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Replication study o...
Replication study of plasma proteins relating to Alzheimer's pathology.
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- Shi, Liu (author)
- Department of Psychiatry, University of Oxford, Oxford, UK
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Winchester, Laura M (author)
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Westwood, Sarah (author)
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Baird, Alison L (author)
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Anand, Sneha N (author)
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Buckley, Noel J (author)
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Hye, Abdul (author)
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Ashton, Nicholas J (author)
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Bos, Isabelle (author)
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Vos, Stephanie J B (author)
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Kate, Mara Ten (author)
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Scheltens, Philip (author)
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Teunissen, Charlotte E (author)
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Vandenberghe, Rik (author)
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Gabel, Silvy (author)
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Meersmans, Karen (author)
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Engelborghs, Sebastiaan (author)
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De Roeck, Ellen E (author)
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Sleegers, Kristel (author)
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Frisoni, Giovanni B (author)
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Blin, Olivier (author)
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Richardson, Jill C (author)
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Bordet, Régis (author)
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Molinuevo, José L (author)
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Rami, Lorena (author)
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Wallin, Anders (author)
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- Kettunen, Petronella (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Tsolaki, Magda (author)
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Verhey, Frans (author)
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Lléo, Alberto (author)
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Sala, Isabel (author)
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Popp, Julius (author)
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Peyratout, Gwendoline (author)
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Martinez-Lage, Pablo (author)
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Tainta, Mikel (author)
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Johannsen, Peter (author)
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- Freund-Levi, Yvonne, 1956- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Maurice Wohl Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, Kings College London, London, UK; Karolinska Institutet Center for Alzheimer Research, Division of Clinical Geriatrics, Stockholm, Sweden; Department of Neurobiology, Caring Sciences and Society (NVS), Stockholm, Sweden
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Frölich, Lutz (author)
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Dobricic, Valerija (author)
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Legido-Quigley, Cristina (author)
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Barkhof, Frederik (author)
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Andreasson, Ulf (author)
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- Blennow, Kaj, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Streffer, Johannes (author)
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Lill, Christina M (author)
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Bertram, Lars (author)
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Visser, Pieter Jelle (author)
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Kolb, Hartmuth C (author)
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Narayan, Vaibhav A (author)
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Lovestone, Simon (author)
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- Nevado-Holgado, Alejo J (author)
- Department of Psychiatry, University of Oxford, Oxford, UK
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(creator_code:org_t)
- 2021-03-31
- 2021
- English.
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In: Alzheimer's & dementia : the journal of the Alzheimer's Association. - : Wiley. - 1552-5279 .- 1552-5260. ; 17:9, s. 1452-1464
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https://doi.org/10.1...
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Abstract
Subject headings
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- This study sought to discover and replicate plasma proteomic biomarkers relating to Alzheimer's disease (AD) including both the "ATN" (amyloid/tau/neurodegeneration) diagnostic framework and clinical diagnosis.Plasma proteins from 972 subjects (372 controls, 409 mild cognitive impairment [MCI], and 191 AD) were measured using both SOMAscan and targeted assays, including 4001 and 25 proteins, respectively.Protein co-expression network analysis of SOMAscan data revealed the relation between proteins and "N" varied across different neurodegeneration markers, indicating that the ATN variants are not interchangeable. Using hub proteins, age, and apolipoprotein E ε4 genotype discriminated AD from controls with an area under the curve (AUC) of 0.81 and MCI convertors from non-convertors with an AUC of 0.74. Targeted assays replicated the relation of four proteins with the ATN framework and clinical diagnosis.Our study suggests that blood proteins can predict the presence of AD pathology as measured in the ATN framework as well as clinical diagnosis.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Klinisk laboratoriemedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Clinical Laboratory Medicine (hsv//eng)
Keyword
- ATN framework
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Shi, Liu
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Winchester, Laur ...
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Westwood, Sarah
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Baird, Alison L
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Anand, Sneha N
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Buckley, Noel J
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show more...
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Hye, Abdul
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Ashton, Nicholas ...
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Bos, Isabelle
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Vos, Stephanie J ...
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Kate, Mara Ten
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Scheltens, Phili ...
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Teunissen, Charl ...
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Vandenberghe, Ri ...
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Gabel, Silvy
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Meersmans, Karen
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Engelborghs, Seb ...
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De Roeck, Ellen ...
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Sleegers, Kriste ...
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Frisoni, Giovann ...
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Blin, Olivier
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Richardson, Jill ...
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Bordet, Régis
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Molinuevo, José ...
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Rami, Lorena
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Wallin, Anders
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Kettunen, Petron ...
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Tsolaki, Magda
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Verhey, Frans
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Lléo, Alberto
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Sala, Isabel
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Popp, Julius
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Peyratout, Gwend ...
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Martinez-Lage, P ...
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Tainta, Mikel
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Johannsen, Peter
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Freund-Levi, Yvo ...
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Frölich, Lutz
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Dobricic, Valeri ...
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Legido-Quigley, ...
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Barkhof, Frederi ...
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Andreasson, Ulf
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Blennow, Kaj, 19 ...
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Zetterberg, Henr ...
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Streffer, Johann ...
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Lill, Christina ...
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Bertram, Lars
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Visser, Pieter J ...
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Kolb, Hartmuth C
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Narayan, Vaibhav ...
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Lovestone, Simon
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Nevado-Holgado, ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Biochemistry and ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Clinical Laborat ...
- Articles in the publication
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Alzheimer's & de ...
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Alzheimer's & De ...
- By the university
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University of Gothenburg
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Örebro University
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Karolinska Institutet