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  • Lamarca, Angela (author)

Tumour Growth Rate as a validated early radiological biomarker able to reflect treatment-induced changes in Neuroendocrine Tumours : the GREPONET-2 study

  • Article/chapterEnglish2019

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  • 2019
  • printrdacarrier

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  • LIBRIS-ID:oai:DiVA.org:uu-392838
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-392838URI
  • https://doi.org/10.1158/1078-0432.CCR-19-0963DOI

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  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

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  • PURPOSE: TGR represents the percentage change in tumour volume per month (%/m). Previous results from the GREPONET study showed that TGR measured after 3 months (TGR3m) of starting systemic treatment (ST) or watch and wait (WW) was an early biomarker predicting progression-free survival (PFS) in NETs.EXPERIMENTAL DESIGN: Pts from7 centres with advanced grade(G) 1/2 NETs from the pancreas(P)/small bowel(SB) initiating ST/WW were eligible. Computed tomography (CT) / magnetic resonance imaging (MRI) performed at pre-baseline, baseline and 3(+/-1) months of study entry were retrospectively reviewed. Aim-1: explore treatment-induced changes in TGR (ΔTGR3m-BL) (paired T-test) and Aim-2: validate TGR3m (<0.8%/m vs ≥0.8%/m) as an early biomarker in an independent cohort (Kaplan-Meier/Cox Regression).RESULTS: Out of 785 pts screened, 127 were eligible. Mean (SD) TGR0 and TGR3m were 5.4%/m (14.9) and -1.4%/m (11.8), respectively. Mean(SD) ΔTGR3m-BL paired-difference was -6.8%/m(19.3) (p<0.001). Most marked ΔTGR3m-BL (mean (SD);p) were identified with targeted therapies (-11.3%/m(4.7);0.0237) and chemotherapy (-7.9%/m(3.4);0.0261). Multivariable analysis confirmed the absence of previous treatment (Odds Ratio (OR) 4.65 (95%CI 1.31-16.52); p-value0.018) and low TGR3m (continuous variable; OR 1.09 (95%CI 1.01-1.19); p-value0.042) to be independent predictors of radiological objective response. When the multivariable Cox Regression was adjusted to grade (p-value 0.004) and stage (p-value0.017), TGR3m≥0.8 (vs.<0.8) maintained its significance (p<0.001), while TGR0 and ΔTGR3m-BL did not. TGR3m was confirmed as an independent prognosis factor for PFS (external validation; Aim-2) (multivariable HR 2.21 (95%CI 1.21-3.70); p-value0.003).CONCLUSIONS: TGR has a role as biomarker for monitoring response to therapy for early prediction of PFS and radiological objective response.

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  • Ronot, Maxime (author)
  • Moalla, Salma (author)
  • Crona, JoakimUppsala universitet,Endokrin tumörbiologi(Swepub:uu)joacr310 (author)
  • Opalinska, Marta (author)
  • Lopez Lopez, Carlos (author)
  • Pezzutti, Daniela (author)
  • Najran, Pavan (author)
  • Carvalho, Luciana Franco do Prado de (author)
  • Bezerra, Regis Otaviano Franca (author)
  • Borg, Philip (author)
  • Vietti Violi, Naik (author)
  • Vidal Trueba, Hector (author)
  • de Mestier, Louis (author)
  • Schaefer, Niklaus (author)
  • Baudin, Eric (author)
  • Sundin, Anders,1954-Uppsala universitet,Radiologi(Swepub:uu)anderssu (author)
  • Costa, Frederico P (author)
  • Pavel, Marianne (author)
  • Dromain, Clarisse (author)
  • Uppsala universitetEndokrin tumörbiologi (creator_code:org_t)

Related titles

  • In:Clinical Cancer Research15:25, s. 6692-66991078-04321557-3265

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