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A randomized double...
A randomized double-blind study of epicardial left atrial cryoablation for permanent atrial fibrillation in patients undergoing mitral valve surgery: the SWEDish Multicentre Atrial Fibrillation study (SWEDMAF).
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- Blomström-Lundqvist, Carina (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper
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- Johansson, Birgitta, 1960 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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- Berglin, Eva, 1947 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Avd för molekylär och klinisk medicin, Institutionen för medicin vid Sahlgrenska akademin
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- Nilsson, Leif (author)
- Uppsala universitet,Thoraxkirurgi
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- Jensen, Steen (author)
- Umeå universitet,Institutionen för folkhälsa och klinisk medicin,Kardiologi
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- Thelin, Stefan (author)
- Uppsala universitet,Thoraxkirurgi
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Holmgren, Anders (author)
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- Edvardsson, Nils, 1942 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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Källner, Göran (author)
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- Blomström, Per (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper
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(creator_code:org_t)
- 2007-10-17
- 2007
- English.
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In: European heart journal. - : Oxford University Press (OUP). - 0195-668X .- 1522-9645. ; 28:23, s. 2902-8
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Abstract
Subject headings
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- AIMS: The efficacy of epicardial left atrial (LA) cryoablation in eliminating atrial fibrillation (AF) in patients undergoing mitral valve surgery (MVS) is unknown. We hypothesized that MVS combined with LA cryoablation is superior to MVS alone. METHODS AND RESULTS: Sixty-nine patients with permanent AF, included at four centres, underwent MVS with or without epicardial LA cryoablation. The primary endpoint was regained sinus rhythm. Risk factors for failed AF cryoablation were elucidated. Sixty-five out of 69 patients reached the primary endpoint. At 6 and 12 months follow-up, 73.3% of patients who underwent cryoablation had regained sinus rhythm at both follow-ups, compared with 45.7 and 42.9% of patients, respectively, who underwent MVS alone (group differences, at 6 months P = 0.024, after 12 months P = 0.013). The in-hospital complication rate was 11.4% in the MVS group and 26.5% in the cryoablation group (P = 0.110). Risk factors for failed elimination of AF by cryoablation were duration of permanent AF (P = 0.012) and presence of coronary artery disease (P = 0.047), according to multiple logistic regression analysis. CONCLUSION: This first prospective randomized study showed that combining MVS with epicardial LA cryoablation is significantly better in eliminating pre-operative permanent AF than MVS alone.
Keyword
- Adolescent
- Adult
- Aged
- Aged
- 80 and over
- Atrial Fibrillation
- etiology
- surgery
- Catheter Ablation
- methods
- Combined Modality Therapy
- methods
- Cryosurgery
- methods
- Double-Blind Method
- Female
- Follow-Up Studies
- Humans
- Male
- Middle Aged
- Mitral Valve Insufficiency
- surgery
- Prospective Studies
- Ablation
- MEDICINE
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Blomström-Lundqv ...
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Johansson, Birgi ...
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Berglin, Eva, 19 ...
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Nilsson, Leif
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Jensen, Steen
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Thelin, Stefan
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show more...
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Holmgren, Anders
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Edvardsson, Nils ...
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Källner, Göran
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Blomström, Per
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- Articles in the publication
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European heart j ...
- By the university
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University of Gothenburg
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Umeå University
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Uppsala University
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Karolinska Institutet