Neutralizing granulocyte/macrophage colony-stimulating factor inhibits cigarette smoke-induced lung inflammation.

• Cigarette smoke is the major cause of chronic obstructive pulmonary disease (COPD), and there is currently no satisfactory therapy to treat people with COPD. We have previously shown that granulocyte/macrophage colony-stimulating factor (GM-CSF) regulates lung innate immunity to LPS through Akt/Erk activation of nuclear factor-kappaB and activator protein (AP)-1.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)

Keyword

Animals

Antibodies

Neutralizing

therapeutic use

Granulocyte-Macrophage Colony-Stimulating Factor

antagonists & inhibitors

immunology

Immunity

Innate

Male

Mice

Mice

Inbred BALB C

Pneumonia

immunology

prevention & control

Smoking

immunology

Publication and Content Type

ref (subject category)

art (subject category)