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  • Houtman, MirandaKarolinska Institutet (author)

T cells are influenced by a long non-coding RNA in the autoimmune associated PTPN2 locus

  • Article/chapterEnglish2018

Publisher, publication year, extent ...

  • ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD,2018
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-357383
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-357383URI
  • https://doi.org/10.1016/j.jaut.2018.01.003DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:138396170URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Non-coding SNPs in the protein tyrosine phosphatase non-receptor type 2 (PTPN2) locus have been linked with several autoimmune diseases, including rheumatoid arthritis, type I diabetes, and inflammatory bowel disease. However, the functional consequences of these SNPs are poorly characterized. Herein, we show in blood cells that SNPs in the PTPN2 locus are highly correlated with DNA methylation levels at four CpG sites downstream of PTPN2 and expression levels of the long non-coding RNA (IncRNA) LINC01882 downstream of these CpG sites. We observed that LINC01882 is mainly expressed in T cells and that anti-CD3/CD28 activated naive CD4(+) T cells downregulate the expression of LINC01882. RNA sequencing analysis of LINC01882 knockdown in Jurkat T cells, using a combination of antisense oligo-nucleotides and RNA interference, revealed the upregulation of the transcription factor ZEB1 and kinase MAP2K4, both involved in IL-2 regulation. Overall, our data suggests the involvement of LINC01882 in T cell activation and hints towards an auxiliary role of these non-coding SNPs in autoimmunity associated with the PTPN2 locus. 

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Shchetynsky, KlementyKarolinska Institutet (author)
  • Chemin, KarineKarolinska Institutet (author)
  • Hensvold, Aase HajKarolinska Institutet (author)
  • Ramsköld, DanielKarolinska Institutet (author)
  • Tandre, KarolinaUppsala universitet,Reumatologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)karotand (author)
  • Eloranta, Maija-LeenaUppsala universitet,Reumatologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)maelo020 (author)
  • Rönnblom, LarsUppsala universitet,Reumatologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)larsronn (author)
  • Uebe, SteffenUniv Erlangen Nurnberg, Inst Human Genet, Erlangen, Germany (author)
  • Catrina, Anca IrinelKarolinska Institutet (author)
  • Malmström, VivianneKarolinska Institutet (author)
  • Padyukov, LeonidKarolinska Institutet (author)
  • Karolinska InstitutetReumatologi (creator_code:org_t)

Related titles

  • In:Journal of Autoimmunity: ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD90, s. 28-380896-84111095-9157

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