A pooled analysis of 14 cohort studies of anthropometric factors and pancreatic cancer risk

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A pooled analysis of 14 cohort studies of anthropometric factors and pancreatic cancer risk

Genkinger, Jeanine M. (författare): Columbia Univ, Mailman Sch Publ Hlth, Dept Epidemiol, New York, NY 10032 USA.

Spiegelman, Donna (författare): Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.;Harvard Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA.

Anderson, Kristin E. (författare): Univ Minnesota, Sch Publ Hlth, Div Epidemiol & Community Hlth, Minneapolis, MN USA.;Univ Minnesota, Masonic Canc Ctr, Minneapolis, MN USA.

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Bernstein, Leslie (författare): City Hope Natl Med Ctr, Div Canc Etiol, Duarte, CA 91010 USA.

van den Brandt, Piet A. (författare): Maastricht Univ, Dept Epidemiol, Sch Oncol & Dev Biol GROW, Maastricht, Netherlands.

Calle, Eugenia E. (författare): Amer Canc Soc, Atlanta, GA 30329 USA.

English, Dallas R. (författare): Canc Council Victoria, Canc Epidemiol Ctr, Melbourne, Vic, Australia.;Univ Melbourne, Melbourne, Vic, Australia.

Folsom, Aaron R. (författare): Univ Minnesota, Sch Publ Hlth, Div Epidemiol & Community Hlth, Minneapolis, MN USA.;Univ Minnesota, Masonic Canc Ctr, Minneapolis, MN USA.

Freudenheim, Jo L. (författare): SUNY Buffalo, Dept Social & Prevent Med, Buffalo, NY 14260 USA.

Fuchs, Charles S. (författare): Brigham & Womens Hosp, Dept Med, Channing Lab, Boston, MA USA.;Harvard Univ, Sch Med, Boston, MA USA.;Dana Farber Canc Inst, Div Med Oncol, Boston, MA 02115 USA.

Giles, Graham G. (författare): Canc Council Victoria, Canc Epidemiol Ctr, Melbourne, Vic, Australia.;Univ Melbourne, Melbourne, Vic, Australia.

Giovannucci, Edward (författare): Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.;Brigham & Womens Hosp, Dept Med, Channing Lab, Boston, MA USA.;Harvard Univ, Sch Med, Boston, MA USA.;Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA.

Horn-Ross, Pamela L. (författare): No Calif Canc Ctr, Fremont, CA USA.

Larsson, Susanna C. (författare): Karolinska Institutet

Leitzmann, Michael (författare): NCI, Nutr Epidemiol Branch, Div Canc Epidemiol & Genet, NIH,DHHS, Bethesda, MD 20892 USA.;Univ Regensburg, Inst Epidemiol & Prevent Med, Regensburg, Germany.

Mannisto, Satu (författare): Natl Inst Hlth & Welf, Dept Hlth Promot & Chron Dis Prevent, Helsinki, Finland.

Marshall, James R. (författare): SUNY Buffalo, Dept Social & Prevent Med, Buffalo, NY 14260 USA.

Miller, Anthony B. (författare): Univ Toronto, Dalla Lana Sch Publ Hlth, Toronto, ON, Canada.

Patel, Alpa V. (författare): Amer Canc Soc, Atlanta, GA 30329 USA.

Rohan, Thomas E. (författare): Albert Einstein Coll Med, Dept Epidemiol & Populat Hlth, Bronx, NY 10467 USA.

Stolzenberg-Solomon, Rachael Z. (författare): NCI, Nutr Epidemiol Branch, Div Canc Epidemiol & Genet, NIH,DHHS, Bethesda, MD 20892 USA.

Verhage, Bas A. J. (författare): Maastricht Univ, Dept Epidemiol, Sch Oncol & Dev Biol GROW, Maastricht, Netherlands.

Virtamo, Jarmo (författare): Natl Inst Hlth & Welf, Dept Hlth Promot & Chron Dis Prevent, Helsinki, Finland.

Willcox, Bradley J. (författare): Univ Hawaii, John A Burns Sch Med, Manoa, HI USA.;Okinawa Res Ctr Longev Sci, Okinawa, Japan.;Pacific Hlth Res Inst, Honolulu, HI USA.;Queens Med Ctr, Honolulu, HI USA.

Wolk, Alicja (författare): Karolinska Institutet

Ziegler, Regina G. (författare): NCI, Epidemiol & Biostat Program, Div Canc Epidemiol & Genet, NIH,DHHS, Bethesda, MD 20892 USA.

Smith-Warner, Stephanie A. (författare): Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.;Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA.

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Columbia Univ, Mailman Sch Publ Hlth, Dept Epidemiol, New York, NY 10032 USA Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.;Harvard Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA. (creator_code:org_t)

2011-03-04
2011
Engelska.
Ingår i: International Journal of Cancer. - : WILEY. - 0020-7136 .- 1097-0215. ; 129:7, s. 1708-1717

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Tidskriftsartikel (refereegranskat)

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Epidemiologic studies of pancreatic cancer risk have reported null or nonsignificant positive associations for obesity, while associations for height have been null. Waist and hip circumference have been evaluated infrequently. A pooled analysis of 14 cohort studies on 846,340 individuals was conducted; 2,135 individuals were diagnosed with pancreatic cancer during follow-up. Study-specific relative risks (RRs) and 95% confidence intervals (CIs) were calculated by Cox proportional hazards models, and then pooled using a random effects model. Compared to individuals with a body mass index (BMI) at baseline between 21-22.9 kg/m(2), pancreatic cancer risk was 47% higher (95% CI:23-75%) among obese (BMI >= 30 kg/m(2)) individuals. A positive association was observed for BMI in early adulthood (pooled multivariate [MV]RR = 1.30, 95%CI = 1.09-1.56 comparing BMI >= 25 kg/m(2) to a BMI between 21 and 22.9 kg/m(2)). Compared to individuals who were not overweight in early adulthood (BMI < 25 kg/m(2)) and not obese at baseline (BMI < 30 kg/m(2)), pancreatic cancer risk was 54% higher (95%CI = 24-93%) for those who were overweight in early adulthood and obese at baseline. We observed a 40% higher risk among individuals who had gained BMI >= 10 kg/m(2) between BMI at baseline and younger ages compared to individuals whose BMI remained stable. Results were either similar or slightly stronger among never smokers. A positive association was observed between waist to hip ratio (WHR) and pancreatic cancer risk (pooled MVRR = 1.35 comparing the highest versus lowest quartile, 95%CI = 1.03-1.78). BMI and WHR were positively associated with pancreatic cancer risk. Maintaining normal body weight may offer a feasible approach to reducing morbidity and mortality from pancreatic cancer.

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Cancer och onkol ...

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Av lärosätet: Uppsala universitet; Karolinska Institutet

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A pooled analysis of 14 cohort studies of anthropometric factors and pancreatic cancer risk

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