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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 05463naa a2201165 4500 | |
| 001 | oai:gup.ub.gu.se/132114 | |
| 003 | SwePub | |
| 008 | 240910s2010 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://gup.ub.gu.se/publication/1321142 URI |
| 024 | 7 | a https://doi.org/10.1038/ng.6192 DOI |
| 040 | a (SwePub)gu | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Barretina, Jordi4 aut |
| 245 | 1 0 | a Subtype-specific genomic alterations define new targets for soft-tissue sarcoma therapy. |
| 264 | c 2010-07-04 | |
| 264 | 1 | b Springer Science and Business Media LLC,c 2010 |
| 520 | a Soft-tissue sarcomas, which result in approximately 10,700 diagnoses and 3,800 deaths per year in the United States, show remarkable histologic diversity, with more than 50 recognized subtypes. However, knowledge of their genomic alterations is limited. We describe an integrative analysis of DNA sequence, copy number and mRNA expression in 207 samples encompassing seven major subtypes. Frequently mutated genes included TP53 (17% of pleomorphic liposarcomas), NF1 (10.5% of myxofibrosarcomas and 8% of pleomorphic liposarcomas) and PIK3CA (18% of myxoid/round-cell liposarcomas, or MRCs). PIK3CA mutations in MRCs were associated with Akt activation and poor clinical outcomes. In myxofibrosarcomas and pleomorphic liposarcomas, we found both point mutations and genomic deletions affecting the tumor suppressor NF1. Finally, we found that short hairpin RNA (shRNA)-based knockdown of several genes amplified in dedifferentiated liposarcoma, including CDK4 and YEATS4, decreased cell proliferation. Our study yields a detailed map of molecular alterations across diverse sarcoma subtypes and suggests potential subtype-specific targets for therapy. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Cell- och molekylärbiologi0 (SwePub)301082 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Cell and Molecular Biology0 (SwePub)301082 hsv//eng |
| 650 | 7 | a NATURVETENSKAPx Biologix Genetik0 (SwePub)106092 hsv//swe |
| 650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Genetics0 (SwePub)106092 hsv//eng |
| 650 | 7 | a NATURVETENSKAPx Biologix Cellbiologi0 (SwePub)106042 hsv//swe |
| 650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Cell Biology0 (SwePub)106042 hsv//eng |
| 650 | 7 | a NATURVETENSKAPx Biologix Utvecklingsbiologi0 (SwePub)106142 hsv//swe |
| 650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Developmental Biology0 (SwePub)106142 hsv//eng |
| 653 | a Adult | |
| 653 | a Aged | |
| 653 | a Female | |
| 653 | a Genes | |
| 653 | a Tumor Suppressor | |
| 653 | a Genome | |
| 653 | a Histiocytoma | |
| 653 | a Malignant Fibrous | |
| 653 | a genetics | |
| 653 | a Humans | |
| 653 | a Liposarcoma | |
| 653 | a genetics | |
| 653 | a metabolism | |
| 653 | a pathology | |
| 653 | a Male | |
| 653 | a Middle Aged | |
| 653 | a Mutation | |
| 653 | a Sarcoma | |
| 653 | a genetics | |
| 653 | a pathology | |
| 700 | 1 | a Taylor, Barry S4 aut |
| 700 | 1 | a Banerji, Shantanu4 aut |
| 700 | 1 | a Ramos, Alexis H4 aut |
| 700 | 1 | a Lagos-Quintana, Mariana4 aut |
| 700 | 1 | a Decarolis, Penelope L4 aut |
| 700 | 1 | a Shah, Kinjal4 aut |
| 700 | 1 | a Socci, Nicholas D4 aut |
| 700 | 1 | a Weir, Barbara A4 aut |
| 700 | 1 | a Ho, Alan4 aut |
| 700 | 1 | a Chiang, Derek Y4 aut |
| 700 | 1 | a Reva, Boris4 aut |
| 700 | 1 | a Mermel, Craig H4 aut |
| 700 | 1 | a Getz, Gad4 aut |
| 700 | 1 | a Antipin, Yevgenyi4 aut |
| 700 | 1 | a Beroukhim, Rameen4 aut |
| 700 | 1 | a Major, John E4 aut |
| 700 | 1 | a Hatton, Charles4 aut |
| 700 | 1 | a Nicoletti, Richard4 aut |
| 700 | 1 | a Hanna, Megan4 aut |
| 700 | 1 | a Sharpe, Ted4 aut |
| 700 | 1 | a Fennell, Tim J4 aut |
| 700 | 1 | a Cibulskis, Kristian4 aut |
| 700 | 1 | a Onofrio, Robert C4 aut |
| 700 | 1 | a Saito, Tsuyoshi4 aut |
| 700 | 1 | a Shukla, Neerav4 aut |
| 700 | 1 | a Lau, Christopher4 aut |
| 700 | 1 | a Nelander, Sven,d 1974u Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine4 aut0 (Swepub:gu)xnelsv |
| 700 | 1 | a Silver, Serena J4 aut |
| 700 | 1 | a Sougnez, Carrie4 aut |
| 700 | 1 | a Viale, Agnes4 aut |
| 700 | 1 | a Winckler, Wendy4 aut |
| 700 | 1 | a Maki, Robert G4 aut |
| 700 | 1 | a Garraway, Levi A4 aut |
| 700 | 1 | a Lash, Alex4 aut |
| 700 | 1 | a Greulich, Heidi4 aut |
| 700 | 1 | a Root, David E4 aut |
| 700 | 1 | a Sellers, William R4 aut |
| 700 | 1 | a Schwartz, Gary K4 aut |
| 700 | 1 | a Antonescu, Cristina R4 aut |
| 700 | 1 | a Lander, Eric S4 aut |
| 700 | 1 | a Varmus, Harold E4 aut |
| 700 | 1 | a Ladanyi, Marc4 aut |
| 700 | 1 | a Sander, Chris4 aut |
| 700 | 1 | a Meyerson, Matthew4 aut |
| 700 | 1 | a Singer, Samuel4 aut |
| 710 | 2 | a Göteborgs universitetb Institutionen för medicin4 org |
| 773 | 0 | t Nature geneticsd : Springer Science and Business Media LLCg 42:8, s. 715-21q 42:8<715-21x 1546-1718x 1061-4036 |
| 856 | 4 | u https://europepmc.org/articles/pmc2911503?pdf=render |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/132114 |
| 856 | 4 8 | u https://doi.org/10.1038/ng.619 |
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