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Ki67 and cyclin A a...
Ki67 and cyclin A as prognostic factors in early breast cancer : What are the optimal cut-off values?
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- Ahlin, Cecilia (author)
- Uppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi
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Aaltonen, Kirsimari (author)
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- Amini, Rose-Marie (author)
- Karolinska Institutet,Uppsala universitet,Institutionen för genetik och patologi
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Nevanlinna, Heli (author)
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- Fjällskog, Marie-Louise (author)
- Uppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi
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- Blomqvist, Carl (author)
- Uppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi
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(creator_code:org_t)
- Wiley, 2007
- 2007
- English.
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In: Histopathology. - : Wiley. - 0309-0167 .- 1365-2559. ; 51:4, s. 491-498
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Subject headings
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- AIMS: To find the optimal cut-off values for cyclin A and Ki67 in early breast cancer tumours and to evaluate their prognostic values. METHODS AND RESULTS: Tissue microarray (TMA) slides were constructed from 570 T1-4 N0-1 M0 breast cancer tumours. The TMA slides were stained for cyclin A and Ki67 using immunohistochemistry with commercial antibodies. To investigate the optimal cut-off values for cyclin A, Ki67 average and maximum values the material was split into two parts at cut-offs defined by dividing it into deciles. For each cut-off value the relative risk (RR) for metastasis-free survival (MFS) and overall survival (OS) was calculated comparing patients with high versus low cyclin A or Ki67 expression. When using a cut-off value around the seventh decile, cyclin A and Ki67 score correlated with the highest RR ratio for MFS in the chemotherapy-naïve subgroup. Among patients having received adjuvant chemotherapy, no statistically significant differences in MFS or OS were found. CONCLUSIONS: The optimal cut-off value for cyclin A average is 8% and for cyclin A maximum value 11%; for Ki67 the corresponding values are 15% and 22%. Additional studies are needed to verify these results.
Keyword
- breast cancer
- cut-off value
- cyclin A
- Ki67
- tissue microarray
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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