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Association of the ...
Association of the coronary artery disease risk gene GUCY1A3 with ischaemic events after coronary intervention
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- Kessler, Thorsten (author)
- Tech Univ Munich, Deutsch Herzzentrum Munchen, Klin Herz & Kreislauferkrankungen, Munich, Germany;Deutsch Zentrum Herz Kreislauf Forsch DZHK eV, Partner Site Munich Heart Alliance, Munich, Germany
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- Wolf, Bernhard (author)
- Tech Univ Munich, Deutsch Herzzentrum Munchen, Klin Herz & Kreislauferkrankungen, Munich, Germany;Deutsch Zentrum Herz Kreislauf Forsch DZHK eV, Partner Site Munich Heart Alliance, Munich, Germany
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- Eriksson, Niclas, 1978- (author)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR)
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- Kofink, Daniel (author)
- Univ Utrecht, Univ Med Ctr Utrecht, Dept Cardiol, Div Heart & Lungs, Utrecht, Netherlands
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- Mahmoodi, Bakhtawar K. (author)
- St Antonius Hosp, Cardiol Dept, Nieuwegein, Netherlands
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- Rai, Himanshu (author)
- Tech Univ Munich, Deutsch Herzzentrum Munchen, Klin Herz & Kreislauferkrankungen, Munich, Germany
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- Tragante, Vinicius (author)
- Univ Utrecht, Univ Med Ctr Utrecht, Dept Cardiol, Div Heart & Lungs, Utrecht, Netherlands
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- Åkerblom, Axel, 1977- (author)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR)
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- Becker, Richard C. (author)
- Univ Cincinnati, Heart Lung & Vasc Inst, Div Cardiovasc Hlth & Dis, Cincinnati, OH USA
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- Bernlochner, Isabell (author)
- Tech Univ Munich, Klinikum Rechts Isar, Med Klin & Poliklin 1, Munich, Germany
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- Bopp, Roman (author)
- Tech Univ Munich, Deutsch Herzzentrum Munchen, Klin Herz & Kreislauferkrankungen, Munich, Germany
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- James, Stefan, 1964- (author)
- Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)
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- Katus, Hugo A. (author)
- Heidelberg Univ, Innere Med Kardiol Angiol & Pneumol 3, Heidelberg, Germany;DZHK eV, Partner Site Heidelberg, Heidelberg, Germany
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- Mayer, Katharina (author)
- Tech Univ Munich, Deutsch Herzzentrum Munchen, Klin Herz & Kreislauferkrankungen, Munich, Germany
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- Munz, Matthias (author)
- Univ Lubeck, Inst Cardiogenet, Lubeck, Germany;Univ Heart Ctr Lubeck, Lubeck, Germany;DZHK eV, Partner Site Hamburg Kiel Lubeck, Lubeck, Germany;Charite Univ Med Berlin, Berlin, Germany;Free Univ Berlin, Berlin, Germany;Humboldt Univ, Berlin, Germany;Berlin Inst Hlth, Inst Dent & Craniofacial Sci, Dept Periodontol & Synopt Dent, Berlin, Germany
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- Nordio, Francesco (author)
- Brigham & Womens Hosp, TIMI Study Grp, 75 Francis St, Boston, MA 02115 USA
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- O'Donoghue, Michelle L. (author)
- Brigham & Womens Hosp, TIMI Study Grp, 75 Francis St, Boston, MA 02115 USA
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- Sager, Hendrik B. (author)
- Tech Univ Munich, Deutsch Herzzentrum Munchen, Klin Herz & Kreislauferkrankungen, Munich, Germany;Deutsch Zentrum Herz Kreislauf Forsch DZHK eV, Partner Site Munich Heart Alliance, Munich, Germany
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- Sibbing, Dirk (author)
- Deutsch Zentrum Herz Kreislauf Forsch DZHK eV, Partner Site Munich Heart Alliance, Munich, Germany;Ludwig Maximilians Univ Munchen, Klinikum Univ Munchen, Med Klin & Poliklin 1, Munich, Germany
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- Solakov, Linda (author)
- Tech Univ Munich, Deutsch Herzzentrum Munchen, Klin Herz & Kreislauferkrankungen, Munich, Germany
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- Storey, Robert F. (author)
- Univ Sheffield, Dept Infect Immun & Cardiovasc Dis, Sheffield, S Yorkshire, England
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- Wobst, Jana (author)
- Tech Univ Munich, Deutsch Herzzentrum Munchen, Klin Herz & Kreislauferkrankungen, Munich, Germany;Deutsch Zentrum Herz Kreislauf Forsch DZHK eV, Partner Site Munich Heart Alliance, Munich, Germany
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- Asselbergs, Folkert W. (author)
- Univ Utrecht, Univ Med Ctr Utrecht, Dept Cardiol, Div Heart & Lungs, Utrecht, Netherlands;Fac Populat Hlth Sci, Inst Cardiovasc Sci, London, England;UCL, Hlth Data Res UK, London, England;UCL, Inst Hlth Informat, London, England
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- Byrne, Robert A. (author)
- Tech Univ Munich, Deutsch Herzzentrum Munchen, Klin Herz & Kreislauferkrankungen, Munich, Germany
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- Erdmann, Jeanette (author)
- Univ Lubeck, Inst Cardiogenet, Lubeck, Germany;Univ Heart Ctr Lubeck, Lubeck, Germany;DZHK eV, Partner Site Hamburg Kiel Lubeck, Lubeck, Germany
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- Koenig, Wolfgang (author)
- Tech Univ Munich, Deutsch Herzzentrum Munchen, Klin Herz & Kreislauferkrankungen, Munich, Germany;Deutsch Zentrum Herz Kreislauf Forsch DZHK eV, Partner Site Munich Heart Alliance, Munich, Germany
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- Laugwitz, Karl-Ludwig (author)
- Deutsch Zentrum Herz Kreislauf Forsch DZHK eV, Partner Site Munich Heart Alliance, Munich, Germany;Tech Univ Munich, Klinikum Rechts Isar, Med Klin & Poliklin 1, Munich, Germany
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- ten Berg, Jurrien M. (author)
- St Antonius Hosp, Cardiol Dept, Nieuwegein, Netherlands
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- Wallentin, Lars, 1943- (author)
- Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)
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- Kastrati, Adnan (author)
- Tech Univ Munich, Deutsch Herzzentrum Munchen, Klin Herz & Kreislauferkrankungen, Munich, Germany;Deutsch Zentrum Herz Kreislauf Forsch DZHK eV, Partner Site Munich Heart Alliance, Munich, Germany
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- Schunkert, Heribert (author)
- Tech Univ Munich, Deutsch Herzzentrum Munchen, Klin Herz & Kreislauferkrankungen, Munich, Germany;Deutsch Zentrum Herz Kreislauf Forsch DZHK eV, Partner Site Munich Heart Alliance, Munich, Germany
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(creator_code:org_t)
- 2019-02-14
- 2019
- English.
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In: Cardiovascular Research. - : OXFORD UNIV PRESS. - 0008-6363 .- 1755-3245. ; 115:10, s. 1512-1518
- Related links:
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https://academic.oup...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Aim A common genetic variant at the GUCY1A3 coronary artery disease locus has been shown to influence platelet aggregation. The risk of ischaemic events including stent thrombosis varies with the efficacy of aspirin to inhibit platelet reactivity. This study sought to investigate whether homozygous GUCY1A3 (rs7692387) risk allele carriers display higher on-aspirin platelet reactivity and risk of ischaemic events early after coronary intervention. Methods and results The association of GUCY1A3 genotype and on-aspirin platelet reactivity was analysed in the genetics substudy of the ISAR-ASPI registry (n = 1678) using impedance aggregometry. The clinical outcome cardiovascular death or stent thrombosis within 30 days after stenting was investigated in a meta-analysis of substudies of the ISAR-ASPI registry, the PLATO trial (n = 3236), and the Utrecht Coronary Biobank (n = 1003) comprising a total 5917 patients. Homozygous GUCY1A3 risk allele carriers (GG) displayed increased on-aspirin platelet reactivity compared with non-risk allele (AA/AG) carriers [150 (interquartile range 91-209) vs. 134 (85-194) AU.min, P < 0.01]. More homozygous risk allele carriers, compared with non-risk allele carriers, were assigned to the high-risk group for ischaemic events (>203AU.min; 29.5 vs. 24.2%, P = 0.02). Homozygous risk allele carriers were also at higher risk for cardiovascular death or stent thrombosis (hazard ratio 1.70, 95% confidence interval 1.08-2.68; P = 0.02). Bleeding risk was not altered. Conclusion We conclude that homozygous GUCY1A3 risk allele carriers are at increased risk of cardiovascular death or stent thrombosis within 30 days after coronary stenting, likely due to higher on-aspirin platelet reactivity. Whether GUCY1A3 genotype helps to tailor antiplatelet treatment remains to be investigated.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- On-aspirin platelet reactivity
- Genetic variation
- Stent thrombosis
- Genome-wide association studies
- Platelet aggregation
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Kessler, Thorste ...
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Wolf, Bernhard
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Eriksson, Niclas ...
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Kofink, Daniel
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Mahmoodi, Bakhta ...
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Rai, Himanshu
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Tragante, Vinici ...
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Åkerblom, Axel, ...
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Becker, Richard ...
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Bernlochner, Isa ...
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Bopp, Roman
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James, Stefan, 1 ...
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Katus, Hugo A.
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Mayer, Katharina
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Munz, Matthias
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Nordio, Francesc ...
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O'Donoghue, Mich ...
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Sager, Hendrik B ...
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Sibbing, Dirk
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Solakov, Linda
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Storey, Robert F ...
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Wobst, Jana
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Asselbergs, Folk ...
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Byrne, Robert A.
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Erdmann, Jeanett ...
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Koenig, Wolfgang
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Laugwitz, Karl-L ...
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ten Berg, Jurrie ...
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Wallentin, Lars, ...
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Kastrati, Adnan
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Schunkert, Herib ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
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Cardiovascular R ...
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Uppsala University