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Sökning: onr:"swepub:oai:DiVA.org:uu-431310" > Preclinical atheros...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03916naa a2200469 4500 | |
| 001 | oai:DiVA.org:uu-431310 | |
| 003 | SwePub | |
| 008 | 210114s2020 | |||||||||||000 ||eng| | |
| 009 | oai:prod.swepub.kib.ki.se:144777045 | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4313102 URI |
| 024 | 7 | a https://doi.org/10.1002/brb3.18622 DOI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1447770452 URI |
| 040 | a (SwePub)uud (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Bohman, Hannes,d 1965-u Karolinska Institutet,Uppsala universitet,Barn- och ungdomspsykiatri4 aut0 (Swepub:uu)hanbo757 |
| 245 | 1 0 | a Preclinical atherosclerosis in adolescents with psychotic or bipolar disorders investigated with carotid high-frequency ultrasound. |
| 264 | c 2020-09-30 | |
| 264 | 1 | b Wiley,c 2020 |
| 338 | a electronic2 rdacarrier | |
| 520 | a OBJECTIVE: Early-onset psychosis (EOP) and bipolar disorder (EOBP) (at <18 years of age), are associated with an increased future risk of cardiovascular disease (CVD) and premature death. Yet it is unknown whether the arteries show visible signs of atherosclerosis in EOP and EOBP. This study investigated whether having EOP or EOBP was associated with detectable signs of preclinical atherosclerosis.METHOD: By using 22 MHz high-frequency ultrasound, different layers of the arterial wall of the left common carotid artery (LCCA) were assessed in 77 individuals with EOP (n = 25), EOBP (n = 22), and in age-matched healthy controls (n = 30). Conventional CVD confounders were included in the analyses.RESULTS: Adolescents with EOP and EOBP, compared to controls, had a significantly thicker LCCA intima thickness (0.132 vs. 0.095 mm, p < .001) and intima/media ratio (0.24 vs. 0.17 p < .001). There was a nonsignificant intima difference between EOP and EOBP. Conventional CVD risk factors did not explain the association between EOP/EOBP and intima thickness. In the group of EOP/EOBP, there was a significant correlation between the dose of current antipsychotic medication and intima thickness; however, the correlation was attenuated to a nonsignificant level when adjusted for global function.CONCLUSIONS: Adolescents with EOP or EOBP had an increased LCCA intima thickness, interpreted as a sign of preclinical atherosclerosis. Global function of the disorders was the strongest determinant of intima thickness. The findings, if replicated, might have implications for long-term treatment of EOP and EOBP in order to reduce a future risk of CVD. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng |
| 653 | a adolescents | |
| 653 | a atherosclerosis | |
| 653 | a bipolar disorder | |
| 653 | a psychosis | |
| 653 | a ultrasound | |
| 700 | 1 | a Agartz, Ingridu Karolinska Institutet4 aut |
| 700 | 1 | a Mansouri, Shivau Karolinska Institutet4 aut |
| 700 | 1 | a Naessén, Tordu Uppsala universitet,Institutionen för kvinnors och barns hälsa4 aut0 (Swepub:uu)tordnaes |
| 700 | 1 | a Lundberg, Mathiasu Karolinska Institutet4 aut |
| 710 | 2 | a Uppsala universitetb Barn- och ungdomspsykiatri4 org |
| 773 | 0 | t Brain and Behaviord : Wileyg 10:12q 10:12x 2162-3279x 2162-3279 |
| 856 | 4 | u https://doi.org/10.1002/brb3.1862y Fulltext |
| 856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:1517433/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
| 856 | 4 | u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/brb3.1862 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-431310 |
| 856 | 4 8 | u https://doi.org/10.1002/brb3.1862 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:144777045 |
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