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Detailed phenotypin...
Detailed phenotyping of posterior vs. anterior circulation ischemic stroke: a multi-center MRI study
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- Frid, Petrea (author)
- Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Stroke Imaging Research group,Forskargrupper vid Lunds universitet,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups,Skåne University Hospital,University of Maryland School of Medicine
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- Drake, Mattias (author)
- Lund University,Lunds universitet,Stroke Imaging Research group,Forskargrupper vid Lunds universitet,Lund University Research Groups,Skåne University Hospital,Massachusetts Institute of Technology,German Center for Neurodegenerative Diseases (DZNE), Bonn,Massachusetts General Hospital
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- Giese, A. K. (author)
- Massachusetts General Hospital,Harvard Medical School,Broad Institute
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- Wasselius, J. (author)
- Lund University,Lunds universitet,Neuroradiologi,Forskargrupper vid Lunds universitet,Stroke Imaging Research group,Neuroradiology,Lund University Research Groups,Skåne University Hospital,Baltimore Veterans Administration Medical Center,University of Maryland School of Medicine
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Schirmer, M. D. (author)
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- Donahue, K. L. (author)
- Massachusetts General Hospital,Harvard Medical School
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- Cloonan, L. (author)
- Harvard Medical School,Massachusetts General Hospital
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- Irie, R. (author)
- Massachusetts General Hospital,Harvard Medical School
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- Bouts, Mjrj (author)
- Massachusetts General Hospital,Harvard Medical School,University of Cincinnati College of Medicine
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- McIntosh, E. C. (author)
- Harvard Medical School,Massachusetts General Hospital
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- Mocking, S. J. T. (author)
- Harvard Medical School,Massachusetts General Hospital
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- Dalca, A. V. (author)
- Massachusetts Institute of Technology,Massachusetts General Hospital
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- Sridharan, R. (author)
- Massachusetts Institute of Technology,Harvard Medical School,Massachusetts General Hospital
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- Xu, H. (author)
- University of Maryland School of Medicine
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- Giralt-Steinhauer, E. (author)
- Autonomous University of Barcelona
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- Holmegaard, Lukas (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience,Sahlgrenska Academy,Sahlgrenska University Hospital
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- Jood, Katarina, 1966 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience,Sahlgrenska University Hospital,Sahlgrenska Academy
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- Roquer, J. (author)
- Autonomous University of Barcelona
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Cole, J. W. (author)
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McArdle, P. F. (author)
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- Petersson, J. (author)
- Lund University,Lunds universitet,Stroke policy och kvalitetsregisterforskning,Forskargrupper vid Lunds universitet,Stroke policy and quality register research,Lund University Research Groups,Skåne University Hospital
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- Jimenez-Conde, J. (author)
- Autonomous University of Barcelona
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- Jern, Christina, 1962 (author)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för biomedicin,Institute of Biomedicine
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Kissela, B. M. (author)
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- Kleindorfer, D. O. (author)
- University of Cincinnati College of Medicine
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- Lemmens, R. (author)
- Catholic University of Leuven,University Hospitals Leuven,University of Miami
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- Meschia, J. F. (author)
- Mayo Clinic Florida
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- Rundek, T. (author)
- University of Miami
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Sacco, R. L. (author)
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- Schmidt, R. (author)
- Medical University of Graz
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- Sharma, P. (author)
- Royal Holloway University of London
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- Slowik, A. (author)
- Jagiellonian University
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- Thijs, V. (author)
- Austin Health
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- Woo, D. (author)
- University of Cincinnati College of Medicine
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- Worrall, B. B. (author)
- University of Virginia
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- Kittner, S. J. (author)
- University of Maryland School of Medicine,Baltimore Veterans Administration Medical Center
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- Mitchell, B. D. (author)
- University of Maryland School of Medicine,Baltimore Veterans Administration Medical Center
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Petersson, J. (author)
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- Rosand, J. (author)
- Harvard Medical School,Massachusetts General Hospital,Broad Institute
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- Golland, P. (author)
- Massachusetts Institute of Technology
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- Wu, O. (author)
- Massachusetts General Hospital,Harvard Medical School
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Rost, N. S. (author)
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- Lindgren, A. (author)
- Lund University,Lunds universitet,Klinisk strokeforskning,Forskargrupper vid Lunds universitet,Clinical Stroke Research Group,Lund University Research Groups,Skåne University Hospital
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- 2019-11-11
- 2020
- English.
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In: Journal of Neurology. - : Springer Science and Business Media LLC. - 0340-5354 .- 1432-1459. ; 267, s. 649-658
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http://dx.doi.org/10... (free)
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Objective Posterior circulation ischemic stroke (PCiS) constitutes 20-30% of ischemic stroke cases. Detailed information about differences between PCiS and anterior circulation ischemic stroke (ACiS) remains scarce. Such information might guide clinical decision making and prevention strategies. We studied risk factors and ischemic stroke subtypes in PCiS vs. ACiS and lesion location on magnetic resonance imaging (MRI) in PCiS. Methods Out of 3,301 MRIs from 12 sites in the National Institute of Neurological Disorders and Stroke (NINDS) Stroke Genetics Network (SiGN), we included 2,381 cases with acute DWI lesions. The definition of ACiS or PCiS was based on lesion location. We compared the groups using Chi-squared and logistic regression. Results PCiS occurred in 718 (30%) patients and ACiS in 1663 (70%). Diabetes and male sex were more common in PCiS vs. ACiS (diabetes 27% vs. 23%, p < 0.05; male sex 68% vs. 58%, p < 0.001). Both were independently associated with PCiS (diabetes, OR = 1.29; 95% CI 1.04-1.61; male sex, OR = 1.46; 95% CI 1.21-1.78). ACiS more commonly had large artery atherosclerosis (25% vs. 20%, p < 0.01) and cardioembolic mechanisms (17% vs. 11%, p < 0.001) compared to PCiS. Small artery occlusion was more common in PCiS vs. ACiS (20% vs. 14%, p < 0.001). Small artery occlusion accounted for 47% of solitary brainstem infarctions. Conclusion Ischemic stroke subtypes differ between the two phenotypes. Diabetes and male sex have a stronger association with PCiS than ACiS. Definitive MRI-based PCiS diagnosis aids etiological investigation and contributes additional insights into specific risk factors and mechanisms of injury in PCiS.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- Stroke
- Posterior circulation brain infarction
- Risk factors
- Magnetic
- resonance imaging
- Phenotyping
- risk-factors
- causative classification
- consecutive patients
- cerebral
- infarction
- subtypes
- registry
- disease
- glucose
- sign
- Neurosciences & Neurology
- Magnetic resonance imaging
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Frid, Petrea
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Drake, Mattias
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Giese, A. K.
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Wasselius, J.
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Schirmer, M. D.
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Donahue, K. L.
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show more...
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Cloonan, L.
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Irie, R.
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Bouts, Mjrj
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McIntosh, E. C.
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Mocking, S. J. T ...
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Dalca, A. V.
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Sridharan, R.
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Xu, H.
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Giralt-Steinhaue ...
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Holmegaard, Luka ...
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Jood, Katarina, ...
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Roquer, J.
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Cole, J. W.
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McArdle, P. F.
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Petersson, J.
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Jimenez-Conde, J ...
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Jern, Christina, ...
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Kissela, B. M.
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Kleindorfer, D. ...
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Lemmens, R.
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Meschia, J. F.
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Rundek, T.
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Sacco, R. L.
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Schmidt, R.
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Sharma, P.
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Slowik, A.
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Thijs, V.
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Woo, D.
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Worrall, B. B.
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Kittner, S. J.
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Mitchell, B. D.
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Rosand, J.
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Golland, P.
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Wu, O.
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Rost, N. S.
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Lindgren, A.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
- Articles in the publication
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Journal of Neuro ...
- By the university
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University of Gothenburg
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Lund University