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Transcriptome signa...
Transcriptome signatures in Helicobacter pylori-infected mucosa identifies acidic mammalian chitinase loss as a corpus atrophy marker
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- Nookaew, Intawat, 1977 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Thorell, Kaisa, 1983 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology,University of Gothenburg,Chalmers tekniska högskola,Chalmers University of Technology
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- Worah, Kuntal, 1982 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology,Chalmers tekniska högskola,Chalmers University of Technology,University of Gothenburg
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- Wang, Shugui (author)
- Karolinska universitetssjukhuset,Karolinska University Hospital,National Cancer Centre, Singapore
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- Hibberd, Martin Lloyd (author)
- Genome Institute of Singapore
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- Sjövall, Henrik, 1954 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,University of Gothenburg
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- Pettersson, Sven (author)
- Karolinska Institutet
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- Nielsen, Jens B, 1962 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Lundin, Samuel B, 1970 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology,University of Gothenburg
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(creator_code:org_t)
- 2013-10-11
- 2013
- English.
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In: BMC Medical Genomics. - : Springer Science and Business Media LLC. - 1755-8794. ; 6:41
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Abstract
Subject headings
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- The majority of gastric cancer cases are believed to be caused by chronic infection with the bacterium Helicobacter pylori, and atrophic corpus gastritis is a predisposing condition to gastric cancer development. We aimed to increase understanding of the molecular details of atrophy by performing a global transcriptome analysis of stomach tissue. Biopsies from patients with different stages of H. pylori infection were taken from both the antrum and corpus mucosa and analyzed on microarrays. The stages included patients without current H. pylori infection, H. pylori-infected without corpus atrophy and patients with current or past H. pylori-infection with corpus-predominant atrophic gastritis. Using clustering and integrated analysis, we found firm evidence for antralization of the corpus mucosa of atrophy patients. This antralization harbored gain of gastrin expression, as well as loss of expression of corpus-related genes, such as genes associated with acid production, energy metabolism and blood clotting. The analyses provided detailed molecular evidence for simultaneous intestinal metaplasia (IM) and spasmolytic polypeptide expressing metaplasia (SPEM) in atrophic corpus tissue. Finally, acidic mammalian chitinase, a chitin-degrading enzyme produced by chief cells, was shown to be strongly down-regulated in corpus atrophy. Transcriptome analysis revealed several gene groups which are related to development of corpus atrophy, some of which were increased also in H. pylori-infected non-atrophic patients. Furthermore, loss of acidic chitinase expression is a promising marker for corpus atrophy.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Keyword
- Corpus gastritis
- Gastric cancer
- Integrated analysis
- Acidic mammalian chitinase
- Integrated analysis
Publication and Content Type
- ref (subject category)
- art (subject category)
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Nookaew, Intawat ...
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Thorell, Kaisa, ...
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Worah, Kuntal, 1 ...
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Wang, Shugui
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Hibberd, Martin ...
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Sjövall, Henrik, ...
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Pettersson, Sven
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Nielsen, Jens B, ...
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Lundin, Samuel B ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
- Articles in the publication
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BMC Medical Geno ...
- By the university
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University of Gothenburg
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Chalmers University of Technology
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Karolinska Institutet