Progression of white matter hyperintensities and incidence of new lacunes over a 3-year period: the Leukoaraiosis and Disability study.

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Progression of white matter hyperintensities and incidence of new lacunes over a 3-year period: the Leukoaraiosis and Disability study.

Gouw, Alida A (författare)

van der Flier, Wiesje M (författare)

Fazekas, Franz (författare)

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van Straaten, Elisabeth C W (författare)

Pantoni, Leonardo (författare)

Poggesi, Anna (författare)

Inzitari, Domenico (författare)

Erkinjuntti, Timo (författare)

Wahlund, Lars O (författare): Karolinska Institutet

Waldemar, Gunhild (författare)

Schmidt, Reinhold (författare)

Scheltens, Philip (författare)

Barkhof, Frederik (författare)

Wallin, Anders, 1950 (författare): Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry

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(creator_code:org_t)

2008
2008
Engelska.
Ingår i: Stroke; a journal of cerebral circulation. - 1524-4628. ; 39:5, s. 1414-20

Relaterad länk:: https://gup.ub.gu.se...; visa fler...; https://doi.org/10.1...; http://kipublication...; visa färre...

Tidskriftsartikel (refereegranskat)

Abstract Ämnesord

Stäng

BACKGROUND AND PURPOSE: We studied the natural course of white matter hyperintensities (WMH) and lacunes, the main MRI representatives of small vessel disease, over time and evaluated possible predictors for their development. METHODS: Baseline and repeat MRI (3-year follow-up) were collected within the multicenter, multinational Leukoaraiosis and Disability study (n=396). Baseline WMH were scored on MRI by the Fazekas scale and the Scheltens scale. WMH progression was assessed using the modified Rotterdam Progression scale (absence/presence of progression in 9 brain regions). Baseline and new lacunes were counted per region. WMH and lacunes at baseline and vascular risk factors were evaluated as predictors of WMH progression and new lacunes. RESULTS: WMH progressed (mean+/-SD=1.9+/-1.8) mostly in the subcortical white matter, where WMH was also most prevalent at baseline. The majority of new lacunes, which were found in 19% of the subjects (maximum=9), also appeared in the subcortical white matter, mainly of the frontal lobes, whereas most baseline lacunes were located in the basal ganglia. Baseline WMH and lacunes predicted both WMH progression and new lacunes. Furthermore, previous stroke, diabetes, and blood glucose were risk factors for WMH progression. Male sex, hypertension, systolic blood pressure, previous stroke, body mass index, high-density lipoprotein, and triglyceride levels were risk factors for new lacunes. CONCLUSIONS: WMH and lacunes progressed over time, predominantly in the subcortical white matter. Progression was observed especially in subjects with considerable WMH and lacunes at baseline. Moreover, the presence of vascular risk factors at baseline predicted WMH progression and new lacunes over a 3-year period.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)

Nyckelord

Aged
Aged
80 and over
Basal Ganglia
blood supply
pathology
physiopathology
Brain
blood supply
pathology
physiopathology
Brain Infarction
epidemiology
pathology
physiopathology
Brain Ischemia
epidemiology
pathology
physiopathology
Cardiovascular Diseases
epidemiology
Cerebral Arteries
pathology
physiopathology
Comorbidity
Disease Progression
Female
Follow-Up Studies
Frontal Lobe
blood supply
pathology
physiopathology
Humans
Hyperlipidemias
epidemiology
Incidence
Leukoaraiosis
epidemiology
pathology
physiopathology
Magnetic Resonance Imaging
Male
Nerve Fibers
Myelinated
pathology
Prevalence
Risk Factors
Time Factors

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Stroke; a journal of cerebral circulation (Sök värdpublikationen i LIBRIS)

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Av författaren/redakt...: Gouw, Alida A; van der Flier, W ...; Fazekas, Franz; van Straaten, El ...; Pantoni, Leonard ...; Poggesi, Anna; visa fler...; Inzitari, Domeni ...; Erkinjuntti, Tim ...; Wahlund, Lars O; Waldemar, Gunhil ...; Schmidt, Reinhol ...; Scheltens, Phili ...; Barkhof, Frederi ...; Wallin, Anders, ...; visa färre...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Psykiatri

Artiklar i publikationen: Stroke; a journa ...

Av lärosätet: Göteborgs universitet; Karolinska Institutet

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