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The Life History of...
The Life History of 21 Breast Cancers
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Nik-Zainal, Serena (author)
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Van Loo, Peter (author)
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Wedge, David C. (author)
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Alexandrov, Ludmil B. (author)
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Greenman, Christopher D. (author)
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Lau, King Wai (author)
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Raine, Keiran (author)
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Jones, David (author)
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Marshall, John (author)
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Ramakrishna, Manasa (author)
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Shlien, Adam (author)
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Cooke, Susanna L. (author)
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Hinton, Jonathan (author)
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Menzies, Andrew (author)
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Stebbings, Lucy A. (author)
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Leroy, Catherine (author)
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Jia, Mingming (author)
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Rance, Richard (author)
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Mudie, Laura J. (author)
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Gamble, Stephen J. (author)
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Stephens, Philip J. (author)
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McLaren, Stuart (author)
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Tarpey, Patrick S. (author)
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Papaemmanuil, Elli (author)
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Davies, Helen R. (author)
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Varela, Ignacio (author)
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McBride, David J. (author)
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Bignell, Graham R. (author)
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Leung, Kenric (author)
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Butler, Adam P. (author)
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Teague, Jon W. (author)
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Martin, Sancha (author)
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Joensson, Goran (author)
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Mariani, Odette (author)
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Boyault, Sandrine (author)
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Miron, Penelope (author)
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Fatima, Aquila (author)
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Langerod, Anita (author)
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Aparicio, Samuel A. J. R. (author)
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Tutt, Andrew (author)
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Sieuwerts, Anieta M. (author)
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- Borg, Åke (author)
- Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
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Thomas, Gilles (author)
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Salomon, Anne Vincent (author)
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Richardson, Andrea L. (author)
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Borresen-Dale, Anne-Lise (author)
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Futreal, P. Andrew (author)
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Stratton, Michael R. (author)
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Campbell, Peter J. (author)
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(creator_code:org_t)
- Elsevier BV, 2012
- 2012
- English.
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In: Cell. - : Elsevier BV. - 1097-4172 .- 0092-8674. ; 149:5
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http://dx.doi.org/10...
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http://www.cell.com/...
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Abstract
Subject headings
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- Cancer evolves dynamically as clonal expansions supersede one another driven by shifting selective pressures, mutational processes, and disrupted cancer genes. These processes mark the genome, such that a cancer's life history is encrypted in the somatic mutations present. We developed algorithms to decipher this narrative and applied them to 21 breast cancers. Mutational processes evolve across a cancer's lifespan, with many emerging late but contributing extensive genetic variation. Subclonal diversification is prominent, and most mutations are found in just a fraction of tumor cells. Every tumor has a dominant subclonal lineage, representing more than 50% of tumor cells. Minimal expansion of these subclones occurs until many hundreds to thousands of mutations have accumulated, implying the existence of long-lived, quiescent cell lineages capable of substantial proliferation upon acquisition of enabling genomic changes. Expansion of the dominant subclone to an appreciable mass may therefore represent the final rate-limiting step in a breast cancer's development, triggering diagnosis.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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Cell
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To the university's database
- By the author/editor
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Nik-Zainal, Sere ...
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Van Loo, Peter
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Wedge, David C.
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Alexandrov, Ludm ...
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Greenman, Christ ...
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Lau, King Wai
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show more...
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Raine, Keiran
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Jones, David
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Marshall, John
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Ramakrishna, Man ...
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Shlien, Adam
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Cooke, Susanna L ...
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Hinton, Jonathan
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Menzies, Andrew
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Stebbings, Lucy ...
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Leroy, Catherine
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Jia, Mingming
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Rance, Richard
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Mudie, Laura J.
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Gamble, Stephen ...
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Stephens, Philip ...
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McLaren, Stuart
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Tarpey, Patrick ...
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Papaemmanuil, El ...
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Davies, Helen R.
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Varela, Ignacio
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McBride, David J ...
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Bignell, Graham ...
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Leung, Kenric
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Butler, Adam P.
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Teague, Jon W.
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Martin, Sancha
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Joensson, Goran
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Mariani, Odette
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Boyault, Sandrin ...
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Miron, Penelope
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Fatima, Aquila
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Langerod, Anita
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Aparicio, Samuel ...
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Tutt, Andrew
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Sieuwerts, Aniet ...
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Borg, Åke
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Thomas, Gilles
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Salomon, Anne Vi ...
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Richardson, Andr ...
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Borresen-Dale, A ...
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Futreal, P. Andr ...
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Stratton, Michae ...
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Campbell, Peter ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Cell
- By the university
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Lund University