South Wales, George Inst Global Hlth, Sydney, NSW, Australia; Univ New South Wales, Fac Med, Sydney, NSW, Australia
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- Manichaikul, Ani (author)
- Univ Virginia, Ctr Publ Hlth Genom, Charlottesville, VA USA
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- Rich, Stephen S. (author)
- Univ Virginia, Ctr Publ Hlth Genom, Charlottesville, VA USA
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- Tsai, Michael Y. (author)
- Univ Minnesota, Dept Lab Med & Pathol, Minneapolis, MN USA
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- Chen, Y. D. (author)
- Harbor UCLA Med Ctr, Inst Translat Genom & Populat Sci, Los Angeles Biomed Res Inst, Torrance, CA USA
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- Fornage, Myriam (author)
- Univ Texas Hlth Sci Ctr Houston, Sch Publ Hlth, Key Lab Nutr & Metab, Houston, TX USA
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- Weihua, Guan (author)
- Univ Minnesota, Dept Biostat, Minneapolis, MN USA
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- Aslibekyan, Stella (author)
- Univ Kentucky, Coll Publ Hlth, Lexington, KY USA
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- Irvin, Marguerite R. (author)
- Univ Kentucky, Coll Publ Hlth, Lexington, KY USA
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- Kabagambe, Edmond K. (author)
- Univ Kentucky, Coll Publ Hlth, Lexington, KY USA
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- Arnett, Donna K. (author)
- Univ Kentucky, Coll Publ Hlth, Lexington, KY USA
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- Jensen, Majken K. (author)
- Harvard TH Chan Sch Publ Hlth, Dept Nutr & Epidemiol, Boston, MA USA;Harvard Med Sch, Boston, MA USA;Brigham & Womens Hosp, Boston, MA USA
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- McKnight, Barbara (author)
- Univ Washington, Dept Biostat, Seattle, WA USA
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- Psaty, Bruce M. (author)
- Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA USA; Kaiser Permanente Washington Hlth Res Inst, Seattle, WA USA
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- Steffen, Lyn M. (author)
- Univ Minnesota, Sch Publ Hlth, Div Epidemiol & Community Hlth, Minneapolis, MN USA
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- Smith, Caren E. (author)
- Tufts Univ, Jean Mayer USDA HNRCA, Nutr & Genom Lab, Boston, MA USA
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- Risérus, Ulf, 1967- (author)
- Uppsala universitet,Klinisk nutrition och metabolism
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- Lind, Lars (author)
- Uppsala universitet,Kardiovaskulär epidemiologi
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- Hu, Frank B. (author)
- Harvard TH Chan Sch Publ Hlth, Dept Nutr & Epidemiol, Boston, MA USA; Channing Div Network Med, Boston, MA USA; Harvard Med Sch, Boston, MA USA
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- Rimm, Eric B. (author)
- Harvard TH Chan Sch Publ Hlth, Dept Nutr & Epidemiol, Boston, MA USA; Channing Div Network Med, Boston, MA USA; Harvard Med Sch, Boston, MA USA
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- Siscovick, David S. (author)
- New York Acad Med, New York, NY USA
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- Mozaffarian, Dariush (author)
- Tufts Univ, Friedman Sch Nutr Sci & Policy, Boston, MA USA
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(creator_code:org_t)
- 2018-05-08
- 2018
- English.
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In: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 13:5
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https://doi.org/10.1...
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Abstract
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- Background: Odd-numbered chain saturated fatty acids (OCSFA) have been associated with potential health benefits. Although some OCSFA (e.g., C15:0 and C17:0) are found in meats and dairy products, sources and metabolism of C19:0 and C23:0 are relatively unknown, and the influence of non-dietary determinants, including genetic factors, on circulating levels of OCSFA is not established.Objective: To elucidate the biological processes that influence circulating levels of OCSFA by investigating associations between genetic variation and OCSFA.Design: We performed a meta-analysis of genome-wide association studies (GWAS) of plasma phospholipid/erythrocyte levels of C15:0, C17:0, C19:0, and C23:0 among 11,494 individuals of European descent. We also investigated relationships between specific single nucleotide polymorphisms (SNPs) in the lactase (LCT) gene, associated with adult-onset lactase intolerance, with circulating levels of dairy-derived OCSFA, and evaluated associations of candidate sphingolipid genes with C23:0 levels.Results: We found no genome-wide significant evidence that common genetic variation is associated with circulating levels of C15:0 or C23:0. In two cohorts with available data, we identified one intronic SNP (rs13361131) in myosin X gene (MYO10) associated with C17:0 level (P = 1.37×10−8), and two intronic SNP (rs12874278 and rs17363566) in deleted in lymphocytic leukemia 1 (DLEU1) region associated with C19:0 level (P = 7.07×10−9). In contrast, when using a candidate-gene approach, we found evidence that three SNPs in LCT (rs11884924, rs16832067, and rs3816088) are associated with circulating C17:0 level (adjusted P = 4×10−2). In addition, nine SNPs in the ceramide synthase 4 (CERS4) region were associated with circulating C23:0 levels (adjusted P<5×10−2).Conclusions: Our findings suggest that circulating levels of OCSFA may be predominantly influenced by non-genetic factors. SNPs associated with C17:0 level in the LCT gene may reflect genetic influence in dairy consumption or in metabolism of dairy foods. SNPs associated with C23:0 may reflect a role of genetic factors in the synthesis of sphingomyelin.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
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Otto, Marcia C. ...
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Lemaitre, Rozenn ...
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Sun, Qi
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King, Irena B.
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Wu, Jason H. Y.
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Manichaikul, Ani
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show more...
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Rich, Stephen S.
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Tsai, Michael Y.
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Chen, Y. D.
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Fornage, Myriam
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Weihua, Guan
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Aslibekyan, Stel ...
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Irvin, Marguerit ...
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Kabagambe, Edmon ...
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Arnett, Donna K.
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Jensen, Majken K ...
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McKnight, Barbar ...
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Psaty, Bruce M.
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Steffen, Lyn M.
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Smith, Caren E.
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Risérus, Ulf, 19 ...
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Lind, Lars
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Hu, Frank B.
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Rimm, Eric B.
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Siscovick, David ...
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Mozaffarian, Dar ...
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- MEDICAL AND HEALTH SCIENCES
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Uppsala University