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Changes in p14(ARF)...
Changes in p14(ARF) do not play a primary role in human chondrosarcoma tissues.
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- Asp, Julia, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för laboratoriemedicin, Avdelningen för klinisk kemi/transfusionsmedicin,Institute of Laboratory Medicine, Dept of Clinical Chemistry/Transfusion Medicine
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- Brantsing, Camilla (author)
- Gothenburg University,Göteborgs universitet,Institutionen för laboratoriemedicin, Avdelningen för klinisk kemi/transfusionsmedicin,Institute of Laboratory Medicine, Dept of Clinical Chemistry/Transfusion Medicine
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Benassi, M S (author)
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- Inerot, Sven, 1948 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för de kirurgiska disciplinerna, Avdelningen för ortopedi,Institute of Surgical Sciences, Department of Orthopaedics
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Sangiorgi, L (author)
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Picci, P (author)
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- Lindahl, Anders, 1954 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för laboratoriemedicin, Avdelningen för klinisk kemi/transfusionsmedicin,Institute of Laboratory Medicine, Dept of Clinical Chemistry/Transfusion Medicine
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(creator_code:org_t)
- 2001
- 2001
- English.
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In: International journal of cancer. Journal international du cancer. - 0020-7136. ; 93:5, s. 703-5
- Related links:
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https://gup.ub.gu.se...
Abstract
Subject headings
Close
- The locus encoding the tumor suppressor p16 has been found to code for a second, different protein. This protein, p14(ARF), has been shown to protect p53 from degradation. Like p16, its gene is often altered in different cancers. In this study, the first unique exon, exon 1 beta, of p14(ARF), has been studied in 22 chondrosarcoma tissues using polymerase chain reaction, DNA sequencing and methylation-specific polymerase chain reaction. One chondrosarcoma was found to have exon 1 beta homozygously deleted, but neither mutations nor methylations were found in any of the chondrosarcomas. This indicates that genetic changes of p14(ARF) are a rare event in chondrosarcoma.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Klinisk laboratoriemedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Clinical Laboratory Medicine (hsv//eng)
Keyword
- Base Sequence
- Bone Neoplasms
- genetics
- metabolism
- Chondrosarcoma
- genetics
- metabolism
- DNA
- Neoplasm
- analysis
- Exons
- genetics
- Humans
- Molecular Sequence Data
- Proteins
- genetics
- metabolism
- Sequence Homology
- Nucleic Acid
- Tumor Suppressor Protein p14ARF
Publication and Content Type
- ref (subject category)
- art (subject category)
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Asp, Julia, 1973
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Brantsing, Camil ...
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Benassi, M S
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Inerot, Sven, 19 ...
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Sangiorgi, L
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Picci, P
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show more...
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Lindahl, Anders, ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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University of Gothenburg