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Nondisplaceable Bin...
Nondisplaceable Binding Is a Potential Confounding Factor in 11C-PBR28 Translocator Protein PET Studies.
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Laurell, Gjertrud L (author)
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- Plavén-Sigray, Pontus (author)
- Karolinska Institutet
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- Jucaite, Aurelija (author)
- Karolinska Institutet
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- Varrone, Andrea (author)
- Karolinska Institutet
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Cosgrove, Kelly P (author)
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Svarer, Claus (author)
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Knudsen, Gitte M (author)
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Ogden, R Todd (author)
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Zanderigo, Francesca (author)
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- Cervenka, Simon (author)
- Karolinska Institutet
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Hillmer, Ansel T (author)
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Schain, Martin (author)
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(creator_code:org_t)
- 2020-07-17
- 2021
- English.
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In: Journal of Nuclear Medicine. - : Society of Nuclear Medicine. - 0161-5505 .- 1535-5667 .- 2159-662X. ; 62:3, s. 412-417
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https://jnm.snmjourn...
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https://urn.kb.se/re...
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Abstract
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- The PET ligand 11C-PBR28 (N-((2-(methoxy-11C)-phenyl)methyl)-N-(6-phenoxy-3-pyridinyl)acetamide) binds to the 18-kDa translocator protein (TSPO), a biomarker of glia. In clinical studies of TSPO, the ligand total distribution volume, VT, is frequently the reported outcome measure. Since VT is the sum of the ligand-specific distribution volume (VS) and the nondisplaceable-binding distribution volume (VND), differences in VND across subjects and groups will have an impact on VTMethods: Here, we used a recently developed method for simultaneous estimation of VND (SIME) to disentangle contributions from VND and VS Data from 4 previously published 11C-PBR28 PET studies were included: before and after a lipopolysaccharide challenge (8 subjects), in alcohol use disorder (14 patients, 15 controls), in first-episode psychosis (16 patients, 16 controls), and in Parkinson disease (16 patients, 16 controls). In each dataset, regional VT estimates were obtained with a standard 2-tissue-compartment model, and brain-wide VND was estimated with SIME. VS was then calculated as VT - VND VND and VS were then compared across groups, within each dataset. Results: A lower VND was found for individuals with alcohol-use disorder (34%, P = 0.00084) and Parkinson disease (34%, P = 0.0032) than in their corresponding controls. We found no difference in VND between first-episode psychosis patients and their controls, and the administration of lipopolysaccharide did not change VNDConclusion: Our findings suggest that in TSPO PET studies, nondisplaceable binding can differ between patient groups and conditions and should therefore be considered.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- 11C-PBR28
- PET
- kinetic modeling
- simultaneous estimation
- translocator protein
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Laurell, Gjertru ...
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Plavén-Sigray, P ...
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Jucaite, Aurelij ...
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Varrone, Andrea
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Cosgrove, Kelly ...
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Svarer, Claus
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show more...
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Knudsen, Gitte M
-
Ogden, R Todd
-
Zanderigo, Franc ...
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Cervenka, Simon
-
Hillmer, Ansel T
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Schain, Martin
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Journal of Nucle ...
- By the university
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Uppsala University
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Karolinska Institutet