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  • Li, QianShriners Hospitals for Children,University of South Florida,Farr Institute of Health Informatics Research,University of South Florida; Department of Sociology (author)

Plasma Metabolome and Circulating Vitamins Stratified Onset Age of an Initial Islet Autoantibody and Progression to Type 1 Diabetes : the TEDDY Study

  • Article/chapterEnglish2021

Publisher, publication year, extent ...

  • 2020-10-26
  • American Diabetes Association,2021
  • 11 s.

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:0ed9bab1-cae4-4269-a606-390f5f859231
  • https://lup.lub.lu.se/record/0ed9bab1-cae4-4269-a606-390f5f859231URI
  • https://doi.org/10.2337/db20-0696DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Children's plasma metabolome, especially lipidome reflects gene regulation and dietary exposures, heralding the development of islet autoantibodies (IA) and type 1 diabetes (T1D). The TEDDY study enrolled 8676 newborns by screening HLA-DR-DQ genotypes at six clinical centers in four countries; profiled metabolome and measured concentrations of ascorbic acid, 25-hydroxyvitamin D (25(OH)D), erythrocyte membrane fatty acids following birth until IA seroconversion under nested case-control design. We grouped children having an initial autoantibody only against insulin (IAA-first) or glutamic acid decarboxylase (GADA-first) by unsupervised clustering of temporal lipidome, identifying a subgroup of children having early onset of each initial autoantibody, i.e., IAA-first by 12 months and GADA-first by 21 months, consistent with population-wide early seroconversion age. Differential analysis showed that infants having reduced plasma ascorbic acid and cholesterol experienced IAA-first earlier, while early onset of GADA-first was preceded by reduced sphingomyelins at infancy. Plasma 25(OH)D prior to either autoantibody was lower in T1D progressors compared to non-progressors, with simultaneous lower diglycerides, lysophosphatidylcholines, triglycerides, alanine before GADA-first. Plasma ascorbic acid and 25(OH)D at infancy were lower in HLA-DR3/DR4 children among IA cases but not in matched controls, implying gene expression dysregulation of circulating vitamins as latent signals for IA or T1D progression.

Subject headings and genre

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  • Liu, XiangUniversity of South Florida; Department of Sociology (author)
  • Yang, JiminUniversity of South Florida; Department of Sociology (author)
  • Erlund, IrisFinnish National Institute for Health and Welfare (author)
  • Lernmark, ÅkeLund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups(Swepub:lu)endo-ale (author)
  • Hagopian, WilliamPacific Northwest Research Institute (author)
  • Rewers, MarianUniversity of Colorado-Denver (author)
  • She, Jin-XiongMedical College of Georgia (author)
  • Toppari, JormaTurku University Hospital (author)
  • Ziegler, Anette-GJalisco Institute of Diabetes and Obesity Research SC (author)
  • Akolkar, BeenaNational Institutes Of Health Clinical Center (author)
  • Krischer, Jeffrey PUniversity of South Florida; Department of Sociology (author)
  • Shriners Hospitals for ChildrenUniversity of South Florida (creator_code:org_t)
  • TEDDY Study Group

Related titles

  • In:Diabetes: American Diabetes Association70:1, s. 282-2921939-327X0012-1797

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