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Genetic analyses of Seoul hantavirus genome recovered from rats (Rattus norvegicus) in the Netherlands unveils diverse routes of spread into Europe

Ling, Jiaxin (author)
Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
Verner-Carlsson, Jenny (author)
Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
Eriksson, Per (author)
Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
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Plyusnina, Angelina (author)
Univ Helsinki, Dept Virol, Med, Helsinki, Finland
Löhmus, Mare (author)
Karolinska Institutet,Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Karolinska Inst, Inst Environm Med, Stockholm, Sweden;Stockholm Cty Council, Ctr Occupat & Environm Med, Stockholm, Sweden;Natl Vet Inst, Uppsala, Sweden
Järhult, Josef D., 1975- (author)
Uppsala universitet,Infektionssjukdomar
van de Goot, Frank (author)
Symbiant Pathol Expert Ctr, Alkmaar, Netherlands
Plyusnin, Alexander (author)
Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Univ Helsinki, Dept Virol, Med, Helsinki, Finland
Lundkvist, Åke (author)
Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
Sironen, Tarja (author)
Univ Helsinki, Dept Virol, Med, Helsinki, Finland
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 (creator_code:org_t)
2019-01-15
2019
English.
In: Journal of Medical Virology. - : WILEY. - 0146-6615 .- 1096-9071. ; 91:5, s. 724-730
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Seoul virus (SEOV) is the etiologic agent of hemorrhagic fever with renal syndrome. It is carried by brown rats (Rattus norvegicus), a commensal rodent that closely cohabitates with humans in urban environments. SEOV has a worldwide distribution, and in Europe, it has been found in rats in UK, France, Sweden, and Belgium, and human cases of SEOV infection have been reported in Germany, UK, France, and Belgium. In the search of hantaviruses in brown rats from the Netherlands, we found both serological and genetic evidence for the presence of SEOV in the local wild rat population. To further decipher the relationship with other SEOV variants globally, the complete genome of SEOV in the Netherlands was recovered. SEOV sequences obtained from three positive rats (captured at close trapping locations at the same time) were found highly similar. Phylogenetic analyses demonstrated that two lineages of SEOV circulate in Europe. Strains from the Netherlands and UK, together with the Baxter strain from US, constitute one of these two, while the second includes strains from Europe and Asia. Our results support a hypothesis of diverse routes of SEOV spread into Europe. These findings, combined with other indications on the expansion of the spatial European range of SEOV, suggest an increased risk of this virus for the public health, highlighting the need for increased surveillance.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Infectious Medicine (hsv//eng)

Keyword

hantavirus
hemorrhagic fever with renal syndrome
phylogenetic analysis
Seoul virus

Publication and Content Type

ref (subject category)
art (subject category)

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