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Changes in p14(ARF)...
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Asp, Julia,1973Gothenburg University,Göteborgs universitet,Institutionen för laboratoriemedicin, Avdelningen för klinisk kemi/transfusionsmedicin,Institute of Laboratory Medicine, Dept of Clinical Chemistry/Transfusion Medicine
(author)
Changes in p14(ARF) do not play a primary role in human chondrosarcoma tissues.
- Article/chapterEnglish2001
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LIBRIS-ID:oai:gup.ub.gu.se/170112
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https://gup.ub.gu.se/publication/170112URI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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The locus encoding the tumor suppressor p16 has been found to code for a second, different protein. This protein, p14(ARF), has been shown to protect p53 from degradation. Like p16, its gene is often altered in different cancers. In this study, the first unique exon, exon 1 beta, of p14(ARF), has been studied in 22 chondrosarcoma tissues using polymerase chain reaction, DNA sequencing and methylation-specific polymerase chain reaction. One chondrosarcoma was found to have exon 1 beta homozygously deleted, but neither mutations nor methylations were found in any of the chondrosarcomas. This indicates that genetic changes of p14(ARF) are a rare event in chondrosarcoma.
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Brantsing, CamillaGothenburg University,Göteborgs universitet,Institutionen för laboratoriemedicin, Avdelningen för klinisk kemi/transfusionsmedicin,Institute of Laboratory Medicine, Dept of Clinical Chemistry/Transfusion Medicine(Swepub:gu)xbranc
(author)
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Benassi, M S
(author)
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Inerot, Sven,1948Gothenburg University,Göteborgs universitet,Institutionen för de kirurgiska disciplinerna, Avdelningen för ortopedi,Institute of Surgical Sciences, Department of Orthopaedics(Swepub:gu)xinesv
(author)
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Sangiorgi, L
(author)
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Picci, P
(author)
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Lindahl, Anders,1954Gothenburg University,Göteborgs universitet,Institutionen för laboratoriemedicin, Avdelningen för klinisk kemi/transfusionsmedicin,Institute of Laboratory Medicine, Dept of Clinical Chemistry/Transfusion Medicine(Swepub:gu)xlandy
(author)
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Göteborgs universitetInstitutionen för laboratoriemedicin, Avdelningen för klinisk kemi/transfusionsmedicin
(creator_code:org_t)
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In:International journal of cancer. Journal international du cancer93:5, s. 703-50020-7136
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Picci, P
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University of Gothenburg