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Evidence for geneti...
Evidence for genetic heterogeneity between clinical subtypes of bipolar disorder
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Charney, A. W. (author)
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Ruderfer, D. M. (author)
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Stahl, E. A. (author)
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show more...
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- Moran, J. L. (author)
- Karolinska Institutet
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Chambert, K. (author)
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Belliveau, R. A. (author)
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Forty, L. (author)
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Gordon-Smith, K. (author)
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Di Florio, A. (author)
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Lee, P. H. (author)
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Bromet, E. J. (author)
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Buckley, P. F. (author)
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Escamilla, M. A. (author)
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Fanous, A. H. (author)
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Fochtmann, L. J. (author)
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Lehrer, D. S. (author)
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Malaspina, D. (author)
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- Marder, S. R. (author)
- Karolinska Institutet
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Morley, C. P. (author)
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Nicolini, H. (author)
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Perkins, D. O. (author)
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Rakofsky, J. J. (author)
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Rapaport, M. H. (author)
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- Medeiros, H. (author)
- Karolinska Institutet
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Sobell, J. L. (author)
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Green, E. K. (author)
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- Backlund, L. (author)
- Karolinska Institutet
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- Bergen, S. E. (author)
- Karolinska Institutet
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- Jureus, A. (author)
- Karolinska Institutet
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Schalling, M. (author)
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- Lichtenstein, P. (author)
- Karolinska Institutet
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Roussos, P. (author)
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Knowles, J. A. (author)
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Jones, I. (author)
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Jones, L. A. (author)
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Hultman, C. M. (author)
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Perlis, R. H. (author)
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Purcell, S. M. (author)
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McCarroll, S. A. (author)
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Pato, C. N. (author)
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Pato, M. T. (author)
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Craddock, N. (author)
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- Landén, Mikael, 1966 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology
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Smoller, J. W. (author)
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Sklar, P. (author)
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(creator_code:org_t)
- 2017-01-10
- 2017
- English.
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In: Translational Psychiatry. - : Springer Science and Business Media LLC. - 2158-3188. ; 7:1
- Related links:
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https://www.nature.c...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
Close
- We performed a genome-wide association study of 6447 bipolar disorder (BD) cases and 12 639 controls from the International Cohort Collection for Bipolar Disorder (ICCBD). Meta-analysis was performed with prior results from the Psychiatric Genomics Consortium Bipolar Disorder Working Group for a combined sample of 13 902 cases and 19 279 controls. We identified eight genome-wide significant, associated regions, including a novel associated region on chromosome 10 (rs10884920; P = 3.28 x 10(-8)) that includes the brain-enriched cytoskeleton protein adducin 3 (ADD3), a non-coding RNA, and a neuropeptide-specific aminopeptidase P (XPNPEP1). Our large sample size allowed us to test the heritability and genetic correlation of BD subtypes and investigate their genetic overlap with schizophrenia and major depressive disorder. We found a significant difference in heritability of the two most common forms of BD (BD I SNP-h(2) = 0.35; BD II SNP-h(2) = 0.25; P = 0.02). The genetic correlation between BD I and BD II was 0.78, whereas the genetic correlation was 0.97 when BD cohorts containing both types were compared. In addition, we demonstrated a significantly greater load of polygenic risk alleles for schizophrenia and BD in patients with BD I compared with patients with BD II, and a greater load of schizophrenia risk alleles in patients with the bipolar type of schizoaffective disorder compared with patients with either BD I or BD II. These results point to a partial difference in the genetic architecture of BD subtypes as currently defined.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Keyword
- genome-wide association
- spectrum disorder
- ii disorder
- risk loci
- schizophrenia
- family
- depression
- unipolar
- illness
- susceptibility
- Psychiatry
- rshon es
- 1982
- archives of general psychiatry
- v39
- p1157
- guffin p
- 1991
- archives of general psychiatry
- v48
- p764
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Charney, A. W.
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Ruderfer, D. M.
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Stahl, E. A.
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Moran, J. L.
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Chambert, K.
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Belliveau, R. A.
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show more...
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Forty, L.
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Gordon-Smith, K.
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Di Florio, A.
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Lee, P. H.
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Bromet, E. J.
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Buckley, P. F.
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Escamilla, M. A.
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Fanous, A. H.
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Fochtmann, L. J.
-
Lehrer, D. S.
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Malaspina, D.
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Marder, S. R.
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Morley, C. P.
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Nicolini, H.
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Perkins, D. O.
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Rakofsky, J. J.
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Rapaport, M. H.
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Medeiros, H.
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Sobell, J. L.
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Green, E. K.
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Backlund, L.
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Bergen, S. E.
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Jureus, A.
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Schalling, M.
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Lichtenstein, P.
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Roussos, P.
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Knowles, J. A.
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Jones, I.
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Jones, L. A.
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Hultman, C. M.
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Perlis, R. H.
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Purcell, S. M.
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McCarroll, S. A.
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Pato, C. N.
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Pato, M. T.
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Craddock, N.
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Landén, Mikael, ...
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Smoller, J. W.
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Sklar, P.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Psychiatry
- Articles in the publication
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Translational Ps ...
- By the university
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University of Gothenburg
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Karolinska Institutet