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Eight common geneti...
Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms.
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Zhai, Guangju (author)
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Teumer, Alexander (author)
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Stolk, Lisette (author)
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Perry, John R B (author)
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- Vandenput, Liesbeth, 1974 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin,Centre for Bone and Arthritis Research,Institute of Medicine, Department of Internal Medicine
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Coviello, Andrea D (author)
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Koster, Annemarie (author)
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Bell, Jordana T (author)
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Bhasin, Shalender (author)
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- Eriksson, Joel (author)
- Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research
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- Eriksson, Anna-Lena, 1971 (author)
- Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research,Institutionen för medicin, avdelningen för klinisk prövning och entreprenörskap,Institute of Medicine, Department of Clinical Trials and Entrepreneurship
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Ernst, Florian (author)
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Ferrucci, Luigi (author)
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Frayling, Timothy M (author)
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Glass, Daniel (author)
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Grundberg, Elin (author)
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Haring, Robin (author)
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Hedman, Asa K (author)
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Hofman, Albert (author)
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Kiel, Douglas P (author)
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Kroemer, Heyo K (author)
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Liu, Yongmei (author)
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Lunetta, Kathryn L (author)
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Maggio, Marcello (author)
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- Lorentzon, Mattias, 1970 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin,Centre for Bone and Arthritis Research,Institute of Medicine, Department of Internal Medicine
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Mangino, Massimo (author)
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Melzer, David (author)
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Miljkovic, Iva (author)
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Nica, Alexandra (author)
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Penninx, Brenda W J H (author)
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Vasan, Ramachandran S (author)
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Rivadeneira, Fernando (author)
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Small, Kerrin S (author)
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Soranzo, Nicole (author)
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Uitterlinden, André G (author)
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Völzke, Henry (author)
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Wilson, Scott G (author)
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Xi, Li (author)
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Zhuang, Wei Vivian (author)
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Harris, Tamara B (author)
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Murabito, Joanne M (author)
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- Ohlsson, Claes, 1965 (author)
- Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research,Institutionen för medicin, avdelningen för invärtesmedicin,Institute of Medicine, Department of Internal Medicine
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Murray, Anna (author)
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de Jong, Frank H (author)
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Spector, Tim D (author)
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Wallaschofski, Henri (author)
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(creator_code:org_t)
- 2011-04-14
- 2011
- English.
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In: PLoS genetics. - : Public Library of Science (PLoS). - 1553-7404 .- 1553-7390. ; 7:4
- Related links:
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https://doi.org/10.1...
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https://gup.ub.gu.se...
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Abstract
Subject headings
Close
- Dehydroepiandrosterone sulphate (DHEAS) is the most abundant circulating steroid secreted by adrenal glands--yet its function is unknown. Its serum concentration declines significantly with increasing age, which has led to speculation that a relative DHEAS deficiency may contribute to the development of common age-related diseases or diminished longevity. We conducted a meta-analysis of genome-wide association data with 14,846 individuals and identified eight independent common SNPs associated with serum DHEAS concentrations. Genes at or near the identified loci include ZKSCAN5 (rs11761528; p = 3.15 × 10(-36)), SULT2A1 (rs2637125; p = 2.61 × 10(-19)), ARPC1A (rs740160; p = 1.56 × 10(-16)), TRIM4 (rs17277546; p = 4.50 × 10(-11)), BMF (rs7181230; p = 5.44 × 10(-11)), HHEX (rs2497306; p = 4.64 × 10(-9)), BCL2L11 (rs6738028; p = 1.72 × 10(-8)), and CYP2C9 (rs2185570; p = 2.29 × 10(-8)). These genes are associated with type 2 diabetes, lymphoma, actin filament assembly, drug and xenobiotic metabolism, and zinc finger proteins. Several SNPs were associated with changes in gene expression levels, and the related genes are connected to biological pathways linking DHEAS with ageing. This study provides much needed insight into the function of DHEAS.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Keyword
- Actin-Related Protein 2-3 Complex
- genetics
- metabolism
- Adaptor Proteins
- Signal Transducing
- genetics
- metabolism
- Adult
- Aged
- Aging
- blood
- genetics
- Apoptosis Regulatory Proteins
- genetics
- metabolism
- Aryl Hydrocarbon Hydroxylases
- genetics
- metabolism
- Dehydroepiandrosterone Sulfate
- blood
- European Continental Ancestry Group
- genetics
- Female
- Gene Expression
- Genome-Wide Association Study
- Homeodomain Proteins
- genetics
- metabolism
- Humans
- Kruppel-Like Transcription Factors
- genetics
- metabolism
- Linkage Disequilibrium
- Liver
- metabolism
- Male
- Membrane Proteins
- genetics
- metabolism
- Middle Aged
- Polymorphism
- Single Nucleotide
- Proto-Oncogene Proteins
- genetics
- metabolism
- Sulfotransferases
- genetics
- metabolism
- Transcription Factors
- genetics
- metabolism
- Young Adult
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Zhai, Guangju
-
Teumer, Alexande ...
-
Stolk, Lisette
-
Perry, John R B
-
Vandenput, Liesb ...
-
Coviello, Andrea ...
-
show more...
-
Koster, Annemari ...
-
Bell, Jordana T
-
Bhasin, Shalende ...
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Eriksson, Joel
-
Eriksson, Anna-L ...
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Ernst, Florian
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Ferrucci, Luigi
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Frayling, Timoth ...
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Glass, Daniel
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Grundberg, Elin
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Haring, Robin
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Hedman, Asa K
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Hofman, Albert
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Kiel, Douglas P
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Kroemer, Heyo K
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Liu, Yongmei
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Lunetta, Kathryn ...
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Maggio, Marcello
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Lorentzon, Matti ...
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Mangino, Massimo
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Melzer, David
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Miljkovic, Iva
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Nica, Alexandra
-
Penninx, Brenda ...
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Vasan, Ramachand ...
-
Rivadeneira, Fer ...
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Small, Kerrin S
-
Soranzo, Nicole
-
Uitterlinden, An ...
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Völzke, Henry
-
Wilson, Scott G
-
Xi, Li
-
Zhuang, Wei Vivi ...
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Harris, Tamara B
-
Murabito, Joanne ...
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Ohlsson, Claes, ...
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Murray, Anna
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de Jong, Frank H
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Spector, Tim D
-
Wallaschofski, H ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
- Articles in the publication
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PLoS genetics
- By the university
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University of Gothenburg
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Uppsala University