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GWAS of bone size y...
GWAS of bone size yields twelve loci that also affect height, BMD, osteoarthritis or fractures
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- Styrkarsdottir, Unnur (author)
- deCODE Genetics
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- Stefansson, Olafur A. (author)
- deCODE Genetics
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- Gunnarsdottir, Kristbjorg (author)
- deCODE Genetics
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- Thorleifsson, Gudmar (author)
- deCODE Genetics
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- Lund, Sigrun H. (author)
- deCODE Genetics,University of Iceland
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- Stefansdottir, Lilja (author)
- deCODE Genetics
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- Juliusson, Kristinn (author)
- deCODE Genetics
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- Agustsdottir, Arna B. (author)
- deCODE Genetics
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- Zink, Florian (author)
- deCODE Genetics
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- Halldorsson, Gisli H. (author)
- deCODE Genetics
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- Ivarsdottir, Erna V. (author)
- deCODE Genetics
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- Benonisdottir, Stefania (author)
- deCODE Genetics
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- Jonsson, Hakon (author)
- deCODE Genetics
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- Gylfason, Arnaldur (author)
- deCODE Genetics
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- Norland, Kristjan (author)
- deCODE Genetics
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- Trajanoska, Katerina (author)
- Erasmus University Medical Center
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- Boer, Cindy G. (author)
- Erasmus University Medical Center
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- Southam, Lorraine (author)
- Wellcome Trust Sanger Institute,Wellcome Trust Centre for Human Genetics
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- Leung, Jason C.S. (author)
- Chinese University of Hong Kong
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- Tang, Nelson L.S. (author)
- Chinese University of Hong Kong
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- Kwok, Timothy C.Y. (author)
- Chinese University of Hong Kong,Prince of Wales Hospital Hong Kong
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- Lee, Jenny S.W. (author)
- Alice Ho Miu Ling Nethersole Hospital,Chinese University of Hong Kong
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- Ho, Suzanne C. (author)
- Chinese University of Hong Kong
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- Byrjalsen, Inger (author)
- Nordic Bioscience AS
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- Center, Jacqueline R. (author)
- University of New South Wales,University of Notre Dame Australia,Garvan Institute of Medical Research
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- Lee, Seung Hun (author)
- University of Ulsan
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- Koh, Jung Min (author)
- University of Ulsan
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- Lohmander, L. Stefan (author)
- Lund University,Lunds universitet,Lund OsteoArthritis Division - Nedbrytning av ledbrosk: en biologisk process som leder till artros,Forskargrupper vid Lunds universitet,Lund OsteoArthritis Division - Molecular marker research group,Lund University Research Groups
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- Ho-Pham, Lan T. (author)
- Ton Duc Thang University
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- Nguyen, Tuan V. (author)
- University of Technology Sydney,Garvan Institute of Medical Research,University of New South Wales
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- Eisman, John A. (author)
- Garvan Institute of Medical Research,University of Notre Dame Australia,University of New South Wales
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- Woo, Jean (author)
- Chinese University of Hong Kong
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- Leung, Ping C. (author)
- Chinese University of Hong Kong
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- Loughlin, John (author)
- University of Newcastle upon Tyne
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- Zeggini, Eleftheria (author)
- Helmholtz Zentrum München,Wellcome Trust Sanger Institute
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- Christiansen, Claus (author)
- Nordic Bioscience AS
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- Rivadeneira, Fernando (author)
- Erasmus University Medical Center
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- van Meurs, Joyce (author)
- Erasmus University Medical Center
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- Uitterlinden, Andre G. (author)
- Erasmus University Medical Center
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- Mogensen, Brynjolfur (author)
- National University Hospital of Iceland,University of Iceland
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- Jonsson, Helgi (author)
- University of Iceland,National University Hospital of Iceland
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- Ingvarsson, Thorvaldur (author)
- University of Iceland,Akureyri Central Hospital,University of Akureyri
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- Sigurdsson, Gunnar (author)
- National University Hospital of Iceland,University of Iceland
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- Benediktsson, Rafn (author)
- University of Iceland,National University Hospital of Iceland
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- Sulem, Patrick (author)
- deCODE Genetics
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- Jonsdottir, Ingileif (author)
- deCODE Genetics,University of Iceland,National University Hospital of Iceland
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- Masson, Gisli (author)
- deCODE Genetics
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- Holm, Hilma (author)
- deCODE Genetics
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- Norddahl, Gudmundur L. (author)
- deCODE Genetics
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- Thorsteinsdottir, Unnur (author)
- deCODE Genetics,University of Iceland
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- Gudbjartsson, Daniel F. (author)
- deCODE Genetics,University of Iceland
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- Stefansson, Kari (author)
- University of Iceland,deCODE Genetics
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(creator_code:org_t)
- 2019-05-03
- 2019
- English.
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In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 10:1
- Related links:
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http://dx.doi.org/10... (free)
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https://www.nature.c...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Subject headings
Close
- Bone area is one measure of bone size that is easily derived from dual-energy X-ray absorptiometry (DXA) scans. In a GWA study of DXA bone area of the hip and lumbar spine (N ≥ 28,954), we find thirteen independent association signals at twelve loci that replicate in samples of European and East Asian descent (N = 13,608 – 21,277). Eight DXA area loci associate with osteoarthritis, including rs143384 in GDF5 and a missense variant in COL11A1 (rs3753841). The strongest DXA area association is with rs11614913[T] in the microRNA MIR196A2 gene that associates with lumbar spine area (P = 2.3 × 10 −42 , β = −0.090) and confers risk of hip fracture (P = 1.0 × 10 −8 , OR = 1.11). We demonstrate that the risk allele is less efficient in repressing miR-196a-5p target genes. We also show that the DXA area measure contributes to the risk of hip fracture independent of bone density.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Ortopedi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Orthopaedics (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Styrkarsdottir, ...
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Stefansson, Olaf ...
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Gunnarsdottir, K ...
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Thorleifsson, Gu ...
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Lund, Sigrun H.
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Stefansdottir, L ...
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show more...
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Juliusson, Krist ...
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Agustsdottir, Ar ...
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Zink, Florian
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Halldorsson, Gis ...
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Ivarsdottir, Ern ...
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Benonisdottir, S ...
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Jonsson, Hakon
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Gylfason, Arnald ...
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Norland, Kristja ...
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Trajanoska, Kate ...
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Boer, Cindy G.
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Southam, Lorrain ...
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Leung, Jason C.S ...
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Tang, Nelson L.S ...
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Kwok, Timothy C. ...
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Lee, Jenny S.W.
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Ho, Suzanne C.
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Byrjalsen, Inger
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Center, Jacqueli ...
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Lee, Seung Hun
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Koh, Jung Min
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Lohmander, L. St ...
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Ho-Pham, Lan T.
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Nguyen, Tuan V.
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Eisman, John A.
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Woo, Jean
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Leung, Ping C.
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Loughlin, John
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Zeggini, Elefthe ...
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Christiansen, Cl ...
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Rivadeneira, Fer ...
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van Meurs, Joyce
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Uitterlinden, An ...
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Mogensen, Brynjo ...
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Jonsson, Helgi
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Ingvarsson, Thor ...
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Sigurdsson, Gunn ...
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Benediktsson, Ra ...
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Sulem, Patrick
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Jonsdottir, Ingi ...
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Masson, Gisli
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Holm, Hilma
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Norddahl, Gudmun ...
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Thorsteinsdottir ...
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Gudbjartsson, Da ...
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Stefansson, Kari
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Orthopaedics
- Articles in the publication
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Nature Communica ...
- By the university
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Lund University