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Conversion from cli...
Conversion from clinically isolated syndrome to multiple sclerosis: A large multicentre study
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Kuhle, J. (author)
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Disanto, G. (author)
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Dobson, R. (author)
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show more...
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Adiutori, R. (author)
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Bianchi, L. (author)
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Topping, J. (author)
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Bestwick, J. P. (author)
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Meier, U. C. (author)
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- Marta, M. (author)
- Karolinska Institutet
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Dalla Costa, G. (author)
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Runia, T. (author)
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Evdoshenko, E. (author)
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Lazareva, N. (author)
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Thouvenot, E. (author)
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Iaffaldano, P. (author)
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Direnzo, V. (author)
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Khademi, M. (author)
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- Piehl, F. (author)
- Karolinska Institutet
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Comabella, M. (author)
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Sombekke, M. (author)
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Killestein, J. (author)
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Hegen, H. (author)
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Rauch, S. (author)
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D'Alfonso, S. (author)
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Alvarez-Cermeno, J. C. (author)
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Kleinova, P. (author)
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Horakova, D. (author)
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Roesler, R. (author)
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Lauda, F. (author)
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Llufriu, S. (author)
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Avsar, T. (author)
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Uygunoglu, U. (author)
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Altintas, A. (author)
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Saip, S. (author)
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Menge, T. (author)
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Rajda, C. (author)
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Bergamaschi, R. (author)
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Moll, N. (author)
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Khalil, M. (author)
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Marignier, R. (author)
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Dujmovic, I. (author)
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Larsson, H. (author)
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- Malmeström, Clas, 1965 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology
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Scarpini, E. (author)
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Fenoglio, C. (author)
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Wergeland, S. (author)
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Laroni, A. (author)
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Annibali, V. (author)
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Romano, S. (author)
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Martinez, A. D. (author)
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Carra, A. (author)
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Salvetti, M. (author)
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Uccelli, A. (author)
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- Torkildsen, O. (author)
- Karolinska Institutet
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Myhr, K. M. (author)
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Galimberti, D. (author)
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Rejdak, K. (author)
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- Lycke, Jan, 1956 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology
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Frederiksen, J. L. (author)
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Drulovic, J. (author)
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Confavreux, C. (author)
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Brassat, D. (author)
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Enzinger, C. (author)
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Fuchs, S. (author)
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Bosca, I. (author)
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Pelletier, J. (author)
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Picard, C. (author)
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Colombo, E. (author)
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Franciotta, D. (author)
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Derfuss, T. (author)
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Lindberg, R. L. P. (author)
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Yaldizli, O. (author)
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Vecsei, L. (author)
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Kieseier, B. C. (author)
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Hartung, H. P. (author)
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Villoslada, P. (author)
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Siva, A. (author)
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Saiz, A. (author)
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Tumani, H. (author)
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Havrdova, E. (author)
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Villar, L. M. (author)
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Leone, M. (author)
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Barizzone, N. (author)
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Deisenhammer, F. (author)
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Teunissen, C. (author)
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Montalban, X. (author)
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Tintore, M. (author)
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Olsson, T. (author)
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Trojano, M. (author)
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Lehmann, S. (author)
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Castelnovo, G. (author)
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Lapin, S. (author)
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Hintzen, R. (author)
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Kappos, L. (author)
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Furlan, R. (author)
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Martinelli, V. (author)
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Comi, G. (author)
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Ramagopalan, S. V. (author)
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Giovannoni, G. (author)
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(creator_code:org_t)
- 2015-02-13
- 2015
- English.
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In: Multiple Sclerosis Journal. - : SAGE Publications. - 1352-4585 .- 1477-0970. ; 21:8, s. 1013-1024
- Related links:
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https://gup.ub.gu.se...
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show more...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Subject headings
Close
- Background and objective: We explored which clinical and biochemical variables predict conversion from clinically isolated syndrome (CIS) to clinically definite multiple sclerosis (CDMS) in a large international cohort. Methods: Thirty-three centres provided serum samples from 1047 CIS cases with at least two years' follow-up. Age, sex, clinical presentation, T2-hyperintense lesions, cerebrospinal fluid (CSF) oligoclonal bands (OCBs), CSF IgG index, CSF cell count, serum 25-hydroxyvitamin D3 (25-OH-D), cotinine and IgG titres against Epstein-Barr nuclear antigen 1 (EBNA-1) and cytomegalovirus were tested for association with risk of CDMS. Results: At median follow-up of 4.31 years, 623 CIS cases converted to CDMS. Predictors of conversion in multivariable analyses were OCB (HR = 2.18, 95% CI = 1.71-2.77, p < 0.001), number of T2 lesions (two to nine lesions vs 0/1 lesions: HR = 1.97, 95% CI = 1.52-2.55, p < 0.001; >9 lesions vs 0/1 lesions: HR = 2.74, 95% CI = 2.04-3.68, p < 0.001) and age at CIS (HR per year inversely increase = 0.98, 95% CI = 0.98-0.99, p < 0.001). Lower 25-OH-D levels were associated with CDMS in univariable analysis, but this was attenuated in the multivariable model. OCB positivity was associated with higher EBNA-1 IgG titres. Conclusions: We validated MRI lesion load, OCB and age at CIS as the strongest independent predictors of conversion to CDMS in this multicentre setting. A role for vitamin D is suggested but requires further investigation.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Clinically definite multiple sclerosis (CDMS)
- clinically isolated syndrome (CIS)
- Epstein-Barr nuclear
- VITAMIN-D
- OLIGOCLONAL BANDS
- RISK
- ONSET
- PROGRESSION
- DIAGNOSIS
- LESIONS
- SYSTEM
- MRI
- Clinical Neurology
- Neurosciences
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Kuhle, J.
-
Disanto, G.
-
Dobson, R.
-
Adiutori, R.
-
Bianchi, L.
-
Topping, J.
-
show more...
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Bestwick, J. P.
-
Meier, U. C.
-
Marta, M.
-
Dalla Costa, G.
-
Runia, T.
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Evdoshenko, E.
-
Lazareva, N.
-
Thouvenot, E.
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Iaffaldano, P.
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Direnzo, V.
-
Khademi, M.
-
Piehl, F.
-
Comabella, M.
-
Sombekke, M.
-
Killestein, J.
-
Hegen, H.
-
Rauch, S.
-
D'Alfonso, S.
-
Alvarez-Cermeno, ...
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Kleinova, P.
-
Horakova, D.
-
Roesler, R.
-
Lauda, F.
-
Llufriu, S.
-
Avsar, T.
-
Uygunoglu, U.
-
Altintas, A.
-
Saip, S.
-
Menge, T.
-
Rajda, C.
-
Bergamaschi, R.
-
Moll, N.
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Khalil, M.
-
Marignier, R.
-
Dujmovic, I.
-
Larsson, H.
-
Malmeström, Clas ...
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Scarpini, E.
-
Fenoglio, C.
-
Wergeland, S.
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Laroni, A.
-
Annibali, V.
-
Romano, S.
-
Martinez, A. D.
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Carra, A.
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Salvetti, M.
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Uccelli, A.
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Torkildsen, O.
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Myhr, K. M.
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Galimberti, D.
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Rejdak, K.
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Lycke, Jan, 1956
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Frederiksen, J. ...
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Drulovic, J.
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Confavreux, C.
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Brassat, D.
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Enzinger, C.
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Fuchs, S.
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Bosca, I.
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Pelletier, J.
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Picard, C.
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Colombo, E.
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Franciotta, D.
-
Derfuss, T.
-
Lindberg, R. L. ...
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Yaldizli, O.
-
Vecsei, L.
-
Kieseier, B. C.
-
Hartung, H. P.
-
Villoslada, P.
-
Siva, A.
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Saiz, A.
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Tumani, H.
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Havrdova, E.
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Villar, L. M.
-
Leone, M.
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Barizzone, N.
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Deisenhammer, F.
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Teunissen, C.
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Montalban, X.
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Tintore, M.
-
Olsson, T.
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Trojano, M.
-
Lehmann, S.
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Castelnovo, G.
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Lapin, S.
-
Hintzen, R.
-
Kappos, L.
-
Furlan, R.
-
Martinelli, V.
-
Comi, G.
-
Ramagopalan, S. ...
-
Giovannoni, G.
-
show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Multiple Scleros ...
- By the university
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University of Gothenburg
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Karolinska Institutet